Focal gradual-onset variant of stiff-person syndrome

Froiz, I. Payo; Moll, Christian; Reig, Josep Casadellà; Martin, Maik; Ibáñez, A. Espino

doi:10.1016/j.nrleng.2014.10.015

Cited by 1 publication

(1 citation statement)

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“…Some rarer disorders can present with clinical manifestations similar to PNH syndromes, and clinicians often must pose differential diagnoses: episodic ataxia type 1, presenting with myokymia and generalized ataxia; Schwartz-Jampel syndrome, characterized by skeletal deformities, facial dysmorphism, and myotonia; rippling muscle syndrome, in which muscle percussion provokes rolling movements; and Stiff-person syndrome, in which prolonged muscle contractions lead to generalized stiffness [214][215][216][217][218][219][220][221][222][223][224].…”

Section: Classification Of Pnh Syndromesmentioning

confidence: 99%

Paraneoplastic Cerebellar Degeneration Associated with Breast Cancer: A Case Report and a Narrative Review

Norrito,

Puleo,

Pintus

et al. 2024

Brain Sciences

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Paraneoplastic neurological syndromes (PNSs) are an uncommon complication of cancer, affecting nearby 1/10,000 subjects with a tumour. PNSs can involve all the central and peripheral nervous systems, the muscular system, and the neuromuscular junction, causing extremely variable symptomatology. The diagnosis of the paraneoplastic disease usually precedes the clinical manifestations of cancer, making an immediate recognition of the pathology crucial to obtain a better prognosis. PNSs are autoimmune diseases caused by the expression of common antigens by the tumour and the nervous system. Specific antibodies can help clinicians diagnose them, but unfortunately, they are not always detectable. Immunosuppressive therapy and the treatment of cancer are the cornerstones of therapy for PNSs. This paper reports a case of PNSs associated with breast tumours and focuses on the most common paraneoplastic neurological syndromes. We report a case of a young female with a clinical syndrome of the occurrence of rigidity in the right lower limb with postural instability with walking supported and diplopia, with a final diagnosis of paraneoplastic cerebellar degeneration and seronegative rigid human syndrome associated with infiltrating ductal carcinoma of the breast.

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