Focal epileptiform spikes do not show a canonical BOLD response in patients with benign rolandic epilepsy (BECTS)

Masterton, Richard A. J.; Harvey, A. Simon; Archer, John S.; Lillywhite, Leasha; Abbott, David F.; Scheffer, Ingrid E.; Jackson, Graeme D.

doi:10.1016/j.neuroimage.2010.01.109

Cited by 81 publications

(85 citation statements)

References 47 publications

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“…4 In a previous study using EEG-fMRI, Mastertion and colleague illustrated BOLD responses related to interictal epileptic discharges in the rolandic regions. 60 Therefore, our findings combining structural and functional analysis might delineate the alterations in motor networks related to the epileptic activity in patients with BECT. In addition, the decreased functional connections between the left PCL and regions in the DMN also might reflect abnormalities associated with epileptic activity because the DMN, which linked to the fundamental level of brain function during the resting state, showed remarkable deactivation in response to epileptic spikes and abnormal functional connectivity in patients with epilepsy.…”

Section: Discussionmentioning

confidence: 94%

Altered Structural and Functional Feature of Striato-Cortical Circuit in Benign Epilepsy with Centrotemporal Spikes

Chen

Zhang

Cao

et al. 2015

Int. J. Neur. Syst.

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Benign epilepsy with centrotemporal spikes (BECT) is the most common form of childhood idiopathic focal epilepsy syndrome. We investigated quantitative evidence regarding brain morphology and functional connectivity features to provide insight into the neuroanatomical foundation of this disorder, using high resolution T1-weighted magnetic resonance imaging (MRI) and resting state functional MRI in 21 patients with BECT and in 20 healthy children. The functional connectivity analysis, seeded at the regions with altered gray-matter (GM) volume in voxel-based morphometry (VBM) analysis, was further performed. Then, the observed structural and functional alteration were investigated for their association with the clinical and behavior manifestations. The increased GM volume in the striatum and fronto-temporo-parietal cortex (striato-cortical circuit) was observed in BECT. The decreased connections were found among the motor network and frontostriatal loop, and between the default mode network (DMN) and language regions. Additionally, the GM of striatum was negatively correlated with age at epilepsy onset. The current observations may contribute to the understanding of the altered structural and functional feature of striato-cortical circuit in patients with BECT. The findings also implied alterations of the motor network and DMN, which were associated with the epileptic activity in patients with BECT. This further suggested that the onset of BECT might have enduring structural and functional effects on brain maturation.

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Section: Discussionmentioning

confidence: 94%

Altered Structural and Functional Feature of Striato-Cortical Circuit in Benign Epilepsy with Centrotemporal Spikes

Chen

Zhang

Cao

et al. 2015

Int. J. Neur. Syst.

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“…2007; Masterton et al, 2010;Moeller et al, 2008a,b;van Houdt et al, 2010;Zijlmans et al, 2007) and testing different artifact modeling strategies Liston et al, 2006b;Salek-Haddadi et al, 2006;van Houdt et al, 2010). Comparable efforts were undertaken at the EEG level, also paying special attention to artifacts (Huiskamp, 2005;Siniatchkin et al, 2007a), or the accurate detection and classification of IED Flanagan et al, 2009;Jann et al, 2008;Liston et al, 2006a;Marques et al, 2009;SalekHaddadi et al, 2006;Vulliemoz et al, 2010b;Zijlmans et al, 2007), vigilance effects and ongoing spontaneous 'background' EEG (Moehring et al, 2008;Siniatchkin et al, 2007b;Tyvaert et al, 2008b).…”

Section: Eeg-fmri Applications In Epilepsymentioning

confidence: 99%

A personalized history of EEG–fMRI integration

Laufs

2012

NeuroImage

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“…IED-related multifocal positive and negative haemodynamic changes have been commonly revealed both distant and local to the presumed epileptic focus Salek-Haddadi, Diehl et al 2006). These findings have raised questions about the behaviour of the networks associated with epileptiform discharges, and in particular how haemodynamic responses are coupled to these events (Logothetis 2008) as the neurovascular coupling could be altered in pathological states such as epilepsy (Hamandi, Laufs et al 2008;Lemieux, Laufs et al 2008;Grouiller, Vercueil et al 2010;Masterton, Harvey et al 2010). Moreover, scalp EEG-fMRI fails to reveal convincing haemodynamic changes in a significant proportion of cases, possibly due to the limited sensitivity of scalp EEG and consequent poor characterisation of the baseline and inefficient modelling of the fMRI signal (Al-Asmi, Benar et al 2003;Salek-Haddadi, Diehl et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous intracranial EEG and fMRI of interictal epileptic discharges in humans

et al. 2011

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Simultaneous scalp EEG-fMRI measurements allow the study of epileptic networks and more generally, of the coupling between neuronal activity and haemodynamic changes in the brain. Intracranial EEG (icEEG) has greater sensitivity and spatial specificity than scalp EEG but limited spatial sampling. We performed simultaneous icEEG and functional MRI recordings in epileptic patients to study the haemodynamic correlates of intracranial Interictal Epileptic Discharges (IED).Two patients undergoing icEEG with subdural and depth electrodes as part of the presurgical assessment of their pharmaco-resistant epilepsy participated in the study.They were scanned on a 1.5T MR scanner following a strict safety protocol.Simultaneous recordings of fMRI and icEEG were obtained at rest. IED were subsequently visually identified on icEEG and their fMRI correlates were mapped using a General Linear Model (GLM).On scalp EEG-fMRI recordings performed prior to the implantation, no IED were detected. icEEG-fMRI was well tolerated and no adverse health effect was observed. intra-MR icEEG was comparable to that obtained outside the scanner. In both cases, significant haemodynamic changes were revealed in relation to IED, both close to the most active electrode contacts and at distant sites. In one case, results showed an epileptic network including regions that could not be sampled by icEEG, in agreement with findings from magneto-encephalography, offering some explanation for the persistence of seizures after surgery.Hence, icEEG-fMRI allows the study of whole-brain human epileptic networks with unprecedented sensitivity and specificity. This could help improve our understanding of epileptic networks with possible implications for epilepsy surgery.4

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Focal epileptiform spikes do not show a canonical BOLD response in patients with benign rolandic epilepsy (BECTS)

Cited by 81 publications

References 47 publications

Altered Structural and Functional Feature of Striato-Cortical Circuit in Benign Epilepsy with Centrotemporal Spikes

Altered Structural and Functional Feature of Striato-Cortical Circuit in Benign Epilepsy with Centrotemporal Spikes

A personalized history of EEG–fMRI integration

Simultaneous intracranial EEG and fMRI of interictal epileptic discharges in humans

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