FNIII14 Peptide-Enriched Membrane Nanocarrier to Disrupt Stromal Barriers through Reversing CAFs for Augmenting Drug Penetration in Tumors

Liu, Zhenan; Ji, Ping; Liu, Hanzhe; Yu, Lili; Zhang, Shi-Man; Liu, Pan; Zhang, Xian-Zheng; Luo, Guo-Feng; Shang, Zhengjun

doi:10.1021/acs.nanolett.3c02983

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…This made the NPs can respond to FAP and induce the combination of FINIII4 and integrin β1 to disrupt the functions of CAFs to decrease the density of tumor. 230…”

Section: Disrupting Caf Functionmentioning

confidence: 99%

The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts

Huang,

Ge,

et al. 2024

IJN

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Cancer-associated fibroblasts (CAF) are the most abundant stromal cells in the tumor microenvironment (TME), especially in solid tumors. It has been confirmed that it can not only interact with tumor cells to promote cancer progression and metastasis, but also affect the infiltration and function of immune cells to induce chemotherapy and immunotherapy resistance. So, targeting CAF has been considered an important method in cancer treatment. The rapid development of nanotechnology provides a good perspective to improve the efficiency of targeting CAF. At present, more and more researches have focused on the application of nanoparticles (NPs) in targeting CAF. These studies explored the effects of different types of NPs on CAF and the multifunctional nanomedicines that can eliminate CAF are able to enhance the EPR effect which facilitate the anti-tumor effect of themselves. There also exist amounts of studies focusing on using NPs to inhibit the activation and function of CAF to improve the therapeutic efficacy. The application of NPs targeting CAF needs to be based on an understanding of CAF biology. Therefore, in this review, we first summarized the latest progress of CAF biology, then discussed the types of CAF-targeting NPs and the main strategies in the current. The aim is to elucidate the application of NPs in targeting CAF and provide new insights for engineering nanomedicine to enhance immune response in cancer treatment.

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“…This made the NPs can respond to FAP and induce the combination of FINIII4 and integrin β1 to disrupt the functions of CAFs to decrease the density of tumor. 230…”

Section: Disrupting Caf Functionmentioning

confidence: 99%

The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts

Huang,

Ge,

et al. 2024

IJN

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“…Peptide FNIII14, due to its novel mechanism targeting integrins, might become a promising senotherapeutic agent. While one intrinsic drawback of peptide drugs is their low bioavailability due to their susceptibility to enzymatic degradation in vivo [ 213 ], technology for a drug delivery nanosystem for peptide FNIII14 suitable for in vivo applications has recently been developed [ 214 ]. Further progress in consideration of clinical applications is expected.…”

Section: Potential Strategies Targeting Cellular Senescence By Blocki...mentioning

confidence: 99%

Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases

Fujita,

Sasada,

Iyoda

et al. 2024

IJMS

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Senescence is a physiological and pathological cellular program triggered by various types of cellular stress. Senescent cells exhibit multiple characteristic changes. Among them, the characteristic flattened and enlarged morphology exhibited in senescent cells is observed regardless of the stimuli causing the senescence. Several studies have provided important insights into pro-adhesive properties of cellular senescence, suggesting that cell adhesion to the extracellular matrix (ECM), which is involved in characteristic morphological changes, may play pivotal roles in cellular senescence. Matricellular proteins, a group of structurally unrelated ECM molecules that are secreted into the extracellular environment, have the unique ability to control cell adhesion to the ECM by binding to cell adhesion receptors, including integrins. Recent reports have certified that matricellular proteins are closely involved in cellular senescence. Through this biological function, matricellular proteins are thought to play important roles in the pathogenesis of age-related diseases, including fibrosis, osteoarthritis, intervertebral disc degeneration, atherosclerosis, and cancer. This review outlines recent studies on the role of matricellular proteins in inducing cellular senescence. We highlight the role of integrin-mediated signaling in inducing cellular senescence and provide new therapeutic options for age-related diseases targeting matricellular proteins and integrins.

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Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy^†

Luo,

Chen,

Zhang

2024

Chin. J. Chem.

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Comprehensive SummaryTumor stroma composing diverse extracellular matrixes (ECM) and stromal cells shapes a condensed physical barrier, which severely hampers the efficient accessibility of nanomedicine to tumor cells, especially these deep‐seated in the core of tumor. Such barrier significantly compromises the antitumor effects of drug‐loaded nanomedicine, revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration ability. To achieve this goal, various nanoparticle‐based strategies have been developed, including direct depleting ECM components via delivering anti‐fibrotic agents or targeting stromal cells to suppress ECM expression, dynamic regulation of nanoparticles’ physicochemical properties (i.e., size, surface charge, and morphology), mechanical force‐driven deep penetration, and natural/biomimetic self‐driven nanomedicine. All these nanostrategies were systemically summarized in this review, and the design principles for obtaining admirable nanomedicine were included. With the rapid development of nanotechnology, elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies, such as chemotherapy, photodynamic therapy, and immunotherapy.This article is protected by copyright. All rights reserved.

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FNIII14 Peptide-Enriched Membrane Nanocarrier to Disrupt Stromal Barriers through Reversing CAFs for Augmenting Drug Penetration in Tumors

Cited by 6 publications

References 40 publications

The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts

The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts

Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy^†

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FNIII14 Peptide-Enriched Membrane Nanocarrier to Disrupt Stromal Barriers through Reversing CAFs for Augmenting Drug Penetration in Tumors

Cited by 6 publications

References 40 publications

The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts

The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts

Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy†

Contact Info

Product

Resources

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Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy^†