Focal fat deposition in axial bone marrow: MR characteristics.

Hájek, P.; Baker, L L; Goobar, Julio E.; Sartoris, D J; Hesselink, John R.; Haghighi, Parviz; Resnick, D

doi:10.1148/radiology.162.1.3786770

Cited by 92 publications

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“…Radiologic features of the bone marrow of the patients showed more heterogeneous and patchy distribution of the signal intensity compared to that of the referents. This is compatible with a report that regeneration of the hematopoietic cells in bone marrow expands from islands of regenerative centers 18,19) . Distribution of the signal indices among the referents showed a characteristic pattern simulating the curvature of thoracolumbosacral spine, i.e., high at lower thoracic spine, lowering as it comes along the lumbar spine, lowest at L4, then gets higher up to sacrum, highest at S1.…”

Section: Discussionsupporting

confidence: 93%

Quantitative Assessment of Bone Marrow Cellularity by Magnetic Resonance Imaging in Workers with Long-Term Exposure to Solvents.

et al. 2004

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This study was conducted to develop a noninvasive method of bone marrow cellularity evaluation in solvent-exposed painters. Six painters with hypocellular marrow and 132 referents were examined using magnetic resonance imaging (MRI). Full examination of the peripheral blood and bone marrow biopsy was done on each patient. Signal indices were calculated from the signal intensities measured at the vertebral bodies from T12 to S1 and on the paraspinal muscles on both the T1-and the T2-weighted image (T1WI and T2WI). Bone marrow cellularities of the painters were between 20.3% and 33.6%. Signal indices at T1WI were greater in the hypocellular marrow cases compared to those of the referents (p<0.05, p<0.01) and were significantly higher in older women compared with men (p<0.05). After adjusting for age and gender, the signal index of cases at S1 of T1WI was higher than that of the referents by 0.364. Five of the six cases had signal index at S1 of T1WI higher than the mean + 1 standard deviation for the same age group and gender. MRI signal indices can be used as a useful indicator of bone marrow cellularity in a high-risk population after adequate adjustment.

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Section: Discussionsupporting

confidence: 93%

Quantitative Assessment of Bone Marrow Cellularity by Magnetic Resonance Imaging in Workers with Long-Term Exposure to Solvents.

et al. 2004

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“…Marrow changes occurring in L5 pedicles have been reported. Hajek et al [8] and de Roos et al [3] first noted MR signal changes of vertebral body end plates in response to degenerative disc disease. Modic et al [14,15] concluded that pathological changes such as the extent of vertebral body sclerosis correlate well with MR signal intensity changes in vertebrae.…”

Section: Discussionmentioning

confidence: 99%

L5 Pedicle Length Is Increased in Subjects With Spondylolysis: An Anatomic Study of 1072 Cadavers

Bajwa

Toy

Ahn

2012

Clinical Orthopaedics &Amp; Related Research

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Background In spondylolisthesis, it is believed that as L5 slips on S1, the pedicle may become elongated in response to the instability in an attempt to bridge the defect. Whether patients with spondylolysis, which is largely developmental, also develop elongation of the pedicles is unknown. Questions/purposes The purpose of this study is to evaluate and quantify the increase in L5 pedicle length in subjects with spondylolysis as compared with normal healthy subjects. Methods Nine hundred fifty-two human cadaveric specimens without spondylolysis and 120 specimens with spondylolysis from the Hamann-Todd Osteological Collection were examined by a single examiner. Baseline data, including age, sex, and race of specimens, were collected. Digital calipers were used to measure the pedicle lengths at the L5 level. Linear regression analysis was performed to compare the L5 pedicle lengths in healthy patients and patients with spondylolysis. Results Linear regression showed a significant association of increased L5 pedicle length in subjects with spondylolysis. The average L5 pedicle length in subjects with spondylolysis was greater compared with subjects without spondylolysis. In spondylolytic specimens, pedicles start to elongate after the age of 40 years. The pedicle lengths increase progressively from 5.6 mm at 40 years to 6.7 mm at 80 years with a 1% to 3% increment every decade. The pedicle lengths showed little variation in specimens from healthy subjects. Conclusions In spondylolytic specimens, there is progressive elongation of L5 pedicle length after the third decade. An increase in L5 pedicle length in all age groups compared with the specimens from healthy subjects suggests that pathologic changes occur in bony anatomy of L5 vertebrae as early as adolescence when the condition develops.

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“…At birth, skeletal marrow consists entirely of hematopoietic tissue [2,7,9,11]. However, a progressive conversion to fatty (yellow) marrow occurs with age, beginning in the peripheral skeleton.…”

Section: Discussionmentioning

confidence: 99%

“…However, a progressive conversion to fatty (yellow) marrow occurs with age, beginning in the peripheral skeleton. This dynamic process is affected by biological aging, sex, and the amount of stress placed upon an individual bone [2,5,7]. A normal adult distribution is present after the age of 25 years, the red marrow being retained in the membranous bones, ribs, sternum and proximal long bones [9,11].…”

Section: Discussionmentioning

confidence: 99%

Negative scintigraphy with positive magnetic resonance imaging in bone metastases

et al. 1990

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We report three patients with known primary tumor in whom radionuclide skeletal imaging for metastatic disease was normal with or without clinical symptomatology referable to this area. Magnetic resonance imaging (MRI) of the spine demonstrated focal areas of abnormal signal intensity in the vertebral bodies of these patients. In all three patients, biopsy confirmed metastatic disease. All the patients received radiation or chemotherapy depending upon the etiology. These preliminary data suggest that MR imaging may be useful in evaluating patients with known primary tumor in whom clinical suspicion persists despite a negative radionuclide bone scan.

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Focal fat deposition in axial bone marrow: MR characteristics.

Cited by 92 publications

References 0 publications

Quantitative Assessment of Bone Marrow Cellularity by Magnetic Resonance Imaging in Workers with Long-Term Exposure to Solvents.

Quantitative Assessment of Bone Marrow Cellularity by Magnetic Resonance Imaging in Workers with Long-Term Exposure to Solvents.

L5 Pedicle Length Is Increased in Subjects With Spondylolysis: An Anatomic Study of 1072 Cadavers

Negative scintigraphy with positive magnetic resonance imaging in bone metastases

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