“…In a study of 70 cases of myelofibrosis, extramedullary hematopoiesis was almost always seen in the spleen microscopically [7]. Splenomegaly is usually the leading clinical finding, but some degree of myeloid metaplasia is always present in the liver if the spleen is involved [1]. Other less frequent sites of involvement include lymph nodes, adrenal gland, cranial vault, retroperitoneum, breast, spinal canal, renal pelvis, thymus, heart, lung, pleura, skin, dura mater, and epididymis [1,5,7,8].…”