1997
DOI: 10.1016/s0149-2918(97)80066-5
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Fluoxetine tenth anniversary update: the progress continues

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Cited by 120 publications
(82 citation statements)
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References 300 publications
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“…In our experiment, treatment with fluoxetine, a serotonin (5-HT) selective reuptake inhibitor (SSRI) with well-known clinical efficacy (Stokes and Holtz, 1997) prevented the chronic stressinduced effect. The serotonergic innervation of the hippocampus originates from the dorsal and median raphe nuclei, but only 21% of serotonin-containing varicosities make synaptic contacts, mostly with dendrites and somata of GABAergic interneurons, and it has been suggested that those varicosities without synaptic contact release 5-HT at nonsynaptic sites for long distance diffusion (Vizi and Kiss, 1998).…”
Section: Antidepressant Treatment Can Counteract the Effect Of Stressmentioning
confidence: 81%
“…In our experiment, treatment with fluoxetine, a serotonin (5-HT) selective reuptake inhibitor (SSRI) with well-known clinical efficacy (Stokes and Holtz, 1997) prevented the chronic stressinduced effect. The serotonergic innervation of the hippocampus originates from the dorsal and median raphe nuclei, but only 21% of serotonin-containing varicosities make synaptic contacts, mostly with dendrites and somata of GABAergic interneurons, and it has been suggested that those varicosities without synaptic contact release 5-HT at nonsynaptic sites for long distance diffusion (Vizi and Kiss, 1998).…”
Section: Antidepressant Treatment Can Counteract the Effect Of Stressmentioning
confidence: 81%
“…We focused on astroglia because of the growing number of data indicating that the role of astrocytes in function of the central nervous system so far has been considerably underestimated (Fields and Stevens-Graham, 2002). Additionally, we examined whether treatment with the antidepressant fluoxetine, a selective serotonin reuptake inhibitor (SSRI) with well-known clinical efficacy (Stokes and Holtz, 1997), offers protection from possible stressinduced morphological alterations. This approach was based on recent clinical and preclinical findings, which suggest that depressive disorders may be associated with an impairment of structural plasticity and cellular resilience, and that antidepressant medications may correct this dysfunction (Manji and Duman, 2001;Manji et al, 2000Manji et al, , 2003.…”
Section: Introductionmentioning
confidence: 99%
“…The very slow elimination of fluoxetine and norfluoxetine differentiates it from other SSRIs (28). Compared with other antidepressants, it is safer in terms of overdose and causes fewer and less severe side effects, which has enhanced patient compliance (56). Fluoxetine has been proposed to have an anti-inflammatory effect.…”
mentioning
confidence: 99%