Foam fractionation for the concentration of exopolysaccharides produced by repeated batch fermentation of cordyceps militaris

Zheng, Huaili; Hao, Mengmeng; Liu, Wei; Zheng, Wancheng; Yingying,; Fan, Shaoxiong; Wu, Zhaoliang

doi:10.1016/j.seppur.2018.08.063

Cited by 10 publications

(3 citation statements)

References 35 publications

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“…Another study showed that exopolysaccharide (EPS) production of C. militaris could be enhanced to a maximum of 5.713 g/L, with a productivity of 476 mg/L/day in the second run [165]. Moreover, Zheng et al [177] combined repeated-batch fermentation and two-stage foam fractionation to develop a strategy to improve EPS production. The foam system can also promote the EPS separation efficiency during fractionation.…”

Section: Repeated-batch Fermentationmentioning

confidence: 99%

Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production

Chou,

Sung,

Hou

et al. 2024

Applied Sciences

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Cordyceps militaris is a valuable medicinal fungus which has been widely used as a traditional medicine in East Asia. Compared to the well-known medicinal fungus C. sinensis, C. militaris can produce similar fermented metabolites with various biological activities, but it requires a shorter culture time and simpler culture conditions, and therefore, it has attracted increasing attention in recent years. The purpose of this review was to organize the current studies regarding metabolite production from C. militaris relative to their biological functions. We combined findings of metabolite production to correlate with different fermentation modes to obtain a full view of production processes used to yield the product. While research on C. militaris fermentation is not uncommon to date, its high value still highlights the importance of developing more modern fermentation processes for industrial production.

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Section: Repeated-batch Fermentationmentioning

confidence: 99%

Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production

Chou,

Sung,

Hou

et al. 2024

Applied Sciences

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“…9,10 It has been reported that the fermentation broth of O. sinensis has antihyperglycemic activities, moreover, the fermentation broth of Cordyceps has been used to extract polysaccharides and cordycepin. [11][12][13] These indicate that Cordyceps fermentation broth is a valuable culture.…”

Section: Introductionmentioning

confidence: 97%

“…While, liquid fermentation is more efficient for producing mycelia and certain active ingredients compared to solid fermentation, as the long cultivation period of fruiting bodies, typically takes several months, so liquid fermentation mycelia hold a significant share of the market 9,10 . It has been reported that the fermentation broth of O. sinensis has antihyperglycemic activities, moreover, the fermentation broth of Cordyceps has been used to extract polysaccharides and cordycepin 11‐13 . These indicate that Cordyceps fermentation broth is a valuable culture.…”

Section: Introductionmentioning

confidence: 99%

Comparative metabolic profiling of mycelia, fermentation broth, spore powder and fruiting bodies of Ophiocordyceps gracilis by LC–MS/MS

Wang

Yang

Tong

et al. 2023

Phytochemical Analysis

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IntroductionOphiocordyceps gracilis, a type of edible and medicinal fungus, exhibits multiple health‐promoting effects. Due to the scarcity of natural O. gracilis, artificial cultures have been developed as its substitutes. However, lacking comprehension of the metabolite composition of cultures limits its utilisation.ObjectiveThis research aimed to evaluate the nutritional and medicinal value of four cultures of O. gracilis by analysing their metabolite composition. In addition, metabolic pathways in mycelia and fruiting bodies were analysed to explore fruiting body formation mechanism at metabolic level.MethodThe mycelia, fermentation broth, spore powder and fruiting bodies of O. gracilis were cultivated in this study. Their metabolite composition was compared using an untargeted metabolomics approach based on liquid chromatography–tandem mass spectrometry (LC–MS/MS).ResultsPrincipal component analysis (PCA) and orthogonal projections to latent structures discriminant analysis (OPLS‐DA) showed that the four cultures have noticeable differences in metabolite composition. A total of 612 metabolites were identified, among which 159 metabolites showed significant differences, and these differential metabolites were classified into 13 categories. The metabolites in the fruiting bodies were the most abundant compared with other cultures. However, each culture had its own advantages and significantly accumulates some active metabolites respectively. Pearson's correlation analysed the mutual relationship among metabolites. In addition, seven metabolic pathways were closely related to fruiting body formation, such as “Biosynthesis of plant secondary metabolites”, “amino acids metabolism”, “tricarboxylic acid (TCA) cycle”.ConclusionThis study offered a reference to mycelia, fermentation broth, spore powder and fruiting bodies of O. gracilis as health‐promoting functional foods and medicine.

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Fermentation Processes for Production of Fungal Biopolymers with Industrial Applications

Veiga

Piazzi

Mazutti

2022

Fungal Biopolymers and Biocomposites

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Foam fractionation for the concentration of exopolysaccharides produced by repeated batch fermentation of cordyceps militaris

Cited by 10 publications

References 35 publications

Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production

Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production

Comparative metabolic profiling of mycelia, fermentation broth, spore powder and fruiting bodies of Ophiocordyceps gracilis by LC–MS/MS

Fermentation Processes for Production of Fungal Biopolymers with Industrial Applications

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