The advantages of optical fiber sensors include their miniaturization, strong anti-interference ability, high sensitivity, low cost, and fast response speed. They can be used for in situ detection in harsh environments, making them suitable for a wide range of applications such as blood detection and monitoring. This technology holds great potential for medical diagnosis and health monitoring, opening up new possibilities in the field. Coating technology plays a crucial role in enhancing the sensitivity and stability of optical fiber sensors, ultimately improving their measurement accuracy and reliability. This manuscript expounds the application status and progression of optical fiber sensors in the determination of blood glucose concentrations, blood pH, diverse proteins in blood, and physical properties of blood. The principle of optical fiber sensors and the application of coating technology for detecting varying targets are scrutinized in detail, with particular emphasis on the advantages and limitations of distinct design schemes. The adept amalgamation of optical fiber sensing technology and coating technology amplifies the adaptability of optical fiber sensors in diverse practical scenarios, thereby presenting novel instruments and methodologies for researchers in pertinent fields to augment their advancement and development.