Focal eosinophilic myositis with Charcot-Leyden crystal formation

Hamada, Shin; Ueki, Shigeharu; Miyabe, Yui; Tsukino, Mitsuhiro; Hirai, Toyohiro

doi:10.1016/j.alit.2020.03.007

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…Extracellular crystallization of galectin-10 is assumed to occur if eosinophil density and cytolysis are high enough to increase the local concentration of free galectin-10. 8 Under TEM of tissue samples from eosinophilic diseases, CLCs are usually found as electron dense crystals in close proximity to free granules 8 , 17 ( Fig. 7D ).…”

Section: Detection Of Cytolytic Degranulationmentioning

confidence: 99%

“…The pathological contribution of EETosis was made more cogent by recent findings that a classical pathological finding of eosinophilic inflammation, Charcot-Leyden crystal (CLC) formation, is closely associated with EETosis. 8 , 16 , 17 In this review, we describe how to visualize EETosis and EETs in experimental studies using isolated human eosinophils and biopsy tissue samples.…”

Section: Introductionmentioning

confidence: 99%

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How to detect eosinophil ETosis (EETosis) and extracellular traps

Fukuchi

Miyabe

Furutani

et al. 2021

Allergology International

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Section: Detection Of Cytolytic Degranulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

How to detect eosinophil ETosis (EETosis) and extracellular traps

Fukuchi

Miyabe

Furutani

et al. 2021

Allergology International

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“…Morphological analysis (MRI) allowed the confirmation of diagnosis; when performed, this found an isolated mass: T1-weighted images showed a swelling and T2-weighted images an enhanced diffuse reticular pattern of the muscle [6,7,[10][11][12][13].…”

Section: Focal Eosinophilic Myositismentioning

confidence: 99%

“…Table 1. Characteristics of the 69 patients reported in literature with EM: FEM [5][6][7][9][10][11][12][13]19,[51][52][53][54][55];…”

Section: Author Contributionsmentioning

confidence: 99%

Idiopathic eosinophilic myositis: a systematic literature review

Fermon

Authier

Gallay

2022

Neuromuscular Disorders

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Our group has studied hundreds of tissues from patients with allergic or eosinophilic diseases [ 26 29 83 84 155 156 157 158 159 160 ]. In our tissue immunostaining experience, like Gleich et al, we have observed that the extracellular deposition of MBP is not disease-specific, but it is closely associated with tissue damage and the presence of eosinophil cytolysis.…”

Section: “Eosinophilic” Tissue In the Absence Of Eosinophilsmentioning

confidence: 99%

Eosinophil-mediated inflammation in the absence of eosinophilia

Miyabe

Kobayashi

Fukuchi

et al. 2021

Asia Pacific Allergy

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The increase of eosinophil levels is a hallmark of type-2 inflammation. Blood eosinophil counts act as a convenient biomarker for asthma phenotyping and the selection of biologics, and they are even used as a prognostic factor for severe coronavirus disease 2019. However, the circulating eosinophil count does not always reflect tissue eosinophilia and vice versa. The mismatch of blood and tissue eosinophilia can be seen in various clinical settings. For example, blood eosinophil levels in patients with acute eosinophilic pneumonia are often within normal range despite the marked symptoms and increased number of eosinophils in bronchoalveolar lavage fluid. Histological studies using immunostaining for eosinophil granule proteins have revealed the extracellular deposition of granule proteins coincident with pathological conditions, even in the absence of a significant eosinophil infiltrate. The marked deposition of eosinophil granule proteins in tissue is often associated with cytolytic degranulation. Recent studies have indicated that extracellular trap cell death (ETosis) is a major mechanism of cytolysis. Cytolytic ETosis is a total cell degranulation in which cytoplasmic and nuclear contents, including DNA and histones that act as alarmins, are also released. In the present review, eosinophil-mediated inflammation in such mismatch conditions is discussed.

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Focal eosinophilic myositis with Charcot-Leyden crystal formation

Cited by 6 publications

References 8 publications

How to detect eosinophil ETosis (EETosis) and extracellular traps

How to detect eosinophil ETosis (EETosis) and extracellular traps

Idiopathic eosinophilic myositis: a systematic literature review

Eosinophil-mediated inflammation in the absence of eosinophilia

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