Focal iron sparing and focal fat sparing of liver in patients with hemosiderosis: diagnosis by combination of r2* relaxometry and fat fraction calculation by mri.

Karçaaltıncaba, Muşturay; İdilman, İlkay S.; Çelik, Azim

doi:10.4261/1305-3825.dir.4134-10.1

Cited by 10 publications

(6 citation statements)

References 17 publications

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“…The iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation (IDEAL IQ) sequence is a new MR fat quantification method that is based on the IDEAL method (11) and that has been used to estimate the fat fraction (FF) within many organs. DCE MR imaging and the IDEAL IQ sequence have shown great potential for use in the assessment of vascular permeability and fat quantification (6,(11)(12)(13).…”

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confidence: 99%

Quantitative Evaluation of Vertebral Microvascular Permeability and Fat Fraction in Alloxan-induced Diabetic Rabbits

Zha

Wang

et al. 2018

Radiology

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Purpose To determine longitudinal relationships between lumbar vertebral bone marrow permeability and marrow adipose tissue in a rabbit diabetes model by using quantitative dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging and iterative decomposition of water and fat with the echo asymmetry and least-squares estimation quantitation (IDEAL IQ) sequence. Materials and Methods Twenty rabbits were randomly assigned to the diabetic (n = 10) or control (n = 10) group. All rabbits underwent sagittal MR imaging of the lumbar region at fixed time points (0, 4, 8, 12, and 16 weeks after alloxan injection). A linear mixed-effects model was used to analyze fat fraction (FF) and permeability parameter changes for 16 months after baseline. These parameters were compared between the two groups by using an independent-samples t test. Correlation of DCE MR imaging parameters with FF and with microvessel density (MVD) was analyzed by using the Spearman correlation coefficient. All statistical analyses were performed with software. Results Twelve weeks after injection, transfer constant (K) and rate constant (K) were markedly and significantly increased, while fractional plasma volume (V) significantly decreased. The volume of extravascular extracellular space (V) decreased significantly after 16 weeks in the diabetic group. MVD was negatively correlated with K and K and positively correlated with V and V, while FF was positively correlated with K and K and negatively correlated with V and V (P < .05 for all). Conclusion DCE MR imaging and the IDEAL IQ sequence can be used for quantitative evaluation of changes in vertebral microvascular permeability and vertebral fat deposition in alloxan-induced diabetic rabbits. This variation is highly associated with increased vertebral fat deposition. RSNA, 2017 Online supplemental material is available for this article.

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confidence: 99%

Quantitative Evaluation of Vertebral Microvascular Permeability and Fat Fraction in Alloxan-induced Diabetic Rabbits

Zha

Wang

et al. 2018

Radiology

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“…The motion-resolved reconstruction provides serial images reconstructed across different motion states, which may have clinical benefits, especially in patients with heterogeneous iron deposition, where focal iron sparing near the liver dome may mimic a lesion and its improved delineation may avert further imaging or invasive biopsy. 47,48 For 4 human subjects (2 healthy volunteers and 2 patients with liver iron overload), ROI-based mean ± SD was measured for each motion state in R * 2 and susceptibility maps as shown in Figure S4. Due to the volumetric change of the liver during respiration, we placed the ROIs in such a way that their positions are progressively translated along the SI direction depending on the liver motion from end-expiration to end-inspiration.…”

Section: Discussionmentioning

confidence: 99%

“…The soft‐gating and motion‐resolved reconstructions presented similar image quality with no major difference, yet the motion‐resolved reconstruction showed a slightly better delineation of the liver dome, indicating improved motion robustness. The motion‐resolved reconstruction provides serial images reconstructed across different motion states, which may have clinical benefits, especially in patients with heterogeneous iron deposition, where focal iron sparing near the liver dome may mimic a lesion and its improved delineation may avert further imaging or invasive biopsy 47,48 . For 4 human subjects (2 healthy volunteers and 2 patients with liver iron overload), ROI‐based mean ± SD was measured for each motion state in

{\mathrm{R}}_2^{\ast }

and susceptibility maps as shown in Figure S4.…”

Section: Discussionmentioning

confidence: 99%

Free‐breathing high isotropic resolution quantitative susceptibility mapping (QSM) of liver using 3D multi‐echo UTE cones acquisition and respiratory motion‐resolved image reconstruction

