Fluoxetine treatment alters leukocyte trafficking in the intrathecal compartment of the young primate

Coe, Christopher L.; Hou, Fang-Yao; Clarke, A. S.

doi:10.1016/0006-3223(95)00428-9

Cited by 7 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concentration of freefloating cells in CSF must be a function of their rate of entry into, duration of residence in, and rate of exit from CSF. [39][40][41][42] If CSF pleocytosis is an indicator of increased cellular trafficking, then CSF HIV dynamics should parallel plasma dynamics in patients with pleocytosis, as we observed. 38 It seems reasonable, therefore, to assert that elevated chemokine levels and pleocytosis reflect increased cellular trafficking; this reasoning has guided numerous recently published investigations.…”

Section: Discussionsupporting

confidence: 57%

Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources

Ellis

Gamst²,

Capparelli³

et al. 2000

Neurology

191

130

View full text Add to dashboard Cite

CSF and plasma HIV dynamics became increasingly independent in advanced HIV disease, and the compartmental discrepancy was largest in HAD. Our findings suggest that viral replication in CNS tissues may constitute a major, independent source of CSF HIV RNA. In patients with HAD, brain parenchyma itself may be the principal CNS tissue source, and CNS-targeted treatment strategies may be required to eradicate this infection.

show abstract

Section: Discussionsupporting

confidence: 57%

Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources

Ellis

Gamst²,

Capparelli³

et al. 2000

Neurology

191

130

View full text Add to dashboard Cite

show abstract

“…Long-term treatment studies in nonhuman primates with pathological examination of multiple tissue types can be performed to address the question of late effects. One primate study showed that a three-month fluoxetine treatment in infancy altered leukocyte trafficking in the intrathecal compartment in the adolescent monkey but did not alter the cell profile in blood [11], however to our knowledge, no study in nonhuman primates or humans is available in the scientific literature demonstrating pathological changes in bone marrow with long-term administration of either drug.…”

Section: Discussionmentioning

confidence: 95%

Long-term sequestration of fluorinated compounds in tissues after fluvoxamine or fluoxetine treatment: a fluorine magnetic resonance spectroscopy study in vivo

Bolo

Hodé²,

Mâcher³

2004

MAGMA Magnetic Resonance Materials in Physics, Biology and Medi

View full text Add to dashboard Cite

Fluorine magnetic resonance spectroscopy (19F MRS), spectroscopic imaging (MRSI) and proton anatomical magnetic resonance imaging (1H MRI) were performed on brains and lower extremities of six subjects in vivo concurrently with HPLC of serum to investigate tissue and plasma drug localization and withdrawal kinetics in humans treated with fluvoxamine or fluoxetine. 19F MRS signal was unexpectedly detected in the lower extremities months after complete disappearance of signal from plasma and brain. MRSI suggested that the lower extremity fluvoxamine signal originated mainly from bone marrow. Results suggest long-term sequestration of these drugs or their metabolites mainly in bone marrow and possibly in surrounding tissue and demonstrate the usefulness of MRS to reveal drug-trapping compartments in the body.

show abstract

“…Hence, serotonin itself and SSRIs, such as paroxetine or fluoxetine, are able to stimulate NK‐cell activity in depressed patients exhibiting low activity at baseline. Furthermore, the administration of fluoxetine was associated with an alteration of leukocyte trafficking in primates;31 and the 5‐HT 1A receptor agonist ipsapirone, which is given to depressed patients, led to a significant reduction of peripheral CD4 cells 32…”

Section: Studies In Noncontrolled Settings: Basal Cell‐mediated Immunmentioning

confidence: 99%

Cell‐Mediated Immune Response in MDMA Users After Repeated Dose Administration

Pacifici

Zuccaro

Farré

et al. 2002

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Acute administration of 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) produces time‐dependent immune dysfunction in humans. Recreational use of MDMA generally includes repeated drug consumption, often in association with other drugs, such as alcohol and cannabis. In the laboratory setting, repeated MDMA administration to healthy MDMA consumers produced a time‐dependent immune dysfunction similar to that observed with the ingestion of a single dose, and the first of the two administrations paralleled the time‐course of MDMA‐induced cortisol stimulation kinetics and MDMA plasma concentrations. A significant decrease in CD4 T‐helper cells with simultaneous increase in natural killer (NK) cell and a decrease in functional responsiveness of lymphocytes to mitogenic stimulation was observed. Response to the second dose was either long‐lasting compared with the first dose or disproportionate and did not show any parallelism with cortisol and MDMA plasma concentrations. This circumstance extended the critical period during which immunocompetence is highly impaired as a result of MDMA use. Accumulation of MDMA in the body of a poor metabolizer induced higher immunomodulatory effects with statistically significant differences in NK cell function compared with extensive metabolizers. When basal values of lymphocyte subsets were examined in a population of recreational MDMA users participating in different clinical trials, alterations in several immunological parameters were observed. The absolute number of lymphocytes, in particular T lymphocytes and CD4 T‐helper cell subsets, showed a trend toward reduced values, although cell counts were within normal limits. By contrast, NK cells in MDMA consumers were reduced to one‐third of those from healthy persons. A statistically significant decrease in affected immune parameters was recorded during a 2‐year observation period in a subgroup of recreational MDMA users. These permanent alterations in immunologic homeostasis may result in impairment of general health and subsequent increased susceptibility to infection and immune‐related disorders.

show abstract

Fluoxetine treatment alters leukocyte trafficking in the intrathecal compartment of the young primate

Cited by 7 publications

References 26 publications

Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources

Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources

Long-term sequestration of fluorinated compounds in tissues after fluvoxamine or fluoxetine treatment: a fluorine magnetic resonance spectroscopy study in vivo

Cell‐Mediated Immune Response in MDMA Users After Repeated Dose Administration

Contact Info

Product

Resources

About