2014
DOI: 10.1186/1756-3305-7-275
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Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment

Abstract: BackgroundFluralaner, a novel isoxazoline, has both acaricidal and insecticidal activity through potent blockage of GABA- and L-glutamate-gated chloride channels. This study investigated the in vitro and in vivo effects of fluralaner exposure on flea (Ctenocephalides felis) reproduction.MethodsBlood spiked with sub-insecticidal fluralaner concentrations (between 0.09 and 50.0 ng/mL) was fed to fleas for 10 days using a membrane system. Cessation of reproduction in exposed fleas was assessed using flea survival… Show more

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Cited by 45 publications
(39 citation statements)
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“…There is a wide assortment of approved oral and topical canine F/T medications with various modes of action and in various combinations, including some with insect growth regulator activity and some with canine heartworm (HW) indications. Fluralaner is a recently approved active ingredient in the isoxazoline class available in oral chewable formulation (Fluralaner, Merck Animal Health, Madison, NJ, USA) for dogs and a topical formulation for dogs and cats [4,5]. The fluralaner re-treatment interval is three times longer than the re-treatment interval for other flea/tick products that are dosed every 4 weeks.…”
Section: Introductionmentioning
confidence: 99%
“…There is a wide assortment of approved oral and topical canine F/T medications with various modes of action and in various combinations, including some with insect growth regulator activity and some with canine heartworm (HW) indications. Fluralaner is a recently approved active ingredient in the isoxazoline class available in oral chewable formulation (Fluralaner, Merck Animal Health, Madison, NJ, USA) for dogs and a topical formulation for dogs and cats [4,5]. The fluralaner re-treatment interval is three times longer than the re-treatment interval for other flea/tick products that are dosed every 4 weeks.…”
Section: Introductionmentioning
confidence: 99%
“…The sustained speed of kill of an insecticidal product is essential for the control of environmental contamination by immature flea stages. The ability to prevent egg production has recently been demonstrated in experimental studies with ectoparasiticides containing isoxazolines (afoxolaner, sarolaner or fluralaner) having a sustained speed of kill of less than 24 h for 1–3 months [3, 19, 20]. It has also been demonstrated in the field in studies using flea traps to assess environmental control [7, 8].…”
Section: Discussionmentioning
confidence: 99%
“…Anti-flea products containing insect growth regulators (IGRs) have proven to be effective for the control of infested environments [4, 13, 17]. Without IGRs, it has been demonstrated recently with ectoparasiticides containing afoxolaner, fluralaner or sarolaner, that a sustained high speed of kill can prevent egg production and thus avoid environmental contamination by immature flea stages [3, 7, 8, 19, 20]. …”
Section: Introductionmentioning
confidence: 99%
“…Fluralaner is an isoxaline insecticide and acaricide with high activity, having the dual mechanisms of action of gamma aminobutyric acid and L‐glutamate chloride channel blockade in susceptible invertebrate parasites. It is highly selective for arthropods and has a wide margin of safety in vertebrates . It is approved for use in dogs and cats for flea and tick prevention in the USA, and efficacy has been reported in the treatment of Demodex spp .…”
Section: Introductionmentioning
confidence: 99%