Flurbiprofen toxicity in 2 dogs

Abstract

Two dogs were presented with melena, vomiting and depression after accidental swallowing of candy form of Strepsils (flurbiprofen), which is one of non-steroidal anti-inflammatory drugs used in human medicine for controlling a sore throat. These dogs had common signs of anemia induced by gastrointestinal ulceration and hemorrhage with azotemia and leukocytosis. The dogs were treated with blood transfusion, fluid therapy, proton-pump inhibitor, antiemetics, mucus protectant and antibiotic. Although most of clinical signs of two dogs were resolved, azotemic problem with evidence of renal injury have remained.

Treatment of flurbiprofen overdose with therapeutic plasma exchange in a dog

“…In veterinary medicine, except for research reports indicating that oral administration of flurbiprofen inhibits bone resorption for chronic destructive periodontal disease, pharmaco-toxicological data are sparse. 5,6 Despite having many of the same pharmacodynamic characteristics and sharing similarities with ibuprofen, flurbiprofen is 5-10 times more toxic, with a lethal dose (LD50) of 10 mg/kg in dogs. 4 In the case of NSAID toxicity, treatment has been limited to supportive and symptomatic treatment, including aggressive decontamination and intravenous fluid administration, as well as the use of gastrointestinal protectant medications, antiemetics and prostaglandin analogues.…”

“…In veterinary medicine, except for research reports indicating that oral administration of flurbiprofen inhibits bone resorption for chronic destructive periodontal disease, pharmaco‐toxicological data are sparse 5,6 . Despite having many of the same pharmacodynamic characteristics and sharing similarities with ibuprofen, flurbiprofen is 5–10 times more toxic, with a lethal dose (LD50) of 10 mg/kg in dogs 4 .…”