Fluoxetine-Induced Memory Impairment in an Adolescent

Bangs, Mark E.; Petti, Theodore A.; Janus, Mark-David

doi:10.1097/00004583-199411000-00012

Cited by 30 publications

(16 citation statements)

References 18 publications

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“…For instance, Carlini et al [49] found that adult male mice chronically treated with the selective 5-HT reuptake inhibitor fluoxetine presented an increase in 5-HT levels, but showed a poor memory retention in the object recognition test. Deleterious actions in memory, after chronic treatment with fluoxetine, have also been reported at clinical levels [50], specifically on visual memory [51]. …”

Section: Discussionmentioning

confidence: 99%

Helminth Infection Alters Mood and Short-Term Memory as well as Levels of Neurotransmitters and Cytokines in the Mouse Hippocampus

Morales‐Montor

Picazo²,

Besedovsky

et al. 2014

Neuroimmunomodulation

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Helminthic infections are important causes of morbidity and mortality in many developing countries, where children bear the greatest health burden. The ability of parasites to cause behavioral changes in the host has been observed in a variety of host-parasite systems, including the Taenia crassiceps-mouse model. In murine cysticercosis, mice exhibit a disruption in the sexual, aggressive and avoidance predator behaviors. Objective: The present study was conducted to characterize short-term memory and depression-like behavior, as well as levels of neurotransmitters and cytokines in the hippocampus of cysticercotic male and female mice. Methods: Cytokines were detected by RT-PCR and neurotransmitters were quantified by HPLC. Results: Chronic cysticercosis infection induced a decrease in short-term memory in both male and female mice, having a more pronounced effect in females. Infected females showed a significant increase in forced swimming tests with a decrease in immobility. In contrast, male mice showed an increment in total activity and ambulation tests. Serotonin levels decreased by 30% in the hippocampus of infected females whereas noradrenaline levels significantly increased in infected males. The hippocampal expression of IL-4 increased in infected female mice, but decreased in infected male mice. Conclusion: Our study suggests that intraperitoneal chronic infection with cysticerci in mice leads to persistent deficits in tasks dependent on the animal's hippocampal function. Our findings are a first approach to elucidating the role of the neuroimmune network in controlling short-term memory and mood in T. crassiceps-infected mice.

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Section: Discussionmentioning

confidence: 99%

Helminth Infection Alters Mood and Short-Term Memory as well as Levels of Neurotransmitters and Cytokines in the Mouse Hippocampus

Morales‐Montor

Picazo²,

Besedovsky

et al. 2014

Neuroimmunomodulation

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“…Especially since adverse events or possible medication side effects (increased irritability, fatigue, and impaired school performance) have been reported in children treated with fluoxetine [12,27,28]. Based on the results of the latter measures, we discontinued the initial 10 mg fluoxetine dose after 2 weeks for one participant because of complaints.…”

Section: Discussionmentioning

confidence: 99%

Fluoxetine Monotherapy in Attention-Deficit/Hyperactivity Disorder and Comorbid Non-Bipolar Mood Disorders in Children and Adolescents

Quintana

Butterbaugh

Purnell

et al. 2006

Child Psychiatry Hum Dev

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Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for developing comorbid non-bipolar mood disorders. Fluoxetine monotherapy is an established treatment for pediatric mood disorders; however its efficacy in ADHD and comorbid mood disorder is unknown. Therefore, we evaluated 30 children who met DSM-IV criteria for ADHD and comorbid non-bipolar mood disorders in a prospective, 6-12-week open-label, study of fluoxetine monotherapy. Fluoxetine was associated with significant decreases in the severity of depressive symptoms, and also, associated with significant decreases on subscales of inattention/overactivity and aggression/defiant symptoms-47% of participants were much or very much improved without observed adverse effects.

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“…On the one hand, chronic administration of low doses of fluoxetine (0.7 mg/kg once daily for 28 days) in adult rats did not affect learning and short-term memory, but rather it impaired long-term memory [88]; on the other hand, in adolescent rats subchronic fluoxetine treatment induced cognitive deficits evident in the Morris water maze [89]. These contradictory results could be explained due to different ages tested, and indeed, cognitive deficits have been detected in clinical trials on adolescent patients treated with fluoxetine [90].…”

Section: Effect On Cognitionmentioning

confidence: 96%