Fluoxetine Potentiation of Omega-3 Fatty Acid Antidepressant Effect: Evaluating Pharmacokinetic and Brain Fatty Acid-Related Aspects in Rodents

Laino, Carlos Horacio; García, Pedro González; Podestá, María Fernanda; Höcht, Christián; Slobodianik, Nora; Reinés, Analı́a

doi:10.1002/jps.24123

Cited by 18 publications

(12 citation statements)

References 68 publications

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“…To the best of our knowledge, our work is the first study to appraise the causality between DPA and lung cancer risk. Based on previous research results, DPA has been linked to better health and lower total mortality . The possible mechanisms of the protective effect of DPA include inhibiting platelet aggregation, stimulating endothelial cell migration, reducing age‐related oxidative damage, and inhibiting inflammation .…”

Section: Discussionmentioning

confidence: 99%

Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study

et al. 2019

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Background Observational studies have shown that excessive dietary fat may be associated with lung carcinogenesis. However, findings from previous studies are inconsistent and it remains unclear whether docosapentaenoic acid (DPA), a kind of polyunsaturated fatty acid, is linked to the risk of lung cancer. The aim of this study is to investigate the causal effect of DPA on lung cancer with Mendelian randomization (MR) method. Methods With a two‐sample MR approach, we analyzed the summary data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE, 8866 individuals of European ancestry) Consortium and International Lung Cancer Consortium (ILCCO, 11 348 lung cancer cases and 15 861 controls; European ancestry) to assess the possible causal relationship of DPA on the risk of lung cancer. Results Our results indicated that genetically predicted higher DPA level has a positive association with lung cancer, where 1% higher DPA was associated with a 2.01‐fold risk of lung cancer (odds ratio [OR]: 2.01, 95% CI = 1.34‐3.01; P = 7.40 × 10−4). Additionally, lung cancer was not a causal factor for DPA. The results of MR‐Egger regression analysis showed that there was no evidence for the presence of directional horizontal pleiotropy. Conclusions Genetically elevated DPA is positively associated with risk of lung cancer, and more work is needed to investigate the potential mechanisms.

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Section: Discussionmentioning

confidence: 99%

Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study

et al. 2019

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“…Additionally, low blood levels of DPA during pregnancy were linked to a higher prevalence of postpartum depression . In rodent studies, supplementation with purified DPA increased the levels of DPA and DHA in the brain, and reduced depression symptoms as measured by behavioural tests . Another study in mice suggested that DPA might help to improve outcomes of spinal cord injury .…”

Section: Biological Functions Of Dpamentioning

confidence: 99%

Dietary sources, current intakes, and nutritional role of omega‐3 docosapentaenoic acid

2015

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Fish oils and long-chain omega-3 fatty acids are well recognized for their critical role in human diets. Docosapentaenoic acid (DPA, 22 : 5n-3) has always been a part of healthy nutrition, since infants obtain almost as much DPA as DHA from human milk. Fish oil supplements and ingredients, oily fish, and grass-fed beef can serve as the primary DPA sources for the general population. Although the DPA levels in fish oils are substantially lower than those of EPA and DHA, concentrated DPA products are now becoming commercially available, and DPA-based drugs are under development.Epidemiological studies show that similar to eicosapentaenoic (EPA, 20 : 5n-3) and docosahexaenoic (DHA, 22 : 6n-3) acids, DPA is linked to various improvements in human health, perhaps owing to its structural similarity to the other two molecules. Studies in mammals, platelets, and cell cultures have demonstrated that DPA reduces platelet aggregation, and improves lipid metabolism, endothelial cell migration, and resolution of chronic inflammation. Further, other in vivo and in vitro studies have shown that DPA can improve neural health. A human supplementation trial with 99.8% pure DPA suggested that it serves as a storage depot for EPA and DHA in the human body. Future randomized controlled human trials with purified DPA will help clarify its effects on human health. They may confirm the available evidence pointing to its nutritional and biological functions, unique or overlapping with those of EPA and DHA.

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“…In rats receiving 250 mg/d DPA, plasma EPA, and liver EPA and DHA concentrations were significantly increased compared with olive oil‐supplemented controls . Similarly, DPA intake significantly increased DPA and DHA levels in the hippocampus of supplemented rats, indicating that DPA may be directly converted to DHA in the brain .…”

Section: Dpa: a Reservoir For Epa And Dhamentioning

confidence: 91%

“…For example, a number of reports have found a correlation with lower levels of DPA in the blood and brain function in people with mental health disorders [3][4][5][6]. Similarly, in mammalian models, DPA supplementation has been reported to have an antidepressant-like effect [7] and improves brain function [8]. The neuroprotective effect of endogenous DPA against spinal cord injury in mammals has also been reported [9].…”

Section: Introductionmentioning

confidence: 98%

The role of Omega‐3 docosapentaenoic acid in pregnancy and early development

Li¹,

Yin²,

Bibus

et al. 2016

Euro J Lipid Sci & Tech

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Docosapentaenoic acid (DPA, 22:5n‐3) is normally present in small quantities in marine products. Metabolically, it can directly convert to docosahexaenoic acid (DHA, 22:6n‐3) and retro‐convert into eicosapentaenoic acid (EPA, 20:5n‐3), suggesting that it may serve as a reservoir for these fatty acids in human body. Among other biological functions, DPA serves a precursor to anti‐inflammatory and pro‐resolving mediators. Further, either consumption of DPA or its blood levels are associated with positive human health outcomes, and in vitro and in vivo models have confirmed and highlighted DPA's biological role in mammals. Because the role of DHA in prenatal and postnatal development is well known, most infant formulas are now supplemented with DHA. Although human breast milk contains significant levels of DHA, importantly, its levels of DPA are comparable. Despite this, the importance of DPA in infant and maternal health is less recognized. Our review highlights that DPA intake (often along with EPA and DHA) by lactating mothers is linked to better neural development and bone health of children. Additionally, blood levels of DPA in mothers are associated with fewer allergic diseases such as asthma, rhinitis, and eczema in children and mothers. The daily dietary intake of DPA in breast‐fed infants in various populations ranges from 5.1 to 44.6 mg/kg body weight, which would translate to 357–3122 mg/d for a 70‐kg adult. The reported health effects of DPA suggest it may be beneficial to increase the intake of DPA during prenatal and early postnatal life stages. Practical applications: This paper reviewed all research articles related with DPA health benefits in human development and summarized the potential function of DPA in human during pregnancy and early development. In vitro and in vivo studies both indicated that DPA has important biological role in mammals. The fact that DPA is high in human breast milk shows the potential biological function of DPA in infant development. The authors recommend infant formula manufacturers to consider adding DPA to infant food and encourage researchers to conduct human clinical studies to further prove the biological function of DPA in human development. LC Omega‐3 fatty acids play a critical role in human nutrition and health. DPA's role as a reservoir for DHA and EPA highlights the importance in human physiology. This study demonstrates the association between blood DPA levels and both infant and maternal health, and suggests the recommendation for DPA consumption during prenatal and early postnatal life stages.

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Fluoxetine Potentiation of Omega-3 Fatty Acid Antidepressant Effect: Evaluating Pharmacokinetic and Brain Fatty Acid-Related Aspects in Rodents

Cited by 18 publications

References 68 publications

Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study

Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study

Dietary sources, current intakes, and nutritional role of omega‐3 docosapentaenoic acid

The role of Omega‐3 docosapentaenoic acid in pregnancy and early development

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