Focal choroidal excavation in Stargardt’s dystrophy

Bhayana, Amber Amar; Azad, Shorya Vardhan; Kumar, Vinod; Neupane, Swechya

doi:10.1136/bcr-2020-237584

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…Several studies that identified choroidal excavation in patients with chorioretinal degeneration did not document significant changes in lesion appearance over time. 5 , 6 , 10 , 19 In contrast, our patient demonstrated progressive FCE deepening in association with choroidal thinning. We suspect that the length of follow-up combined with structured serial SD-OCT imaging facilitated the detection of FCE evolution in our patient ( Fig.…”

Section: Discussionmentioning

confidence: 50%

“…Several occurrences of FCE in the setting of chorioretinal degeneration have been described, including in patients with Best disease, Stargardt disease, pattern dystrophy, and cone dystrophy. 5 , 6 , 7 , 8 They have also been described in patients with choroideremia. 9 The majority of these cases have not depicted significant progression or expansion of the FCE over time; however, many of these reports are of limited follow-up duration.…”

Section: Introductionmentioning

confidence: 95%

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Evolution of focal choroidal excavation in ABCA4-related retinopathy

Benson

Feldman

Zein

2022

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 95%

Evolution of focal choroidal excavation in ABCA4-related retinopathy

Benson

Feldman

Zein

2022

American Journal of Ophthalmology Case Reports

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“…In addition, we found that FCE frequently accompanied CNV: among the 21 eyes with CNV, FCE was present in 14 (66.7%) eyes. FCE has been shown to occur within the area of CNV in eyes with choroidal osteomas and various macular diseases, including typical agerelated macular disease, polypoidal choroidal vasculopathy, central serous chorioretinopathy (CSCR), macular dystrophy, inflammatory diseases, and idiopathic conditions [11,[21][22][23][24][25][26][27][28]. Tumor decalcification leads to outer retinal layer thinning and PR atrophy [29] and may contribute to the development of FCE and CNV in choroidal osteoma cases [28].…”

Section: Discussionmentioning

confidence: 99%

Complications, treatments, and visual prognosis of choroidal osteomas

Seong

Kim

Choi

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose This study aims to report complications, treatments, and visual prognosis of choroidal osteoma. Methods We retrospectively reviewed electronic medical records and multimodal images of 41 patients with choroidal osteoma. Results Visually significant complications included choroidal neovascularization (CNV) in 21 (47.7%) eyes and subretinal fluid (SRF) without CNV in 14 (31.8%) eyes. The most common treatment was intravitreal anti-vascular endothelial growth factor (VEGF) injection: 13 (61.9%) eyes with CNV received an average of 6.3 injections, and 6 (42.9%) eyes with SRF but without CNV received 1.8 injections. As the first-line treatment, intravitreal anti-VEGF injection induced complete or partial remission in 93.4% of eyes with CNV and 57.1% of eyes with SRF. The probability of legally low vision estimated at 3 and at 5 years was 29.1% and 34.2%, respectively. The presence of CNV and outer retinal tubulation (ORT) was independent risk factors for vision loss (adjusted odds ratio, 8.08 and 6.94, respectively). Conclusions The development of CNV and ORT was strong risk factors for visual impairment. Due to the frequent recurrence of complications and poor visual prognosis, regular check-ups and appropriate treatment choices are warranted.

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“…FCE can be pachychoroid-associated and has been reported in cases with CSC, PCV, and isolated thickened choroid [ 62 ]. In addition to pachychoroid, FCE has also been shown to be associated with inflammatory conditions such as multiple evanescent white dot syndrome, multifocal choroiditis and panuveitis, punctate inner choroidopathy and Vogt-Koyanagi-Harada disease; [ 65 – 68 ] and dystrophy conditions such as Stargardt disease, best vitelliform macular dystrophy, and cone dystrophy [ 69 – 72 ].…”

Section: Efficacy Of Photodynamic Therapy In Different Pachychoroid Diseasesmentioning

confidence: 99%

The Contemporary Role of Photodynamic Therapy in the Treatment of Pachychoroid Diseases

Chan

et al. 2021

Journal of Ophthalmology

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Recent advances in retinal imaging technology have improved our understanding in the pathogenesis and evolvement of various chorioretinal diseases. Central serous chorioretinopathy and polypoidal choroidal vasculopathy are now recognized to belong to the same spectrum of disorders known as pachychoroid diseases. Pachychoroid diseases have similar pathogenesis pathway and common characteristics of thickened choroid, dilated outer choroidal vessels, and thinning of choriocapillaris. More disease entities have been identified to belong to this disease spectrum. Photodynamic therapy can induce choroidal hypoperfusion, remodeling of abnormal choroidal vessels, and reduction of choroidal congestion. It is known to be an effective treatment for chronic central serous chorioretinopathy and polypoidal choroidal vasculopathy. Many new studies are being performed to investigate its efficacy in other pachychoroid diseases. In this review, we provided an overview of the rationale, efficacy, and treatment strategies of photodynamic therapy in different pachychoroid diseases and discussed its role in the management along with other treatment modalities with most updated clinical evidence.

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Focal choroidal excavation in Stargardt’s dystrophy

Cited by 5 publications

References 8 publications

Evolution of focal choroidal excavation in ABCA4-related retinopathy

Evolution of focal choroidal excavation in ABCA4-related retinopathy

Complications, treatments, and visual prognosis of choroidal osteomas

The Contemporary Role of Photodynamic Therapy in the Treatment of Pachychoroid Diseases

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