Focal cortical hypermetabolism in atypical benign rolandic epilepsy

Curnow, Sarah R; Vogrin, Simon; Barton, Sarah; Bailey, Catherine; Harvey, A. Simon

doi:10.1016/j.eplepsyres.2020.106288

Cited by 8 publications

(7 citation statements)

References 31 publications

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“…Although the primary goal of antiepileptic treatment is to completely control epileptic seizures, prevention, control, and improvement of cognitive and behavioral dysfunction must be simultaneously considered. Therefore, clinicians must achieve a balance between controlling the epileptic seizures as much as possible and preserving cognitive and behavioral functions[ 10 ]. Long-term outbreaks of spike-and-slow wave rhythm and bilateral asynchronous spike-and-slow wave distribution cause more severe cognitive impairment than single spike waves[ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and electroencephalogram characteristics and treatment outcomes in children with benign epilepsy and centrotemporal spikes

Chen¹,

Li²,

Wen³

et al. 2021

WJCC

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BACKGROUND Epilepsy is a syndrome characterized by transient, rigid, paroxysmal, and repetitive central nervous system dysfunction. Prevention, control, and improvement of cognitive and behavioral dysfunction are of great significance for improving the patients’ intellectual development and quality of life. Electroencephalograms (EEG) can predict an accelerated decline in cognitive function. AIM To determine the clinical and EEG characteristics and treatment results of benign epilepsy in spiking children. METHODS A total of 106 cases of benign epilepsy in children with myocardial spines treated at our hospital from January 2017 to January 2020 were selected. Differences in clinical data and EGG characteristics between treatment-effective/-ineffective patients were analyzed, and children’s intellectual development before and after treatment evaluated using the Gesell Development Diagnostic Scale. RESULTS EEG showed that the discharge proportion in the awake and sleep periods was 66.04%, and the peak/peak discharge was mainly single-sided, accounting for 81.13%, while the discharge generalization accounted for 31.13%. There was no significant difference in any of these variables between sexes and ages ( P > 0.05). The proportion of patients with early onset (< 5 years old) and seizure frequency > 3 times/half a year was 40.00% and 60.00%, respectively; the incidence rate and seizure frequency in the younger age group (< 5 years old) were significantly higher than those in the treatment-effective group ( P < 0.05), while the discharge index was significantly lower than that in the treatment-effective group ( P < 0.05). The discharge index was negatively correlated with fine motor skill and language development ( r = -0.274 and -0.247, respectively; P < 0.05), but not with the rest ( P > 0.05). Logistic regression analysis showed that low age onset (< 5 years old) and seizure frequency were the factors affecting ineffective-treatment of benign epilepsy in children (odds ratio = 11.304 and 5.784, respectively; P < 0.05). The discharge index of the responsive group after treatment was significantly lower than that of the unresponsive group ( P < 0.05). However, there was no significant difference between groups after treatment in gross and fine motor skills, adaptability, language, and personal social development ( P > 0.05). CONCLUSION The EEG of children with benign epilepsy due to spinal wave in central time zone has characteristic changes, and the therapeutic effect is influenced by age of onset and attack frequency.

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Section: Discussionmentioning

confidence: 99%

Clinical and electroencephalogram characteristics and treatment outcomes in children with benign epilepsy and centrotemporal spikes

Chen¹,

Li²,

Wen³

et al. 2021

WJCC

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“…The Chinese version of the Wechsler Intelligence Scale for Children, fourth edition (WISC‐IV) was used to assess the intelligence level of all subjects (WechslerDJTTCBSC, 2007 ) according to a previous research (Yang et al., 2013 ). The scores of this scale are composed of verbal comprehension index (VCI), perceptual reasoning index (Curnow et al., 2020 ) (PRI), working memory index (WMI), processing speed index (PSI), and FSIQ. A previous study revealed a good credibility of this scale (Baron, 2005 ).…”

Section: Methodsmentioning

confidence: 99%

Changes in functional connectivity in newly diagnosed self‐limited epilepsy with centrotemporal spikes and cognitive impairment: An MEG study

