FMRFamide-related peptides, partial serotonin depletion, and osmoregulation inHelisoma duryi (mollusca: pulmonata)

Khan, H.R.; Price, David A.; Doble, K. E.; Greenberg, Michael J.; Saleuddin, A. S. M.

doi:10.1002/(sici)1096-9861(19980330)393:1<25::aid-cne3>3.0.co;2-s

Cited by 9 publications

(2 citation statements)

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“…Its function is diverse, and includes modulation of feeding behaviour [57], retinal response to light [58], sexual maturation [58], apoptosis [59], osmoregulation [60-63], and regeneration [64-66]. Has-FMRFamide [45] expression levels change dramatically over the semilunar spawning cycle, and between males and females.…”

Section: Discussionmentioning

confidence: 99%

Marked changes in neuropeptide expression accompany broadcast spawnings in the gastropod Haliotis asinina

et al. 2012

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IntroductionA huge diversity of marine species reproduce by synchronously spawning their gametes into the water column. Although this species-specific event typically occurs in a particular season, the precise time and day of spawning often can not be predicted. There is little understanding of how the environment (e.g. water temperature, day length, tidal and lunar cycle) regulates a population’s reproductive physiology to synchronise a spawning event. The Indo-Pacific tropical abalone, Haliotis asinina, has a highly predictable spawning cycle, where individuals release gametes on the evenings of spring high tides on new and full moons during the warmer half of the year. These calculable spawning events uniquely allow for the analysis of the molecular and cellular processes underlying reproduction. Here we characterise neuropeptides produced in H. asinina ganglia that are known in egg-laying molluscs to control vital aspects of reproduction.ResultsWe demonstrate that genes encoding APGWamide, myomodulin, the putative proctolin homologue whitnin, FMRFamide, a schistosomin-like peptide (SLP), a molluscan insulin-related peptide (MIP) and a haliotid growth-associated peptide (HGAP) all are differentially expressed in the anterior ganglia during the two week spawning cycle in both male and female abalone. Each gene has a unique and sex-specific expression profile. Despite these differences, expression levels in most of the genes peak at or within 12 h of the spawning event. In contrast, lowest levels of transcript abundance typically occurs 36 h before and 24 h after spawning, with differences in peak and low expression levels being most pronounced in genes orthologous to known molluscan reproduction neuromodulators.ConclusionsExploiting the predictable semi-lunar spawning cycle of the gastropod H. asinina, we have identified a suite of evolutionarily-conserved, mollusc-specific and rapidly-evolving neuropeptides that appear to contribute to the regulation of spawning. Dramatic increases and decreases in ganglionic neuropeptide expression levels from 36 h before to 24 h after the broadcast spawning event are consistent with these peptides having a regulatory role in translating environmental signals experienced by a population into a synchronous physiological output, in this case, the release of gametes.

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Section: Discussionmentioning

confidence: 99%

Marked changes in neuropeptide expression accompany broadcast spawnings in the gastropod Haliotis asinina

et al. 2012

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“…Invertebrate synapses are clustered onto varicose-like structures that appear as irregular small swellings distributed along neurites. Varicosities have been described in both invertebrate and vertebrate models, such as Helix [7, 17–19], Aplysia [20–24], Lymnaea [25], Helisoma [26], rat cortical neurons [27], pyramidal neurons [28], and hippocampal neurons [29, 30]. …”

Section: Introductionmentioning

confidence: 99%

Synaptic Functions of Invertebrate Varicosities: What Molecular Mechanisms Lie Beneath

2012

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In mammalian brain, the cellular and molecular events occurring in both synapse formation and plasticity are difficult to study due to the large number of factors involved in these processes and because the contribution of each component is not well defined. Invertebrates, such as Drosophila, Aplysia, Helix, Lymnaea, and Helisoma, have proven to be useful models for studying synaptic assembly and elementary forms of learning. Simple nervous system, cellular accessibility, and genetic simplicity are some examples of the invertebrate advantages that allowed to improve our knowledge about evolutionary neuronal conserved mechanisms. In this paper, we present an overview of progresses that elucidates cellular and molecular mechanisms underlying synaptogenesis and synapse plasticity in invertebrate varicosities and their validation in vertebrates. In particular, the role of invertebrate synapsin in the formation of presynaptic terminals and the cell-to-cell interactions that induce specific structural and functional changes in their respective targets will be analyzed.

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Physiological functions of FMRFamide‐like peptides (FLPs) in crustaceans

Mercier

Friedrich

Boldt

2003

Microscopy Res & Technique

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FMRFamide-related peptides, partial serotonin depletion, and osmoregulation inHelisoma duryi (mollusca: pulmonata)

Cited by 9 publications

References 31 publications

Marked changes in neuropeptide expression accompany broadcast spawnings in the gastropod Haliotis asinina

Marked changes in neuropeptide expression accompany broadcast spawnings in the gastropod Haliotis asinina

Synaptic Functions of Invertebrate Varicosities: What Molecular Mechanisms Lie Beneath

Physiological functions of FMRFamide‐like peptides (FLPs) in crustaceans

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