fMRI Measurement of Brain Dysfunction in Alcohol-Dependent Young Women

Tapert, Susan F.; Brown, Gregory G.; Kindermann, Sandra S.; Cheung, E.; Frank, Lawrence R.; Brown, Sandra A.

doi:10.1097/00000374-200102000-00012

Cited by 113 publications

(166 citation statements)

References 33 publications

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“…Further, estimates of typical blood-alcohol concentration achieved were negatively associated with parietal response among MJ teens, which could indicate that heavier drinking MJ teens may demonstrate less neural compensation or be less likely to utilize spatial strategies relative to those with lighter alcohol use histories. This is consistent with previous findings of diminished parietal activation during SWM among young adults with alcohol use disorders (Tapert et al, 2001), and suggests a potential interaction between heavy alcohol and marijuana use in youth (Schweinsburg et al, 2005b).…”

Section: Discussionsupporting

confidence: 92%

“…MJ teens in this study exhibited moderately heavy alcohol use, and our previous work has suggested alcohol-related neural dysfunction during this SWM task among heavy drinkers (Tapert et al, 2001(Tapert et al, , 2004. Thus, we performed regressions to examine whether BOLD response differences among MJ teens might be related to frequency, quantity, duration, or recency of alcohol use.…”

Section: Fmri Responsementioning

confidence: 88%

“…Parents were given the Child Behavior Checklist (Achenbach and Rescorla, 2001) to assess level of psychopathological syndromes. (Tapert et al, 2001;Kindermann et al, 2004) consisted of 18 21-s blocks that alternated between baseline vigilance and working memory conditions, and three blocks of resting fixation (21 s at the beginning and end of scanning, and 42 s in the middle of the task). The task began with 6 s of blank screen to allow the scanner to reach steady state; total scanning time was 7 min 48 s. Each block began with a 1-s word cue that indicated the type of upcoming block.…”

Section: State and Behavioral Measures-thementioning

confidence: 99%

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Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

Schweinsburg¹,

Nagel²,

Schweinsburg³

et al. 2008

Psychiatry Research: Neuroimaging

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172

168

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Marijuana is the most widely used illicit substance among teenagers, yet little is known about the possible neural influence of heavy marijuana use during adolescence. We previously demonstrated an altered functional magnetic resonance imaging (fMRI) activity related to spatial working memory (SWM) among adolescents who were heavy users of after an average of 8 days of abstinence, but the persisting neural effects remain unclear. To characterize the potentially persisting neurocognitive effects of heavy marijuana use in adolescence, we examined fMRI response during SWM among abstinent marijuana-using teens. Participants were 15 MJ teens and 17 demographically similar nonusing controls, ages 16-18. Teens underwent biweekly urine toxicology screens to ensure abstinence for 28 days before fMRI acquisition. Groups performed similarly on the SWM task, but MJ teens demonstrated lower activity in right dorsolateral prefrontal and occipital cortices, yet significantly more activation in right posterior parietal cortex. MJ teens showed abnormalities in brain response during a SWM task compared with controls, even after 1 month of abstinence. The activation pattern among MJ teens may reflect different patterns of utilization of spatial rehearsal and attention strategies, and could indicate altered neurodevelopment or persisting abnormalities associated with heavy marijuana use in adolescence.

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Section: Discussionsupporting

confidence: 92%

Section: Fmri Responsementioning

confidence: 88%

Section: State and Behavioral Measures-thementioning

confidence: 99%

See 1 more Smart Citation

Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

Schweinsburg¹,

Nagel²,

Schweinsburg³

et al. 2008

Psychiatry Research: Neuroimaging

Self Cite

172

168

View full text Add to dashboard Cite

show abstract

“…Spatial working memory task-The SWM task (Kindermann et al, 2004;Tapert et al, 2001) consisted of eighteen 20-s blocks alternating between SWM and simple attention baseline conditions, and three rest blocks (total time = 7:48 minutes). During the SWM condition, abstract line drawings were presented sequentially in varied locations.…”

Section: Neuropsychological and Behavioral Measures-onmentioning

confidence: 99%

fMRI response to spatial working memory in adolescents with comorbid marijuana and alcohol use disorders

Schweinsburg

Cheung

et al. 2005

Drug and Alcohol Dependence

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112

130

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Alcohol and marijuana use are prevalent in adolescence, yet the neural impact of concomitant use remains unclear. We previously demonstrated functional magnetic resonance imaging (fMRI) response to spatial working memory (SWM) among teens with alcohol use disorders (AUD) compared to controls, and predicted that adolescents with marijuana and alcohol use disorders would show additional abnormalities.Participants were three groups of 15−17-year-olds: 19 non-abusing controls, 15 AUD teens with limited exposure to drugs, and 15 teens with comorbid marijuana and alcohol use disorders (MAUD) and minimal other drug experience. After >2 days' abstinence, participants performed a SWM task during fMRI acquisition. fMRI brain response patterns differed between groups, despite similar performance on the task. MAUD youths showed less activation in inferior frontal and temporal regions than controls, and more response in other prefrontal regions. Compared to AUD teens, MAUD youths also showed less inferior frontal and temporal activation, but more medial frontal response. Overall, MAUD youths showed different brain response abnormalities than teens with AUD alone, despite relatively short histories of substance involvement. This pattern could suggest compensation for marijuana-related attention and working memory deficits. However, relatively recent use and premorbid features may influence results, and should be examined in future studies.

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“…Studies performed with alcoholics showed that frequent binge drinking also produces serious memory deficits in the long run (eg Tapert et al, 2001). Moreover, a recent study performed in rats showed that even after a 4-day period of continuous binge drinking, significant corticolimbic neural cell loss was observed (Obernier et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Alcohol Hangover Effects on Memory Functioning and Vigilance Performance after an Evening of Binge Drinking

Verster

Duin

Volkerts

et al. 2002

Neuropsychopharmacol

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The impairing effects on memory functioning after acute alcohol intoxication in healthy volunteers and after chronic use in alcoholics are well established. However, research determining the next-morning effects of a single episode of binge drinking on memory functioning is scarce. A total of 48 healthy volunteers participated in a single-blind study comprising an evening (baseline) session, followed by a treatment administration (ethanol 1.4 g/kg or placebo), and a morning session. Memory was tested with a word-learning test (including immediate and delayed recall, and recognition). Further, a 45-min Mackworth clock test for measuring vigilance was included (parameters: number of hits and false alarms) and subjective alertness was assessed, to infer whether word-learning test findings reflect sedation or specific memory impairments. Delayed recall in the morning session was significantly worse in the alcohol group when compared to the placebo group (F 1,42 ¼ 6.0, po0.02). In contrast, immediate recall and recognition were unimpaired in the alcohol group. In the morning session, relative to the placebo group, subjective alertness was significantly reduced in the alcohol group before and after the tests (F 1,44 ¼ 8.7, po0.005; F 1,44 ¼ 13.3, po0.001, respectively). However, in the Mackworth clock test, the alcohol group and placebo group did not differ significantly in the morning session. The specific findings of impaired delayed recall show that memory retrieval processes are significantly impaired during alcohol hangover. Vigilance performance was not significantly affected, indicating that this memory impairment does not reflect sedation.

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fMRI Measurement of Brain Dysfunction in Alcohol-Dependent Young Women

Cited by 113 publications

References 33 publications

Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

fMRI response to spatial working memory in adolescents with comorbid marijuana and alcohol use disorders

Alcohol Hangover Effects on Memory Functioning and Vigilance Performance after an Evening of Binge Drinking

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