FMRI Visualization of Brain Activity during a Monetary Incentive Delay Task

Knutson, Brian; Westdorp, Andrew F.; Kaiser, Erica; Hommer, Daniel W.

doi:10.1006/nimg.2000.0593

Cited by 1,265 publications

(1,212 citation statements)

References 34 publications

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“…As S− cues are not rewarded, the signal obtained for those responses cannot be driven by the reward itself, making a reward expectation account a plausible alternative. Our findings are consistent with several human neuroimaging studies showing an activation of the NAc during the anticipatory phase of a monetary incentive delay task (Ernst et al, 2004;Kirsch et al, 2003;Knutson et al, 2000). A straightforward acceptance of the reward anticipation account is somewhat challenged by the lack of significant increase in NAc O 2 signal following incorrect lever choice to the S+.…”

Section: Nucleus Accumbens Activation and Reward Anticipationsupporting

confidence: 90%

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

et al. 2012

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a b s t r a c t a r t i c l e i n f oReal-time in vivo oxygen amperometry, a technique that allows measurement of regional brain tissue oxygen (O 2 ) has been previously shown to bear relationship to the BOLD signal measured with functional magnetic resonance imaging (fMRI) protocols. In the present study, O 2 amperometry was applied to the study of reward processing in the rat nucleus accumbens to validate the technique with a behavioural process known to cause robust signals in human neuroimaging studies. After acquisition of a cued-lever pressing task a robust increase in O 2 tissue levels was observed in the nucleus accumbens specifically following a correct lever press to the rewarded cue. This O 2 signal was modulated by cue reversal but not lever reversal, by differences in reward magnitudes and by the motivational state of the animal consistent with previous reports of the role of the nucleus accumbens in both the anticipation and representation of reward value. Moreover, this modulation by reward value was related more to the expected incentive value rather than the hedonic value of reward, also consistent with previous reports of accumbens coding of "wanting" of reward. Altogether, these results show striking similarities to those obtained in human fMRI studies suggesting the use of oxygen amperometry as a valid surrogate for fMRI in animals performing cognitive tasks, and a powerful approach to bridge between different techniques of measurement of brain function.

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Section: Nucleus Accumbens Activation and Reward Anticipationsupporting

confidence: 90%

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

et al. 2012

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“…The implication of the OFC/IFG in subjective sensitivity to gradients in monetary value is consistent with a previously suggested role for the OFC in the processing of relative reward in the healthy state (Breiter et al, 2001;Elliott et al, 2003;Kringelbach et al, 2003;Knutson et al, 2000;O'Doherty et al, 2001). Given the additional role of the OFC in emotional suppression (Beauregard et al, 2001;Levesque et al, 2003), and the uniqueness of this brain-behavior correlation to the cocaine abusers only, findings further suggest the impact on results of competing, extraneous or idiosyncratic factors (Montague and Berns, 2002).…”

Section: The Ofc/ifg In the Constrained Subjective Sensitivity To Relsupporting

confidence: 86%

“…In particular, OFC neurons discriminate between different rewards based on the relative preferences exhibited in overt behavior (Tremblay and Schultz, 1999). In analogous human functional neuroimaging studies in healthy subjects, the OFC responds maximally to extremes of a reward range (including best outcome versus worse outcome) (Elliott et al, 2003;O'Doherty et al, 2001), demonstrating an association with the reinforcer's relative magnitude (Knutson et al, 2000;Breiter et al, 2001) or its subjective pleasantness (Kringelbach et al, 2003). In drug addiction, we separately reported lack of a graded (i.e., relative) OFC response to monetary reward in cocaine abusers as compared to matched healthy control subjects (Goldstein et al, in press), providing experimental evidence for the central role of OFC dysfunction in reward processing and inhibitory control (i.e., Impaired Response Inhibition and Salience Attribution, I-RISA) in this disorder (Goldstein and Volkow, 2002).…”

Section: Introductionmentioning

confidence: 99%

Subjective sensitivity to monetary gradients is associated with frontolimbic activation to reward in cocaine abusers

Goldstein

Tomasi

Alia‐Klein

et al. 2007

Drug and Alcohol Dependence

107

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Drug addiction is characterized by marked disruptions in the ability to process reward. Here we evaluated in cocaine addicted and healthy control participants the subjective sensitivity to reward gradients and its association with neural responses to sustained reward. A self-report questionnaire was used to assess the former. A functional magnetic resonance imaging task that utilized monetary reward as feedback in a blocked design was used to assess the latter. Results revealed that whereas control subjects valued high money more than low money, over half of the cocaine addicted subjects valued all monetary amounts equally. This compromised subjective sensitivity to gradients in reward value was significantly correlated with higher activations to money in the lateral orbitofrontal cortex/inferior frontal gyrus (BA 47) and amygdala, and lower activations in the middle frontal gyrus (BA 6), which together explained 85% of the variability on this rating scale in the cocaine abusers only. These results provide for the first time evidence of restricted subjective sensitivity to gradients of reward in cocaine addiction and of the involvement of frontolimbic brain regions (including the orbitofrontal cortex) in this deficit.

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“…Dorsal striatal (caudate and putamen) activity is regularly reported in human imaging studies of both rewards and punishments (Delgado et al, 2000(Delgado et al, , 2003Elliott et al, 2004;Knutson et al, 2000Knutson et al, , 2001O'Doherty et al, 2002O'Doherty et al, , 2004Pagnoni et al, 2002), thus striatal activity in the current task may relate to feelings of self-punishment. For instance, in one of our scenarios we focused on being rejected for a job.…”

Section: Role Of Striatal Activity In Self-criticismmentioning

confidence: 98%

Having a word with yourself: Neural correlates of self-criticism and self-reassurance

et al. 2010

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Self-criticism is strongly correlated with a range of psychopathologies, such as depression, eating disorders and anxiety. In contrast, self-reassurance is inversely associated with such psychopathologies. Despite the importance of self-judgements and evaluations, little is known about the neurophysiology of these internal processes. The current study therefore used a novel fMRI task to investigate the neuronal correlates of selfcriticism and self-reassurance. Participants were presented statements describing two types of scenario, with the instruction to either imagine being self-critical or self-reassuring in that situation. One scenario type focused on a personal setback, mistake or failure, which would elicit negative emotions, whilst the second was of a matched neutral event. Self-criticism was associated with activity in lateral prefrontal cortex (PFC) regions and dorsal anterior cingulate (dAC), therefore linking self-critical thinking to error processing and resolution, and also behavioural inhibition. Self-reassurance was associated with left temporal pole and insula activation, suggesting that efforts to be self-reassuring engage similar regions to expressing compassion and empathy towards others. Additionally, we found a dorsal/ventral PFC divide between an individual's tendency to be self-critical or self-reassuring. Using multiple regression analyses, dorsolateral PFC activity was positively correlated with high levels of self-criticism (assessed via self-report measure), suggesting greater error processing and behavioural inhibition in such individuals. Ventrolateral PFC activity was positively correlated with high self-reassurance. Our findings may have implications for the neural basis of a range of mood disorders that are characterised by a preoccupation with personal mistakes and failures, and a self-critical response to such events.

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FMRI Visualization of Brain Activity during a Monetary Incentive Delay Task

Cited by 1,265 publications

References 34 publications

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

Subjective sensitivity to monetary gradients is associated with frontolimbic activation to reward in cocaine abusers

Having a word with yourself: Neural correlates of self-criticism and self-reassurance

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