Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis†

Immunotherapy as an effective tool in allergy treatment

“…The efficacy of immunotherapy in many studies was higher than for results obtained by antihistamines (73) and equivalent to the reduction in clinical symptoms obtained by standard doses of intranasal or inhaled corticosteroids (74)(75)(76)(77)(78)(79)(80). In asthmatic patients (77), the total symptom score after 1 year of treatment with inhaled corticosteroids was reduced by 10% (nonsignificant), and another study (80) showed a reduction in symptoms by 25%.…”

Clinical outcomes and adverse effect monitoring in allergic rhinitis

“…[156][157][158][159] The sparsity of reported adverse events, despite the extensive use of INS over many years, suggests that the clinical safety of these medications is already well established. [160][161][162][163][164] This does not mean, however, that there should not be an awareness of the potential for adverse systemic effects of INS.…”

Antihistamines and nasal blockage

“…The effect on nasal symptoms of other oral antihistamines, such as terfenadine, loratadine, astemizole and azelastine, have been demonstrated by other investigators (14,16,17,22,25,26). Meanwhile, significant increases in histamine, tryptase and leukotriene C4 concentrations in their nasal secretions were evidenced after nasal allergen challenge before and after the treatment.…”

“…When a combination of cetirizine and cimetidine was administered, a significant reduction in the nasal airway resistance and an increase of the nasal air flow were demonstrated after nasal allergen challenge. The effect on nasal symptoms of other oral antihistamines, such as terfenadine, loratadine, astemizole and azelastine, have been demonstrated by other investigators (14,16,17,22,25,26).…”