Fluvoxamine versus desipramine: Comparative polysomnographic effects

Kupfer, David J.; Perel, James M.; Pollock, Bruce G.; Nathan, Rajan; Grochocinski, Victoria J.; Wilson, Melissa; McEachran, Ann B.

doi:10.1016/0006-3223(91)90208-4

Cited by 74 publications

(38 citation statements)

References 19 publications

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“…Similar to Kupfer et al (1991) with the SSRI fluvoxamine, we found that sleep-disturbing effects of fluoxetine occurred in the initial medication phase, i.e., after the single dose of 60 mg, despite the fact that fluoxetine and norfluoxetine plasma levels were only slightly elevated by this dose. This means that sleep continuity could be described as sensitive to the change in plasma levels rather than to the absolute levels.…”

Section: Effects On Sleep Continuity Measuressupporting

confidence: 72%

Fluoxetine and Sleep EEG Effects of a Single Dose, Subchronic Treatment, and Discontinuation in Healthy Subjects

Feige

2002

Neuropsychopharmacology

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In the last years, selective serotonin reuptake inhibitors (SSRIs) have increasingly replaced tricyclics in antidepressive treatment due to their more benign side effect profile. Still, compliance in long-term maintenance therapy often enough is insufficient, since many patients are reluctant to accept daily dosing of antidepressants and thus tend to omit medication sometimes. It is well known for most antidepressants that a discontinu-

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Section: Effects On Sleep Continuity Measuressupporting

confidence: 72%

Fluoxetine and Sleep EEG Effects of a Single Dose, Subchronic Treatment, and Discontinuation in Healthy Subjects

Feige

2002

Neuropsychopharmacology

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“…The same study says that desipramine was associated with shorter sleep latency than fluvoxamine (200 mg). 11 In another study, desipramine (50-250 mg) was associated with more nocturnal waking, shorter sleep, and less efficient sleep than amitriptyline (50-150 mg).…”

Section: Discussionmentioning

confidence: 99%

“…9 Likewise, another study observed that amitriptyline (75 mg) was linked with significantly shorter sleep latency, but more drowsiness than fluoxetine (20 mg). 10 In another study conducted by Kupfer et al, 1991 demonstrated that desipramine (100-200 mg) significantly reduces sleep latency after just one day of treatment but significantly increase again as treatment proceeds. The same study says that desipramine was associated with shorter sleep latency than fluvoxamine (200 mg).…”

Section: Discussionmentioning

confidence: 99%

A prospective study on sleep disorders related to antidepressant drugs use in a tertiary care teaching hospital

Khan

Vishwakarma

Giri

et al. 2015

Int J Basic Clin Pharmacol

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Background: Prescription of antidepressants has been increased from the last decade and responsible for producing sleep disorders as adverse drug reactions (ADRs). Sleep disorders can be divided into 3 large groups: (1) insomnia, (2) primary complaint of daytime sleepiness, and (3) Association of disruptive behaviours during sleep, the disorders of arousal. So active surveillance is needed to access these ADRs. Aims and Objective:To analyze the sleep disturbances as ADRs of various antidepressants prescribed to the patients attending psychiatry outpatient department (OPD). Methods: This prospective study was conducted on patients aged ≤74 years attending Department of Psychiatry OPD and were prescribed Antidepressants for the duration of 8 months (December, 2013-July, 2014. The ADRs reported were confirmed by WHO UMC Causality Assessment Scale. Results: Total number of patients enrolled on the basis of inclusion and exclusion criteria (n=50). Total number of ADRs related to drugs prescribed were found to be n=69. Total number of patients with sleep disturbances as ADRs were found to be n=28. Conclusion:The drug, most frequently implicated to cause sleep disturbances, was mirtazapine. Increased sleep was the most common ADR, found to occur. Unusual ADRs such as sleep talking was also seen.

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“…Since clomipramine has stronger serotonergic reuptake inhibiting effects than other TCAs, it is not surprising that it has the most alerting effects on sleep (30). Thus, clomipramine is probably best described as a serotonergic antidepressant rather than a traditional TCA (27).…”

Section: Tricyclicsmentioning

confidence: 99%

“…Clomipramine and desipramine are 2 ofthe most potent REM-suppressing TCAs, followed by imipramine and nortriptyline (25)(26)(27)(28)(29). Clomipramine, desipramine, and amitriptyline also significantly increase stage I sleep and decrease sleep efficiency over baseline levels (29).…”

Section: Tricyclicsmentioning

confidence: 99%

The Effects of Antidepressants on Sleep in Patients with Depression

Armitage

2000

Can J Psychiatry

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As assessed by laboratory studies, sleep abnormalities in those with major depressive disorders can be classified as difficulties initiating and maintaining sleep, abnormal sleep architecture, and disruptions in the timing of rapid eye movement (REM) sleep. Sleep initiation and maintenance difficulties include prolonged sleep latency (sleep onset insomnia), intermittent wakefulness and sleep fragmentation during the night, early morning awakenings with an inability to return to sleep, reduced sleep efficiency, and decreased total sleep time. With regard to sleep architecture, abnormalities have been reported in the amounts and distribution of nonrapid eye movement (NREM) sleep stages across the night. These include increased light, stage 1 sleep and reductions in the amount ofdeep, slow-wave (stages 3 and 4) sleep. REM sleep disturbances in patients with depression include a short latency (65 minutes) to the first REM sleep, a prolonged first REM sleep period, and increased total REM sleep time, particularly in the first one-half of the night (1-3).Sleep disturbances are generally more prevalent among inpatients with depression (80%), whereas only 40% to 60% of outpatients show sleep abnormalities (4). A recent metaanalysis, however, indicated that no single sleep variable reliably distinguished patients with depression from healthy controls Manuscript

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Fluvoxamine versus desipramine: Comparative polysomnographic effects

Cited by 74 publications

References 19 publications

Fluoxetine and Sleep EEG Effects of a Single Dose, Subchronic Treatment, and Discontinuation in Healthy Subjects

Fluoxetine and Sleep EEG Effects of a Single Dose, Subchronic Treatment, and Discontinuation in Healthy Subjects

A prospective study on sleep disorders related to antidepressant drugs use in a tertiary care teaching hospital

The Effects of Antidepressants on Sleep in Patients with Depression

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