fMRI during affect discrimination in bipolar affective disorder

Yurgelun‐Todd, Deborah; Gruber, Staci A.; Kanayama, Gen; Killgore, William D. S.; Baird, Abigail A.; Young, Ashley D.

doi:10.1034/j.1399-5618.2000.20304.x

Cited by 330 publications

(184 citation statements)

References 68 publications

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“…Further supporting this notion, several investigators have observed increased activation in other components of the anterior limbic network, including striatum, thalamus and amygdala, in patients with bipolar disorder during mood episodes, particularly mania, but also depression. 64,68,74 Many of these abnormalities appear to be mood state dependent and relatively few studies of carefully defined euthymic patients have been reported that might clarify potential 'trait' functional abnormalities. As noted, we have observed activation in cortical areas during euthymia that might serve to compensate for a baseline over-reactive brain networks that subserve emotion, 84,85,70 and which could represent a trait characteristic if validated in larger studies.…”

Section: Discussionmentioning

confidence: 99%

“…The mood states of the patients were not clearly delineated in this study, although average Young Mania Rating Scale and Hamilton Depression Scale ratings were low. Yurgelun-Todd et al 68 found that bipolar patients performing a facial affect discrimination task showed decreased dorsolateral prefrontal cortical activation, when presented with fearful faces. Mood ratings in this study appeared to vary widely, complicating study interpretation.…”

Section: Prefrontal Cortical Activationmentioning

confidence: 99%

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The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings

2004

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The authors review existing structural and functional neuroimaging studies of patients with bipolar disorder and discuss how these investigations enhance our understanding of the neurophysiology of this illness. Findings from structural magnetic resonance imaging (MRI) studies suggest that some abnormalities, such as those in prefrontal cortical areas (SGPFC), striatum and amygdala exist early in the course of illness and, therefore, potentially, predate illness onset. In contrast, other abnormalities, such as those found in the cerebellar vermis, lateral ventricles and other prefrontal regions (eg, left inferior), appear to develop with repeated affective episodes, and may represent the effects of illness progression and associated factors. Magnetic resonance spectroscopy investigations have revealed abnormalities of membrane and second messenger metabolism, as well as bioenergetics, in striatum and prefrontal cortex. Functional imaging studies report activation differences between bipolar and healthy controls in these same anterior limibic regions. Together, these studies support a model of bipolar disorder that involves dysfunction within subcortical (striatalthalamic)-prefrontal networks and the associated limbic modulating regions (amygdala, midline cerebellum). These studies suggest that, in bipolar disorder, there may be diminished prefrontal modulation of subcortical and medial temporal structures within the anterior limbic network (eg, amygdala, anterior striatum and thalamus) that results in dysregulation of mood. Future prospective and longitudinal studies focusing on these specific relationships are necessary to clarify the functional neuroanatomy of bipolar disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Prefrontal Cortical Activationmentioning

confidence: 99%

The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings

2004

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“…A similar pattern has been reported by Jogia et al, (2008), who found a reduced right ventrolateral PFC activation in BD patients with manic symptoms compared to healthy controls during recognition of sad facial expressions. Further evidence for right frontal dysfunction in mania has been suggested by an fMRI study revealing decreased right-sided activation in the dorsolateral region of the PFC in BD patients with manic symptoms while identifying fearful expressions in a facial emotion task (Killgore et al, 2000).…”

Section: Introductionmentioning

confidence: 93%

“…Emotional dysregulation in BD has also been linked to atypical functional hemispheric asymmetries as shown by neuroimaging studies (Yurgelun-Todd et al, 2000;Foland et al, 2008;Killgore et al, 2008;Strakowski et al, 2011;Liu et al, 2012) suggesting a deviation from the typical right hemisphere advantage in emotion perception. For example, Killgore et al, (2008) found a decrease in right inferior orbitofrontal activation in BD patients with manic symptoms during passive viewing of a series of black and white fearful facial expressions.…”

Section: Introductionmentioning

confidence: 96%

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Najt

Hausmann

2014

Psychiatry Research

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“…Structural MRI (sMRI) studies in bipolar adults find either increased or unchanged amygdala volume relative to controls (8)(9)(10), whereas functional MRI (fMRI) studies find that adults with BD, relative to controls, have either amygdala hyperactivation (11,37) or hypoactivation (12) in response to facial stimuli. In contrast to adult data, sMRI studies in bipolar children consistently document decreased amygdala volume in patients compared with controls (13)(14)(15)(16)(17).…”

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confidence: 99%

Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder

Rich

Vinton

Roberson‐Nay

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

280

303

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Reflecting a paradigm shift in clinical neuroscience, many chronic psychiatric illnesses are now hypothesized to result from perturbed neural development. However, most work in this area focuses on schizophrenia. Here, we extend this paradigm to pediatric bipolar disorder (BD), thus demonstrating traction in the developmental psychobiology perspective. To study amygdala dysfunction, we examined neural mechanisms mediating face processing in 22 youths (mean age 14.21 ؎ 3.11 yr) with BD and 21 controls of comparable age, gender, and IQ. Event-related functional MRI compared neural activation when attention was directed to emotional aspects of faces (hostility, subjects' fearfulness) vs. nonemotional aspects (nose width). Compared with controls, patients perceived greater hostility in neutral faces and reported more fear when viewing them. Also, compared with controls, patients had greater activation in the left amygdala, accumbens, putamen, and ventral prefrontal cortex when rating face hostility, and greater activation in the left amygdala and bilateral accumbens when rating their fear of the face. There were no between-group behavioral or neural differences in the nonemotional conditions. Results implicate deficient emotion-attention interactions in the pathophysiology of BD in youth and suggest that developmental psychobiology approaches to chronic mental illness have broad applicability.amygdala ͉ faces ͉ functional MRI R ecently, psychology and psychiatry have witnessed a major paradigm shift: virtually all chronic adult mental illnesses are now thought to result from long-term perturbations in neural development. Two lines of research support this perspective: family-based͞longitudinal studies and neurobiological studies. Family-based and longitudinal studies implicate developmental perturbations in a range of conditions, including behavior disorders, substance abuse, mood disorders, and psychoses (1-3). However, virtually all research on developmental neurobiology focuses on schizophrenia, where data implicate a neural circuit connecting the dorsolateral prefrontal cortex, striatum, and hippocampus (4, 5). Neurocognitive correlates of schizophrenia, such as deficient working memory, are thought to result from dysfunction in this circuit (6). An important next step is the extension of the developmental neurobiological approach to other mental illnesses and other neural systems associated with information processing and emotion regulation.For several reasons, bipolar disorder (BD) is an ideal illness in which to expand the emerging developmental paradigm by conducting neurobiologically oriented developmental research. BD causes marked disruption in social, academic, and family function. Major questions persist concerning the boundaries of the condition in children; neurobiological data might ultimately resolve them. Most importantly, research in adult patients and animals implicates a circuit encompassing the amygdala, striatum, and ventral prefrontal cortex (VPFC) in the pathophysiology of BD (7). This circu...

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fMRI during affect discrimination in bipolar affective disorder

Abstract: These findings are consistent with the hypothesis that in some patients with bipolar affective disorder, there may be a reduction of frontal cortical function which may be associated with affective as well as attentional processing deficits.

Cited by 330 publications

References 68 publications

The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings

The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder

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