Flurbiprofen in rapid eye movement sleep deprivation induced hyperalgesia

Gürel, Elif Ezgi; Ural, Keremcan; Öztürk, Gülnur; Öztürk, Levent

doi:10.1016/j.physbeh.2014.02.003

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…Developing nociception biomarkers that are unbiased by psychological states remains a current challenge for pain science. The possibilities of combining the sleep deprivation model with more objective measures of nociception and pain are exciting, as they allow to translate results from earlier pharmacological animal studies using sleep deprivation, e.g., (Gürel et al 2014;Skinner et al 2011;Wodarski et al 2015), to humans with potential applications in the identification of analgesic and sedative compounds.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation

et al. 2022

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Sleep deprivation has been shown to increase pain intensity and decrease pain thresholds in healthy subjects. In chronic pain patients, sleep impairment often worsens the perceived pain intensity. This increased pain perception is the result of altered nociceptive processing. We recently developed a method to quantify and monitor altered nociceptive processing by simultaneous tracking of psychophysical detection thresholds and recording of evoked cortical potentials during intra-epidermal electric stimulation. In this study, we assessed the sensitivity of nociceptive detection thresholds and evoked potentials to altered nociceptive processing after sleep deprivation in an exploratory study with 24 healthy male and 24 healthy female subjects. In each subject, we tracked nociceptive detection thresholds and recorded central evoked potentials in response to 180 single- and 180 double-pulse intra-epidermal electric stimuli. Results showed that the detection thresholds for single- and double-pulse stimuli and the average central evoked potential for single-pulse stimuli were significantly decreased after sleep deprivation. When analyzed separated by sex, these effects were only significant in the male population. Multivariate analysis showed that the decrease of central evoked potential was associated with a decrease of task-related evoked activity. Measurement repetition led to a decrease of the detection threshold to double-pulse stimuli in the mixed and the female population, but did not significantly affect any other outcome measures. These results suggest that simultaneous tracking of psychophysical detection thresholds and evoked potentials is a useful method to observe altered nociceptive processing after sleep deprivation, but is also sensitive to sex differences and measurement repetition.

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Section: Discussionmentioning

confidence: 99%

Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation

et al. 2022

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“…A modification of this paradigm was introduced to circumvent isolation and movement restriction by allowing a socially stable group of animals to be sleep-deprived together in a large tank containing multiple small platforms (Coenen and Van Luijtelaar, 1985 ). While 6 h of this paradigm does not change heat and mechanical pain sensitivity and 24 h has limited effects (Onen et al, 2000 ; Wei et al, 2007 ; Wang et al, 2015 ; Tomim et al, 2016 ; Nasehi et al, 2018 ; Sardi et al, 2018b ), two or more consecutive days are systematically associated with an increase in pain responses for mild (44–46 C) (Onen et al, 2000 ; May et al, 2005 ; Damasceno et al, 2009 ; Harvey et al, 2010 ; Skinner et al, 2011 ) and intense (52 C) (Nascimento et al, 2007 ; Damasceno et al, 2009 ; Araujo et al, 2011 ; Gurel et al, 2014 ) heat, pressure (Randall and Selitto) (Ukponmwan et al, 1984 ; Onen et al, 2000 ; Tomim et al, 2016 ) and punctate (von Frey filaments) (Wei et al, 2008 , 2010 ; Damasceno et al, 2009 ) mechanical stimuli, and chemical pain ( Figure 4A ) (Hicks et al, 1979 ; Onen et al, 2000 ; Tomim et al, 2016 ). The development of heat hyperalgesia is stronger in females (Araujo et al, 2011 ).…”

Section: State-specific Sleep Deprivation In Rodentsmentioning

confidence: 99%

Effect of sleep loss on pain—New conceptual and mechanistic avenues

2022

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IntroductionSleep disturbances increase pain sensitivity in clinical and preclinical settings, but the precise mechanisms are unknown. This represents a major public health issue because of the growing sleep deficiency epidemic fueled by modern lifestyle. To understand the neural pathways at the intersection between sleep and pain processes, it is critical to determine the precise nature of the sleep disruptions that increase pain and the specific component of the pain response that is targeted.MethodsWe performed a review of the literature about sleep disturbances and pain sensitivity in humans and rodents by taking into consideration the targeted sleep stage (REMS, non–NREMS, or both), the amount of sleep lost, and the different types of sleep disruptions (partial or total sleep loss, duration, sleep fragmentation or interruptions), and how these differences might affect distinct components of the pain response.ResultsWe find that the effects of sleep disturbances on pain are highly conserved among species. The major driver for pain hypersensitivity appears to be the total amount of sleep lost, while REMS loss by itself does not seem to have a direct effect on pain sensitivity. Sleep loss caused by extended wakefulness preferentially increases pain perception, whereas interrupted and limited sleep strongly dysregulates descending controls such as DNIC, especially in women.DiscussionWe discuss the possible mechanisms involved, including an increase in inflammatory processes, a loss of nociceptive inhibitory pathways, and a defect in the cognitive processing of noxious input.

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“…Wild barley survives severe environmental conditions for a long time developing suitable adaptation system. Due to the natural tolerance of this crop against drought and salinty stresses and fungal diseases [34,35]. and on account of whole identification of its genome sequence [36], the crop has been accepted to be the model plant in stress biology studies.…”

Section: Introductionmentioning

confidence: 99%

Expression Profiling of Salt- And Drought-Stress Responsive Genes in Wild Barley (Hordeum spontaneum L.)

Bakır,

Altınkut Uncuoğlu,

Yüksel Özmen

et al. 2023

Preprint

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Drought and salinity are among the most important abiotic stress factors that limit the productivity in economically important plants. Although genes from wild relatives or unadapted germplasm have often been used for stress tolerance breeding, only few studies have examined wild relatives to understand the genetic and molecular basis of stress tolerance. In this study, we monitored the changes in gene expression profiles of leaf and root tissues of two wild barleys (Hordeum spontaneum L.) accessions from Israel after treatment with salt (NaCl) and drought (PEG) stress. We identified a total of 641 differentially expressed genes across 24 conditions (2 accessions, 2 stress conditions, 2 tissues and 3 time points). Our gene expression analyses revealed large numbers of differentially expressed genes in different accessions by different stress treatments. In addition, the number of genes altered in the leaves of stress-exposed plants of both genotypes was higher than those altered in the roots. Interestingly, there was a relatively little overlap between the leaf and the root stress-responsive gene expression patterns, suggesting that different stress-associated processes might be operating in these tissues during stress adaptation. Overall, our results revealed a number of candidate genes and plant processes associated with stress tolerance in wild barley. Wild barley would be a useful source of new genetic variation for drought and salt stress tolerance. Our results could provide new insights into the mechanisms of drought and salt stress tolerance in wild barley and should be useful for genetic improvement of salt-drought tolerance in cultivated barley.

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Flurbiprofen in rapid eye movement sleep deprivation induced hyperalgesia

Cited by 6 publications

References 16 publications

Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation

Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation

Effect of sleep loss on pain—New conceptual and mechanistic avenues

Expression Profiling of Salt- And Drought-Stress Responsive Genes in Wild Barley (Hordeum spontaneum L.)

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