Focal chorioretinal atrophy in rats.

Abstract

Abstract:Focal chorioretinal atrophy observed in untreated Sprague-Dawley

Nonproliferative and Proliferative Lesions of the Ratand Mouse Special Sense Organs(Ocular [eye and glands], Olfactory and Otic)

“…Conditions resulting in atrophy of the outer retinal layers (outer plexiform and photoreceptor layers) include hereditary or direct photoreceptor injury, and/or RPE toxicity. Atrophy may be incidental following choroidal circular disturbance ( Tanaka, Inagaki et al 1993 ).…”

“…These lighting conditions may occur if animals are kept in cages on the top of racks close to the room light source ( De Vera Mudry, Kronenberg et al 2013 ). In contrast, focal atrophy of outer retinal segments following choroidal circular disturbance is always associated with loss of regional RPE cells ( Tanaka, Inagaki et al 1993 ).…”

Microvasculature of the rat eye: scanning electron microscopy of vascular corrosion casts

“…Some ocular mutations such as retinal and chorioretinal atrophy have been reported in rats. 1 Disturbances in retinal vessel morphology in mutant diabetic and/or hypertensive rats and mice have also been reported. 2,3 A clear understanding of rat eye morphology is necessary and essential for the proper interpretation and evaluation of experimental results obtained with this animal.…”

“…In drug safety assessment, ocular fundus examination is of diagnostic importance in experimental animals such as the rat and mouse. Some ocular mutations such as retinal and chorioretinal atrophy have been reported in rats 1 . Disturbances in retinal vessel morphology in mutant diabetic and/or hypertensive rats and mice have also been reported 2 , 3 .…”