Focal nodular hyperplasia associated with a giant hepatocellular adenoma: A case report and review of literature

Gaspar-Figueiredo, Sérgio; Kefleyesus, Amaniel; Sempoux, Christine; Uldry, Émilie; Halkic, Nermin

doi:10.4254/wjh.v13.i10.1450

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…It is worth mentioning that the co-occurrence of FNH and hepatocellular adenomas or carcinomas has been described in the literature [ 70 , 71 , 72 , 73 , 74 ]. Despite FNH being a rare condition, Langrehr et al [ 71 ] suggested that a high index of suspicion and awareness should be maintained for rapidly growing FNH lesions, considering there are a few patients with hepatocellular carcinomas associated with FNH.…”

Section: Pathogenesis Molecular Features and Associated Diseasesmentioning

confidence: 99%

Pedunculated Focal Nodular Hyperplasia: When in Doubt, Should We Cut It Out?

Tsalikidis,

Mitsala,

Pappas-Gogos

et al. 2023

JCM

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Focal nodular hyperplasia (FNH) is the second most common benign hepatic tumor and can rarely present as an exophytic solitary mass attached to the liver by a stalk. Most FNH cases are usually detected as incidental findings during surgery, imaging or physical examination and have a high female predominance. However, the pedunculated forms of FNH are particularly rare and commonly associated with severe complications and diagnostic challenges. Hence, our study aims to provide a comprehensive summary of the available data on the pedunculated FNH cases among adults and children. Furthermore, we will highlight the role of different therapeutic options in treating this clinical entity. The use of imaging techniques is considered a significant addition to the diagnostic toolbox. Regarding the optimal treatment strategy, the main indications for surgery were the presence of symptoms, diagnostic uncertainty and increased risk of complications, based on the current literature. Herein, we also propose a management algorithm for patients with suspected FNH lesions. Therefore, a high index of suspicion and awareness of this pathology and its life-threatening complications, as an uncommon etiology of acute abdomen, is of utmost importance in order to achieve better clinical outcomes.

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Section: Pathogenesis Molecular Features and Associated Diseasesmentioning

confidence: 99%

Pedunculated Focal Nodular Hyperplasia: When in Doubt, Should We Cut It Out?

Tsalikidis,

Mitsala,

Pappas-Gogos

et al. 2023

JCM

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Patient with a novel syndrome with multiple benign hepatic lesions and extrahepatic neoplasms

Wilken,

Thevathasan,

Kamali

et al. 2023

Clin J Gastroenterol

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Simultaneous occurrence of benign hepatic lesions of different types is a sporadic phenomenon. To the best of our knowledge, we report the first clinical case of a syndrome with simultaneous manifestations of three different entities of benign liver tumors (hepatocellular adenoma, focal nodular hyperplasia and hemangioma) with a novel mutation detected in the liver adenoma and in the presence of a number of further extrahepatic organ neoplasms. Furthermore, we describe for the first time the presence of liver epithelial cells of hepatocytic phenotype expressing cytokeratin 7 (CK7) at the border of the adenoma. These findings may be important for explaining pathogenesis of benign as well as malignant tumors based on genetic and histopathological features.

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Focal nodular hyperplasia associated with a giant hepatocellular adenoma: A case report and review of literature

Cited by 2 publications

References 31 publications

Pedunculated Focal Nodular Hyperplasia: When in Doubt, Should We Cut It Out?

Pedunculated Focal Nodular Hyperplasia: When in Doubt, Should We Cut It Out?

Patient with a novel syndrome with multiple benign hepatic lesions and extrahepatic neoplasms

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