Abstract:Flutamide is an oral nonsteroidal antiandrogen drug primarily used to treat prostate cancer. The in vivo metabolism of flutamide was studied in patients with prostate cancer receiving oral dosing (125 mg, thrice daily). Circulating metabolites detected were a side‐chain monohydroxylation metabolite and the amide hydrolysis metabolite and its
N
‐acetyl conjugate. Major metabolites found in urine were side‐chain mono‐ and trihydroxylation metabolites, and the further aryl hydroxylation pr… Show more
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