Focal infection: new age or ancient history?

Infections associated with orthopedic implants

“…In a cohort study of 40 consecutive episodes of prosthetic knee associated infection, the fraction of hematogenous infections has been estimated at 38% [28]. Since the risk of a bacteremia from periodontitis, oral hygiene and mastication is considerably higher than from dental treatment, the routine use of antibiotic prophylaxis during procedures with potential bacteremia is not recommended [29]. Good oral hygiene with regular removal of dental plaque may also reduce incidence of bacteremia.…”

Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?

“…An unprecedented surge in dental extractions ensued over several decades. [2][3][4][5][6] By the mid-20th century, lack of supporting scientific evidence tempered the focus on oral disease as a cause of systemic illness. That focus was revived Ϸ20 years ago after reports of a potential connection between chronic periodontal diseases (PDs) and atherosclerotic vascular disease (ASVD).…”

Is Bacteriolysis In vivo a Friend or a Foe? Relation to Sepsis, Chronic Granulomatous Inflammation and to Oral Disorders: an Overview Hypothesis

“…At this point, it should also bring us back to the late eighteen nineties and early nineteen twenties, when the hotly-debated "focus of infection theory" and its relation to oral and systemic manifestations, had been proposed [60][61][62][63][64][65][66]. Accordingly, oral microorganisms, involving no less than 500 species, but mainly cariogenic streptococci, staphylococci, strict anaerobes causing periodontal disease, and fungal cells may lodge in injured heart valves (endocarditis), traumatized joints (arthritis) and in additional damaged tissue sites [37,38,[62][63][64][65][66].…”