fNIRS Studies on Hemispheric Asymmetry in Atypical Neural Function in Developmental Disorders

Doi, Hiroyuki; Shinohara, Kazuyuki

doi:10.3389/fnhum.2017.00137

Cited by 22 publications

(22 citation statements)

References 66 publications

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“…This observation might confirm atypical brain laterality observed earlier in adult patients with ADHD (right hemisphere deficit) (Mohamed et al 2015). Moreover, a recent review of fNIRS studies has reported that right hemisphere asymmetry in atypical neuronal function was found in children with ADHD (Doi and Shinohara 2017). Another longitudinal study has shown that healthy children progressively developed normal lateralisation of the right frontal cortex and left occipital cortex during development, although this normal lateralisation would be disrupted for ADHD children (Shaw et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…TH was proposed as a marker because this rate-limiting enzyme of the dopamine synthesis is down-regulated in the PFC of SHRs (Viggiano et al 2004) and human ADHD patients, and dopamine is essential for proper functioning of the PFC (Arnsten 2009). As many of the brain abnormalities were reported in one of the brain hemispheres only (Rubia et al 1999; Shaw et al 2009; Silk et al 2016; Doi and Shinohara 2017), both left and right hemispheres were investigated. Considering that brain abnormalities associated with ADHD manifest in pre-pubertal SHRs (5-week-old) and they often disappear in maturing SHRs (10-week-old) (Hsu et al 2010), any abnormalities in studied biologically active substances contents due to ADHD should be observed before puberty.…”

Section: Introductionmentioning

confidence: 99%

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ADHD pathogenesis in the immune, endocrine and nervous systems of juvenile and maturating SHR and WKY rats

et al. 2019

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RationaleAttention-deficit/hyperactivity disorder (ADHD) is one of the most common neurobehavioural disorders with morphological and functional brain abnormalities. However, there is a growing body of evidence that abnormalities in the immune and endocrine systems may also account for the ADHD pathogenesis.ObjectivesTo test ADHD pathogenesis in neurological, immune and endocrine systems, this study examined the concentrations of cytokines, chemokines, oxidative stress markers, metabolic parameters, steroid hormones and steroidogenic enzymes in the serum and/or tissues of spontaneously hypertensive rats (SHRs, animal model of ADHD) and Wistar Kyoto rats (WKYs, control animals). Moreover, the volume of the medial prefrontal cortex (mPFC) as well as the density of dopamine 2 (D2) receptor-expressing cells and tyrosine hydroxylase (TH)-positive nerve fibres in it was also elucidated.MethodsPeripheral blood, spleen and adrenal gland samples, as well as brain sections collected on day 35 (juvenile) and day 70 (maturating) from SHRs and WKYs, were processed by ELISA and immunohistochemistry, respectively.ResultsThe results show significant increases of serum and/or tissue concentrations of cytokines, chemokines and oxidative stress markers in juvenile SHRs when compared to the age-matched WKYs. These increases were accompanied by a lowered volume of the mPFC and up-regulation of D2 in this brain region. In maturating SHRs, the levels of inflammatory and oxidative stress markers were normalised and accompanied by elevated contents of steroid hormones.ConclusionsSignificant elevations of serum and/or tissue contents of cytokines, chemokines and oxidative stress markers as well as volumetric and neurochemical alterations in the mPFC of juvenile SHRs may suggest the cooperation of neurological and immune systems in the ADHD pathogenesis. Elevated levels of steroid hormones in maturating SHRs may be a compensatory effect involved in reducing inflammation and ADHD symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ADHD pathogenesis in the immune, endocrine and nervous systems of juvenile and maturating SHR and WKY rats

et al. 2019

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“…[42][43][44][45] Functional near-infrared spectroscopy, which measures changes in the concentration of oxygenated and deoxygenated haemoglobin, is less sensitive to movement artefacts, which makes it particularly advantageous for the study of individuals with ADHD. In a recent review, 46 most of the studies reported an atypical pattern of oxygenated haemoglobin more prominently in the right hemisphere during the execution of inhibition, attentional control, verbal fluency, facial expression recognition, and affective prosody processing tasks in children with ADHD. Hypoactivation was particularly found in right frontal regions, but also in the temporal and parietal cortices in these children and in bilateral frontal regions in adults.…”

Section: Haemodynamic Measuresmentioning

confidence: 99%

“…Hypoactivation was particularly found in right frontal regions, but also in the temporal and parietal cortices in these children and in bilateral frontal regions in adults. 46…”

