FMTVDM – FHRWW & BEST ©℗ The First True “Quantitative” Nuclear Imaging Protocols with Proprietary Equations following The Fleming Method (TFM) for Nuclear Scintillation Equipment Quantitative Standardization

Abstract

Case study 1The Fleming Method for Tissue and Vascular Differentiation and Metabolism (FMTVDM©℗) using same state single or sequential quantification comparisons [1-15] "True Quantification" of Cardiac Disease using Myocardial Perfusion Imaging following Single Injection of Tc99m Isotope (Sestamibi) and "True Quantification" Measurement of Isotope Redistribution.

Theranostic Information Provided by FMTVDM ©ⓟ; B.E.S.T ©ⓟ. Imaging

“…With the introduction of FMTVDM; B.E.S.T. Imaging, absolute true "quantification" of both cardiac and oncologic imaging now exists [1][2][3][4][5][6][7][8][9].…”

“…Until quite recently, diagnostic imaging has relied upon "qualitative" imaging limited by the ability to define disease as either present or absent. The first marker that you are using a "qualitative" test is a discussion of sensitivity, the ability to find disease when present and specificity, the ability to exclude disease when absent [1][2][3][4][5][6][7][8][9]. This yes/no approach to medicine reflects the limitations qualitatively imposed upon us despite the understanding that tissues don't simply exist in either a "normal" or "diseased" state but rather a transition occurs as the genetic and environmental factors influencing tissues results in transitional changes, transitional changes which can now be fully appreciated and measured [1][2][3][4][5][6][7][8][9].…”

“…The quantitative ability (FMTVDM© ⓟ; B.E.S.T.© ⓟ Imaging) to measure changes in regional blood flow and tissue metabolism [1][2][3][4][5][6][7][8][9] now makes it possible to differentiate several changes in tissue type; recognizing a "Health-Spectrum" defined by The interaction between cellular genetics and environmental factors consequently influence changes in tissue resulting in transitional changes including regional blood flow differences and metabolism. At one end of the spectrum is the absence of life, which may or may not be associated with a significant accumulation of cellular debris, inter alia, calcium, which may occur prior to the actual loss of cellular "life".…”

FMTVDM/BEST©℗ Imaging for Women with Breast Implants and Dense Breasts

“…Prior to FMTVDM/BEST Imaging, diagnostic testing was limited to looking for breast cancer either using "qualitative" imaging defining disease as either present or absent, or semiquantitative methods [1][2][3][4][5][6][7][8][9][10] which is also limited to the same yes you have breast cancer or no you don't interpretation. These imaging methods include mammography, ultrasound, CT, MRI, as well as other SPECT/Planar and PET imaging approaches and as such are with associated sensitivity and specificity problems.…”

FMTVDM/BEST Imaging Equally Applicable for Male Breast Cancer

“…In order of increasing regional blood flow and cellular metabolism are what is considered to be the "normal" state of a given tissue; resulting changes occurring due to an increased signaling and consequential accumulation of an inflammatory state; sequentially followed by further changes in tissue transitioning through increasingly metabolically active tissue with increased metabolic activity and demands for increased regional blood flow, until arriving at a tissue state where the expected controls and functionality of tissue no longer exist; what has classically been defined as "cancer". Implicit in this understanding is the appreciation that this continuum across transitional states reflects the interrelationship between these various "Health-Spectrum" states, which (1) Are not defined by some arbitrary absolute cutoffs between tissue states, (2) Demonstrate the ability of tissues to transition in either direction towards "normalization" or towards "cancer" and (3) Allow for the absolute measurement of the effect of treatment upon any of these tissue states across the "Health-Spectrum" providing the ability to direct care at the "patient-specific" level, improving outcomes across Prior to FMTVDM/BEST Imaging, diagnostic testing was limited to looking for breast cancer either using "qualitative" imaging defining disease as either present or absent, or semiquantitative methods [1][2][3][4][5][6][7][8][9][10] which is also limited to the same yes you have breast cancer or no you don't interpretation. These imaging methods include mammography, ultrasound, CT, MRI, as well as other SPECT/Planar and PET imaging approaches and as such are associated with sensitivity and specificity problems.…”