Sun

Jiang

et al. 2022

Brain and Behavior

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Purpose: Our purpose was to explore the relationship between cognitive impairment and neural network changes in patients newly diagnosed with self-limited epilepsy with centrotemporal spikes (SeLECTS). Methods:The Wechsler Intelligence Scale for Children, fourth edition was used to divide all SeLECTS patients into two groups: patients with full-scale intelligence quotient (FSIQ) below 80 that corresponded to cognitive impairment, and patients with FSIQ above 80 that corresponded to a normal cognitive function. The data on the resting state were recorded using magnetoencephalography. The properties of the networks were analyzed using graph theory (GT) analysis. Results:The functional connectivity (FC) of the frontal cortex in patients with FSIQ < 80 was reduced in the 12-30 Hz frequency band, and the FC of the posterior cingulate cortex was reduced in the 80-250 and 250-500 Hz frequency bands.The GT analysis showed that patients in the FSIQ < 80 group had higher strength in the 8-12 and 12-30 Hz frequency bands than those in the healthy control and FSIQ > 80 group. However, the path length was reduced in the 80-250 Hz band, and the clustering coefficient was reduced in the 12-30, 80-250, and 250-500 Hz frequency bands. Moreover, the receiver operator characteristic analysis showed that the clustering coefficient in the 12-30 and 80-250 Hz frequency bands, as well as the path length in the 80-250 Hz frequency band possessed a good discriminative ability in distinguishing the FSIQ > 80 group.Conclusions: SeLECTS patients with cognitive impairment in the early stage of the disease developed disordered networks in cognitive-related brain regions. The clustering coefficient in the 12-30 and 80-250 Hz frequency bands as well as the path length in the 80-250 Hz frequency band might be good indicators to distinguish the cognitive impairment of SeLECTS patients at the early stage.

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“…Furthermore, there was no residual neuropsychological damage ( Blom and Heijbel, 1982 ). With advances in neuropsychological testing, as well as the development of brain imaging techniques, more and more scholars have proposed that RE is a non-benign disorder and that some RE patients exhibit atypical symptoms and clinical test results ( Filippini et al, 2015 ; Bektaş et al, 2019 ; Curnow et al, 2020 ). For example, abnormal EEG features, different from typical RE, having repeated failures of conventional antiseizure medications (ASMs) therapy, and poorer neuropsychological cognitive impairment ( Fejerman, 2009 ; Garcia-Ramos et al, 2015 ; He et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Alterations in the default mode network in rolandic epilepsy with mild spike-wave index in non-rapid eye movement sleep

Wang

Jiang

et al. 2022

Front. Neurosci.

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PurposeRolandic epilepsy (RE) is one of the most common epilepsy syndromes during childhood. The aim of this study was to investigate the alterations in the default mode network (DMN) of RE patients whose spike-wave index (SWI) was within the 50–85% range during non-rapid eye movement (NREM) during sleep, as well as to detect early neuroimaging markers.MethodsResting-state data was recorded for each subject using magnetoencephalography (MEG). DMN-related brain regions were chosen as regions of interest. The spectral power and functional connectivity (FC) of the DMN were estimated through the use of minimum norm estimation (MNE) combined with Welch technique and corrected amplitude envelope correlation (AEC-c).ResultsThe patient group included 20 patients with NREM phase 50% ≤ SWI < 85% (mild SWI group), and 18 typical RE patients (SWI < 50% group). At the regional level, the mild SWI group exhibited enhanced spectral power in the delta band of the bilateral posterial cingulate cortex and attenuated the spectral power in the alpha band of the bilateral posterial cingulate cortex. Enhanced spectral power in the bilateral precuneus (PCu) in the delta band and attenuated spectral power in the right lateral temporal cortex (LTC) in the alpha band were common across all RE patients. At the FC level, patients in the mild SWI group indicated increased AEC-c values between the bilateral posterial cingulate cortex in the delta band and between the left medial frontal cortex (MFC) and bilateral posterial cingulate cortex in the alpha band. Increased AEC-c values between the right PCu and left MFC in the delta band, and between the left PCu and right MFC in the theta band, were common across all RE patients. Moreover, the spectral power in the bilateral posterial cingulate cortex in the alpha band and the AEC-c value between the bilateral posterial cingulate cortex in the delta band demonstrated good discrimination ability.ConclusionThe spectral power of the bilateral posterior cingulate cortex (PCC) in the alpha band and the AEC-c value between the bilateral PCC in the delta band may be promising indicators of early differentiation between mild SWI and typical RE.

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Focal cortical hypermetabolism in atypical benign rolandic epilepsy

Cited by 8 publications

References 31 publications

Clinical and electroencephalogram characteristics and treatment outcomes in children with benign epilepsy and centrotemporal spikes

Clinical and electroencephalogram characteristics and treatment outcomes in children with benign epilepsy and centrotemporal spikes

Changes in functional connectivity in newly diagnosed self‐limited epilepsy with centrotemporal spikes and cognitive impairment: An MEG study

Alterations in the default mode network in rolandic epilepsy with mild spike-wave index in non-rapid eye movement sleep

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