FNAC aided diagnosis of clear cell sarcoma of kidney: Report of two cases in infants

Abstract

Clear cell sarcoma of kidney (CCSK) is a rare aggressive malignant renal neoplasm with a high metastatic potential. Its outcome has however, improved with the advent of doxorubicin based neoadjuvant chemotherapy. Here, we present two cases of CCSK in infants diagnosed on cytology followed by nephrectomy. The first case presented in the neonatal period and had the unusual histological finding of islands of cartilage. The second case presented at the age of eight months. The possibility of CCSK should, therefore, be considered in the differential diagnoses of renal masses in infants as well as neonates. Diagn. Cytopathol. 2017;45:761-765. © 2017 Wiley Periodicals, Inc.

Utility of cell block preparation in diagnosis of paediatric abdominal neoplasms

“…IHC on CB in CCSK shows strong paranuclear dot like positivity for vimentin. The pale appearance of slides, hypocellularity, myxoid stroma and careful assessment of cellular details can reliably differentiate between the two, as we have reported earlier 9 . The most common benign tumour in our series was CMN 10 .…”