Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.

Galus, Ryszard; Sajjad, Emir; Niderla, Justyna; Borowska, Katarzyna; Włodarski, K; Włodarski, Paweł; Jóźwiak, Jarosław

doi:10.2478/v10042-008-0115-3

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…Recently, the role of fluvastatin, a frequently used statin, was examined in modulation of tyrosinase in vitro , which is a key enzyme of melanogenesis synthesis [11,12]. Since these reports suggest that fluvastatin treatment may influence melanin synthesis, hereby we have verified those findings in consecutive experiments in vitro in melanoma cell line and in vivo in mice.…”

Section: Introductionsupporting

confidence: 59%

“…Non-irradiated control cells were maintained in PBS during the time of irradiation procedure. Immediately after second irradiation, PBS was replaced with fresh warm growth medium with/without 1 μM fluvastatin (concentration of fluvastatin was determined by previously performed cell viability assay) [11]. Protein content measurements were done after 24 h following last (second) irradiation.…”

Section: Methodsmentioning

confidence: 99%

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Fluvastatin Influences Hair Color in C57Bl/6 Mice

Galus

Włodarski

Malejczyk

et al. 2013

IJMS

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Our recent in vitro experiments suggest that fluvastatin may influence tyrosinase (key enzyme of melanogenesis) synthesis. The aim of the present study was to verify those findings in experiments, in vitro, in melanoma cell line, and in vivo, in mice. The expression of tyrosinase in B16F10 melanoma cell line, after induction of melanogenesis by UVB irradiation, was examined by Western blot analysis. Afterwards, the effect of fluvastatin on melanin synthesis in hair follicles of C57Bl/6 mice was investigated. The expression of tyrosinase was reduced in the presence of fluvastatin. In mice after anagen induction over the dorsal skin, gel containing fluvastatin in various concentrations was injected subcutaneously, while in part of control groups of mice, gel with placebo was injected. In addition, gel with fluvastatin was injected to four week-old mice (mice in first postnatal anagen) without anagen induction. In extension, injections of gel with fluvastatin or placebo were performed in mice without anagen induction (but after first postnatal anagen). In part of study group of mice (mice after anagen induction and injection of fluvastatin) regrowth of depigmented hair was observed, while in all control groups (mice after injection of placebo), such hair depigmentation over the skin area was not found. In conclusion, this study, for the first time, shows that fluvastatin might affect melanin synthesis in vivo.

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Section: Introductionsupporting

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Fluvastatin Influences Hair Color in C57Bl/6 Mice

Galus

Włodarski

Malejczyk

et al. 2013

IJMS

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“…Additionally, some statins like fluvastatin improve melanogenesis by increasing tyrosinase mRNA production by protein kinase B (Akt/PKB)‐mediated stimulation of α‐melanocyte‐stimulating hormone 26 . Fluvastatin also stimulates tyrosinase activity in UVB‐irradiated B16F10 cell line, thus indicating the photoprotective role of statins 27 . However, these modalities are yet to be described for simvastatin 2 …”

Section: Simvastatin In Vitiligo: Rationale Of Usementioning

confidence: 99%

Simvastatin in vitiligo: an update with recent review of the literature

Hasan¹,

Agarwal

Podder

et al. 2021

Int J Dermatology

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Patients with vitiligo often seek medical attention, as it diminishes their quality of life resulting in significant morbidity. Several topical and systemic therapies are in vogue targeting the immunological aspect of this disease, but results are often unsatisfactory, and complete cure remains elusive. Recently, simvastatin, a 3‐hydroxy‐3‐methylyglutaryl‐coenzyme A (HMG‐CoA) reductase inhibitor, is being evaluated for vitiligo management because of its multimodal action, easy availability, and low cost. The proposed multimodal actions range from anti‐inflammatory, antioxidant, to immunomodulatory properties which may be of therapeutic benefit in vitiligo patients. The authors intend to evaluate the role of simvastatin as a novel therapeutic agent for vitiligo along with relevant review of literature.

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“…B) Espectros de absorção de cabelos loiros e C cabelos pretos antes e após a irradiação. * significativamente diferente a P<0,05 [160]. 1 O 2 pode ser suprimido pela oxidação da melanina, formando melanina oxidada (Mox), ou reação com outros resíduos de aminoácidos (aa), tais como a cisteína da queratina, provocando danos na estrutura do cabelo.…”

Section: Fotossensibilização No Visível Da Melanina Em Cabelounclassified

Efeitos da luz UV-A e visível em células da pele e no cabelo

Chiarelli-Neto¹

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Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.

Cited by 5 publications

References 19 publications

Fluvastatin Influences Hair Color in C57Bl/6 Mice

Fluvastatin Influences Hair Color in C57Bl/6 Mice

Simvastatin in vitiligo: an update with recent review of the literature

Efeitos da luz UV-A e visível em células da pele e no cabelo

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