Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil

ELBeltagy, Maha; Mustafa, Sarah; Umka, Jariya; Lyons, Laura; Salman, Ahmed; Chur-yoe, Gloria Tu; Bhalla, Nikita; Bennett, Gerald; Wigmore, Peter

doi:10.1016/j.bbr.2009.11.017

Cited by 110 publications

(89 citation statements)

References 66 publications

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“…Importantly, in mice, treatment with clinically equivalent doses of 5FU are sufficient to cause reductions in myelin integrity that are associated with functional changes in impulse conduction within the auditory system (Han et al 2008). Furthermore, treatment with 5FU alone has been shown to induce impairments in measures of cognition in laboratory rodents; object location recognition (Mustafa et al 2008), conditioned emotional response learning (ElBeltagy et al 2010) and retrieval of an instrumental nose poke response (Foley et al 2008) are impaired after 5FU treatment. OX induces a profile of peripheral neurotoxicity in both rodents and humans indicating that potentially both peripheral and central nervous systems may be affected by systemic treatment (Norcini et al 2009;Park et al 2008).…”

Section: Introductionmentioning

confidence: 97%

Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity

et al. 2011

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Section: Introductionmentioning

confidence: 97%

Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity

et al. 2011

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“…Although the mechanisms of this effect are unknown, there is evidence that this may be due to its effect of increasing hippocampal neurogenesis (ElBeltagy et al, 2010;Lyons et al, 2011a). Fluoxetine is also a powerful anti-neuroinflammatory agent (Chung et al, 2011) and this action may affect neural function directly, as neuroinflammation is a prominent process in the initiation and maintenance of hippocampal sclerosis (Vezzani et al, 2008), the most common cause of mesial temporal lobe epilepsy.…”

Section: Effects Of Fluoxetinementioning

confidence: 99%

“…The antidepressant fluoxetine is a powerful stimulant of hippocampal neurogenesis (Malberg et al, 2000) and improves memory deficits in patients with mild cognitive impairment (Mowla et al, 2007), and after traumatic brain injury (Horsfield et al, 2002). In animal models, fluoxetine-induced neurogenesis is associated with improved allocentric spatial learning and memory after ischaemic injury (Li et al, 2009), and restoration of deficits in spatial working memory after anti-mitotic treatment (ElBeltagy et al, 2010;Lyons et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

Barkas

Redhead

Taylor

et al. 2012

Brain

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Learning and memory dysfunction is the most common neuropsychological effect of mesial temporal lobe epilepsy, and because the underlying neurobiology is poorly understood, there are no pharmacological strategies to help restore memory function in these patients. We have demonstrated impairments in the acquisition of an allocentric spatial task, in patients with unilateral hippocampal sclerosis. We also show that patients have accelerated forgetting of the learned spatial task and that this is associated with damage to the non-dominant hippocampal formation. We go on to show a very similar pattern of chronic allocentric learning and accelerated forgetting in a status epilepticus model of mesial temporal lobe epilepsy in rats, which is associated with reduced and abnormal hippocampal neurogenesis. Finally, we show that reversal of the neurogenic deficit using fluoxetine is associated with reversal of the learning deficit but not the accelerated forgetting, pointing to a possible dissociation in the underlying mechanisms, as well as a potential therapeutic strategy for improving hippocampal-dependant learning in patients with mesial temporal lobe epilepsy.

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“…Modares, Hero, Rosli Salleh2011 [10] For receiving the information from an insecure environment we generally approach to wireless sensor networks (WSN). In WSN security protocols they think that all the attackers can get complete access by the way of direct physical access.…”

Section: Pelechrinis Konstantinos Mariosiliofotou 2011asmentioning

confidence: 99%

Ddos Attack on Wireless Sensor Network: A Review

Pandey¹

2017

ijarcs

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Controlling the denial of service attacks in the wireless sensor networks are becoming more difficult, and now it seems like a Halloween in network where the ghostly creatures are moving fearless. On the other way, this also obstruct the understanding of DDoS phenomenon. The diverse variety of such attacks makes a view that the world of these attacks is very vast and its difficult to explore and resist that. For preventing these attacks, it is necessary to understand the problems and faults in our networks and see the current solution space.

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Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil

Cited by 110 publications

References 66 publications

Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity

Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

Ddos Attack on Wireless Sensor Network: A Review

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