Focal Disruptions in Ellipsoid Zone and Interdigitation Zone on Spectral-Domain Optical Coherence Tomography in Pachychoroid Pigment Epitheliopathy

Lee, Jae Hyung; Kim, Jun Yong; Jung, Byung Ju; Lee, Won Ki

doi:10.1097/iae.0000000000002187

Cited by 16 publications

(12 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vision-threatening atrophy or geographic atrophy rarely develops. 27 This study has several limitations. Measurements were performed manually, and at times borders of each layer or points of measurement, particularly under the pachydrusen were difficult to determine.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Choroidal morphology under pachydrusen

Baek

Lee

Chung

et al. 2018

Clinical Exper Ophthalmology

Self Cite

View full text Add to dashboard Cite

Importance To reveal choroidal morphological profiles under pachydrusen. Background Drusen in pachychoroid disorders show certain differences from conventional drusen and are recently named as “pachydrusen.” This study analysed the specific choroidal morphology under pachydrusen. Design This study is a cross‐sectional case series. Participants Enrolled were 136 eyes with pachydrusen from 134 patients. Methods The presence of pachydrusen in fundus area covered by a 12 × 9 mm2 optical coherence tomography (OCT) image was accessed in eyes with pachychoroid‐related diseases or their fellow eyes using colour fundus photography and swept source OCT. Choroidal morphology under the pachydrusen was analysed using OCT B‐scans and en face images. Main Outcome Measures Choroidal thicknesses and topographical correlation between pachydrusen and pachyvessels. Results A total of 225 pachydrusen in 136 eyes were analysed. The mean number of pachydrusen was 1.65 ± 1.07 per eye. Most pachydrusen were located para‐ or perifoveally (37 subfoveal, 86 parafoveal and 102 perifoveal). The proportion of Haller's layer to total choroidal thickness was higher at the area of the pachydrusen compared to the subfovea (0.881 ± 0.081 vs 0.765 ± 0.111, P < 0.001). In multimodal image analysis, 90.1% of pachydrusen identified using fundus photography and OCT B‐scan were located at the area of a dilated Haller vessel (pachyvessel) seen on en face images. Conclusions and Relevance Choroidal morphology under the pachydrusen showed increased Haller's layer thickness with an attenuated choriocapillaris layer, which is the hallmark of pachychoroid definition. Topographically, their locations correlated with the underlying pachyvessel.

show abstract

Section: Discussionmentioning

confidence: 92%

“…Pachydrusen are frequently present as a singular lesion having small extent and distribution of lesion area, and frequently located outside the fovea. Vision‐threatening atrophy or geographic atrophy rarely develops …”

Section: Discussionmentioning

confidence: 99%

Choroidal morphology under pachydrusen

Baek

Lee

Chung

et al. 2018

Clinical Exper Ophthalmology

Self Cite

View full text Add to dashboard Cite

show abstract

“…25,35,51 A small-scale hospital-based study reported that focal RPE atrophy and overlying outer retinal layer changes may be observed after the regression of pachydrusen, but vision-threatening atrophy or GA rarely develops. 52 Taken together, pachydrusen does not seem to affect RPE directly and may have little pathological significance on macular diseases.…”

Section: Discussionmentioning

confidence: 98%

Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population

Sato-Akushichi

Kinouchi

Ishiko

et al. 2021

Ophthalmology Science

View full text Add to dashboard Cite

“…A definitive cut-off point of CT to define CSCR as one of the pachychoroid spectrum disorders is not determined yet. Enhanced Depth Imagine (EDI) OCT significantly shows increased CT in the macula compared to the peripapillary region [22][23][24][25]. Found that the mean subfoveal CT was 450±66µm (range=356-595µm) in eyes with CSCR and 367±86µm (range=220-554µm) in the unaffected fellow eye.…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

“…OCT can be used to identify prognostic biomarkers like intra-retinal hyper-reflective dots, which usually progress from inner to outer retinal layers and correlate with poor visual prognosis. In addition, it can measure the central retinal thickness (CRT), choroidal thickness (CT), and choroidal vascularity index (CVI) [22][23][24][25].…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

Central Serous Chorioretinopathy: A Review of Pathogenesis, Risk Factors, Diagnostic Methods and the Current Treatments

Altıntaş¹

2021

J Opht Res Rev Rep

View full text Add to dashboard Cite

Central serous chorioretinopathy (CSCR) is characterized by serous detachment of the neurosensory layer at the macula. It has a relatively high recurrence rate and mainly affecting middle-aged males. The etiology and pathogenesis of the disease still remain ambiguous. But choroidal changes which increase choroidal vascular permeability are the basic pathology of CSCR. Different diagnostic methods such as FAF, FFA, OCT, OCTA, ICG could be used to detect its biomarkers such as choroidal thickness, choroidal vascularity index, hyperreflective dots for exact diagnosis and treatment response. Acute CSCR generally self-limited, but in recurrent or chronic forms may cause permanent visual loss due to progressive and irreversible damage in the photoreceptor layer of retinal pigment epithelium atrophy. Several treatment alternatives have been reported, such as PDT, intravitreal Anti-VEGF, TTT, Laser, Mineralocorticoid receptor antagonist for chronic and recurrent CSCR.

show abstract

Focal Disruptions in Ellipsoid Zone and Interdigitation Zone on Spectral-Domain Optical Coherence Tomography in Pachychoroid Pigment Epitheliopathy

Abstract: Focal disruptions of the EZ/IZ band can develop in pachychoroid eyes in the absence of subretinal fluid, with a stable clinical course, and possibly as a result of regression of drusenoid lesions. This may represent an atrophic form of pachychoroid manifestation.

Cited by 16 publications

References 34 publications

Choroidal morphology under pachydrusen

Choroidal morphology under pachydrusen

Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population

Central Serous Chorioretinopathy: A Review of Pathogenesis, Risk Factors, Diagnostic Methods and the Current Treatments

Contact Info

Product

Resources

About