2011
DOI: 10.5387/fms.57.19
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Fluvastatin Increases Bone Mineral Density in Postmenopausal Women

Abstract: :Although several studies have reported a lower risk of osteoporotic fracture in hypercholesterolemic patients (WHO IIa) treated with statin, longitudinal studies on the effects of statins on bone are lacking. The aim of the present study was to evaluate bone mineral density (BMD) and bone turnover changes induced by 3 -year fluvastatin treatment in postmenopausal women. Twenty -eight consecutive postmenopausal non -diabetic, normotensive hypercholesterolemic women (64.0±3.6 years) were treated for 36 months w… Show more

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Cited by 19 publications
(7 citation statements)
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“…Table 4A -GLM analysis for CTX (ng/mL) at post-intervention, using baseline CTX (ng/ml), group (EX, EXSTAT, STAT), age (years), gender (F, M) and baseline insulin (pmol/L) as independent predictors. [19,20,38]. By contrast, the participants in the present study were not hypercholesterolemic, which might have limited the potential effects of cholesterol reduction on bone turnover.…”
Section: Groupcontrasting
confidence: 49%
“…Table 4A -GLM analysis for CTX (ng/mL) at post-intervention, using baseline CTX (ng/ml), group (EX, EXSTAT, STAT), age (years), gender (F, M) and baseline insulin (pmol/L) as independent predictors. [19,20,38]. By contrast, the participants in the present study were not hypercholesterolemic, which might have limited the potential effects of cholesterol reduction on bone turnover.…”
Section: Groupcontrasting
confidence: 49%
“…However, there are conflicting clinical findings regarding the benefits of this therapy for the treatment of bone diseases, such as osteoporosis. Although some clinical studies show the positive effect of statins on bone mineral density in postmenopausal females, 6 a systematic review of clinical trials, which included data on 3,022 females, does not support the role of statin in preventing fractures or increasing bone density 7 …”
mentioning
confidence: 99%
“…Animal studies support the hypothesis that TZDs induce bone loss characterized by deficient osteoblast function [32,37]. Hydrochlorothiazide, commonly used for the treatment of hypertension [38], and fluvastatin [39], a statin used for prevention of vascular disease, and both prescribed in diabetes patients, have been shown to modestly improve BMD (< 1% for both hydrochlorothiazide and fluvastatin), although there have been no studies to confirm whether this benefit is realized in diabetic patients in light of all their other risk factors.…”
Section: Potential Mechanisms For Riskmentioning
confidence: 62%