Purpose Efficacy and safety of ultrasound-guided foam sclerotherapy (UGFS)
for the treatment of primary venous disease is proven, but the main application
field of UGFS remains the treatment of recurrent varicose veins (RVV). The aim
of this study is to determine the extent to which this treatment indication is
evidence-based.
Methods In PubMed and other publicly accessible databases, literature was
reviewed until June 2018 and checked for relevance. The focus was on results
with regard to anatomical success as well as clinical success and perception by
patients.
Results Several observational studies comprised a subgroup of RVV
patients, but systematic stratification for RVV patients were only rarely
performed. In most of these studies including the few reports specifically
investigating RVV patients anatomical success as the primary outcome measure
revealed similar results compared to primary interventions and favourable
results in patients with neovascularization. Data on clinical outcome and
patient perception were inconclusive due to low study numbers and insufficient
stratification. Complications in RVV patients were rare.
Conclusion Although the advantages inherent to the UGFS principle provide
a strong rationale that this method best meets the requirements of the specific
RVV characteristics, concept and previous observations should be supported by
more evidence. Systematic studies in RVV patients with sufficient sample size
are required.