Kang

Behr

Jafari

et al. 2023

Magnetic Resonance in Med

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PurposeTo enable free‐breathing and high isotropic resolution liver quantitative susceptibility mapping (QSM) using 3D multi‐echo UTE cones acquisition and respiratory motion‐resolved image reconstruction.MethodsUsing 3D multi‐echo UTE cones MRI, a respiratory motion was estimated from the k‐space center of the imaging data. After sorting the k‐space data with estimated motion, respiratory motion state‐resolved reconstruction was performed for multi‐echo data followed by nonlinear least‐squares fitting for proton density fat fraction (PDFF), , and fat‐corrected B0 field maps. PDFF and B0 field maps were subsequently used for QSM reconstruction. The proposed method was compared with motion‐averaged (gridding) reconstruction and conventional 3D multi‐echo Cartesian MRI in moving gadolinium phantom and in vivo studies. Region of interest (ROI)‐based linear regression analysis was performed on these methods to investigate correlations between gadolinium concentration and QSM in the phantom study and between and QSM in in vivo study.ResultsCones with motion‐resolved reconstruction showed sharper image quality compared to motion‐averaged reconstruction with a substantial reduction of motion artifacts in both moving phantom and in vivo studies. For ROI‐based linear regression analysis of the phantom study, susceptibility values from cones with motion‐resolved reconstruction ( = 0.31 0.05, = 0.999) and Cartesian without motion ( = 0.32 0.04, = 1.000) showed linear relationships with gadolinium concentrations and showed good agreement with each other. For in vivo, motion‐resolved reconstruction showed higher goodness of fit ( = 0.00261 0.524, = 0.977) compared to motion‐averaged reconstruction ( = 0.0021 0.572, = 0.723) in ROI‐based linear regression analysis between and QSM.ConclusionFeasibility of free‐breathing liver QSM was demonstrated with motion‐resolved 3D multi‐echo UTE cones MRI, achieving high isotropic resolution currently unachievable in conventional Cartesian MRI.

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“…IDEAL, the ancestor of IDEAL IQ, was shown in an experimental model using ob/ob NAFLD mice not to be influenced by liver iron overload induced experimentally by injection of supermagnetic iron oxide (SPIO) [28], whereas SPIO infused in 14 patients with liver disease and investigated with IDEAL IQ significantly increased R2* in liver (and spine) without modifying hepatic (and spine) PDFF [29]. IDEAL IQ has been shown to correctly analyze liver steatosis in iron overload patients of various etiologies in Taiwan [30], and to correctly diagnose focal sparing of iron and fat in iron overloaded liver of thalassemia and haematologic diseases [31]. Conversely, extensive patchy artifacts on PDFF maps have recently been described in heavily iron overloaded thalassemic patients in Turkey, with liver R2* > 670 Hz/liver T2* < 1.5 ms studied by IDEAL IQ together with artifactual high MRI-PDFF values in these patchy areas [32].…”

Section: Discussionmentioning

confidence: 99%

Liver Iron Load Influences Hepatic Fat Fraction in End-Stage Renal Disease Patients on Dialysis: A Proof of Concept Study

et al. 2019

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BackgroundNonalcoholic fatty liver disease (NAFLD) is a spectrum of diseases including steatosis, nonalcoholic steatohepatitis (NASH), cirrhosis, and end-stage liver failure. Hepatic iron accumulation has been linked to hepatic fibrosis severity in NASH and NAFLD. Iron overload induced by parenteral (IV) iron therapy is a potential clinical problem in dialysis patients. We analyzed the hypothetical triggering and aggravating role of iron on NAFLD in patients on dialysis.MethodsLiver iron concentration (LIC) and hepatic proton density fat fraction (PDFF) were analyzed prospectively in 68 dialysis patients by magnetic resonance imaging (MRI). Follow up of LIC and PDFF was performed in 17 dialysis patients during iron therapy.FindingsPDFF differed significantly among dialysis patients classified according to LIC: patients with moderate or severe iron overload had increased fat fraction (PDFF: 7.9% (0.5–14.8%)) when compared to those with normal LIC (PDFF: 5% (0.27–11%)) or mild iron overload (PDFF: 5% (0.30–11.6%); P = 0.0049). PDFF correlated with LIC, and ferritin and body mass index. In seven patients monitored during IV iron therapy, LIC and PDFF increased concomitantly (PDFF: initial 2.5%, final 8%, P = 0.0156; LIC: initial 20 μmol/g, final 160 μmol/g: P = 0.0156), whereas in ten patients with iron overload, PDFF decreased after IV iron withdrawal or major dose reduction (initial: 8%, final: 4%; P = 0.0098) in parallel with LIC (initial: 195 μmol/g, final: 45 μmol/g; P = 0.002).InterpretationLiver iron load influences hepatic fat fraction in dialysis patients. Iron overload induced by iron therapy may aggravate or trigger NAFLD in dialysis patients.Trial registration number (ISRCTN)80100088.

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Focal iron sparing and focal fat sparing of liver in patients with hemosiderosis: diagnosis by combination of r2* relaxometry and fat fraction calculation by mri.

Cited by 10 publications

References 17 publications

Quantitative Evaluation of Vertebral Microvascular Permeability and Fat Fraction in Alloxan-induced Diabetic Rabbits

Quantitative Evaluation of Vertebral Microvascular Permeability and Fat Fraction in Alloxan-induced Diabetic Rabbits

Free‐breathing high isotropic resolution quantitative susceptibility mapping (QSM) of liver using 3D multi‐echo UTE cones acquisition and respiratory motion‐resolved image reconstruction

Liver Iron Load Influences Hepatic Fat Fraction in End-Stage Renal Disease Patients on Dialysis: A Proof of Concept Study

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