Section: Haemodynamic Measuresmentioning

confidence: 99%

Structural and functional neuroimaging in attention‐deficit/hyperactivity disorder

Sáenz

Villemonteix

Massat

2018

Develop Med Child Neuro

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Over the last decade, there has been a dramatic increase in the number of neuroimaging studies in attention‐deficit/hyperactivity disorder (ADHD). In terms of brain structure, magnetic resonance imaging (MRI), and diffusion tensor imaging studies have evidenced differences in volume, surface‐based measures (cortical thickness, surface area, and gyrification), and white matter integrity in different cerebral regions, in children and adults with ADHD compared to population norms. Abnormalities in the basal ganglia, prefrontal structures, and the corpus callosum have been the most consistently reported findings across studies. Hemodynamic (functional MRI, functional near‐infrared spectroscopy, positron emission tomography, single‐photon emission computed tomography) and magnetoencephalography measurements have also shown differences in neural activity during the execution of neuropsychological tasks and during rest, in widespread regions of the brain. Importantly, multimodal studies combining structural and functional methods have shown an intercorrelation between structural and functional abnormalities in ADHD. Further longitudinal studies are needed to clarify the effects of age and medication on brain structure and function in individuals with ADHD. What this paper adds In attention‐deficit/hyperactivity disorder (ADHD), the brain is characterized by abnormal neural network interplay. Structural and functional cerebral abnormalities in ADHD are intercorrelated. Currently there is no neural biomarker that can be used in diagnosis. Longitudinal studies have shed light on the brain correlates of ADHD over the lifespan. The effects of stimulant intake on the brain correlates of ADHD remain unclear.

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“…B. subkortikale Strukturen untersuchen. In einem kurzen Übersichtsartikel hielten die Autoren fest, dass die meisten fNIRS-Studien mit sehr unterschiedlichen Paradigmen ein atypisches Muster von oxygeniertem Hämoglobin vor allem in der rechten Hirnhemisphäre zeigen [64]. Diese Studien zeigten verminderte Aktivität im rechten präfrontalen Kortex, im Gyrus frontalis inferior und medius, aber auch in temporalen und parietalen Cortices.…”

Section: Hämodynamische Bildgebungunclassified

Strukturelle, funktionelle und neurochemische Bildgebung bei der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung

Maier¹,

Nickel²,

Endres³

et al. 2019

Nervenheilkunde

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ZUSAMMENFASSUNGNachdem über 2 Dekaden die Anzahl der Bildgebungsstudien zur Aufmerksamkeitsdefizit/Hyperaktivitätsstörung (ADHS) rasant angestiegen ist, zeichnet sich in den letzten Jahren eine Plateaubildung auf hohem Niveau ab. Das Ziel der meisten dieser Studien war es, die zugrunde liegenden strukturellen und funktionellen Hirnkorrelate bei Patienten mit ADHS zu charakterisieren oder den diagnostischen Nutzen von bildgebungsbasierten Markern zu untersuchen. Während neue Analysemethoden immer tiefere Einsichten in die neuroanatomischen Grundlagen der ADHS erlauben, liegen nach wie vor große Herausforderungen bei der Erforschung der ADHS Hirnanatomie und -funktion in der Heterogenität des Krankheitsbildes sowie unterschiedlich ausgeprägten neuroanatomischen Merkmalen bei Kindern und Erwachsenen mit ADHS. Auch gibt es bezüglich des Zusammenhanges zwischen beobachteten neuroanatomischen Veränderungen und klinischen Symptomen bzw. neuropsychologischen Defiziten bislang wenige gesicherte Erkenntnisse. In diesem Artikel möchten wir die wichtigsten Ergebnisse hirnstruktureller, funktioneller und neurochemischer Bildgebungsstudien bei Kindern und Erwachsenen mit ADHS zusammenfassen und deren Potenzial für die Entwicklung neurobiologischer Marker diskutieren.

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fNIRS Studies on Hemispheric Asymmetry in Atypical Neural Function in Developmental Disorders

Cited by 22 publications

References 66 publications

ADHD pathogenesis in the immune, endocrine and nervous systems of juvenile and maturating SHR and WKY rats

ADHD pathogenesis in the immune, endocrine and nervous systems of juvenile and maturating SHR and WKY rats

Structural and functional neuroimaging in attention‐deficit/hyperactivity disorder

Strukturelle, funktionelle und neurochemische Bildgebung bei der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung

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