fMLP-OMe Analogs Substituted at the Methionine Residue: An Insight into the Receptor Properties

Abstract

In order to obtain an insight into the mode of binding at the for‐Met‐Leu‐Phe‐OH (fMLP) receptor, three fMLP‐OMe analogs (1–3) were synthesized in which the Met residue was substituted by Gln 1, Asn 2, and Ser 3. We evaluated the influence of the charge variation and/or the shift of its position on neutrophil biological responses.