Focal Nodular Hyperplasia in Children Following Treatment of Hemato-Oncologic Diseases

Freidl, T.; Lackner, Helmut; Huber, Johannes; Sovinz, Petra; Moser, Austin; Schroettner, B.; Schwinger, Wolfgang; Úrban, Cícero

doi:10.1055/s-0028-1083807

Cited by 16 publications

(5 citation statements)

References 7 publications

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“…Benign hepatic lesions are rare entities in childhood but some of them have been reported more frequently in children with a history of malignancy after cancer treatment (1,2). An increased prevalence of focal nodular hyperplasia (FNH) has been reported in children after chemoradiation therapy (1)(2)(3)(4) especially after hematopoietic stem cell transplantation (HSCT) (5)(6)(7). Nodular regenerative hyperplasia (NRH) has also been reported as a rare sequela of antineoplastic therapy (8)(9)(10)(11).…”

mentioning

confidence: 99%

Benign Hepatic Nodular Lesions After Treatment for Childhood Cancer

Masetti¹,

Colecchia²,

Rondelli³

et al. 2013

J. pediatr. gastroenterol. nutr.

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confidence: 99%

Benign Hepatic Nodular Lesions After Treatment for Childhood Cancer

Masetti¹,

Colecchia²,

Rondelli³

et al. 2013

J. pediatr. gastroenterol. nutr.

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“…In the general pediatric population, an annual incidence of FNH of 0.02% has been estimated and a significant percentage of the pediatric cases are described in children with a history of malignant disease treated with chemo‐radiation therapy or in children given HSCT . The use of high‐dose alkylating agents during a myeloablative conditioning regimen and complications targeting endothelial cells, such as GVHD, SOS, and thrombotic microangiopathy together with other variables linked to the HSCT procedure can represent risk factors for the development of FNH in the pediatric age .…”

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confidence: 99%

Focal nodular hyperplasia of the liver in children after hematopoietic stem cell transplantation

Masetti

Zama

Gasperini

et al. 2013

Pediatric Transplantation

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FNH is a non-malignant neoplasia of the liver rarely described in children. A significant percentage of the pediatric cases have been reported in patients with a history of malignant disease treated with chemo-radiation therapy and in children who were given HSCT. Little is known about the pathogenesis of FNH in transplanted children, but many risk factors linked to the HSCT procedure have been hypothesized. The detection of hepatic nodules, particularly in children who underwent HSCT for a previous malignancy, always raises a diagnostic dilemma. To help the physicians in the diagnostic management of this rare entity, we have retrospectively evaluated a series of transplanted children diagnosed with FNH in our Center over the last 15 yr. In this period, we found 10 new diagnoses of FNH. The diagnostic work-up included CEUS, abdominal CT, and MRI. A liver biopsy was performed in two patients. The median FUP time after diagnosing FNH was 3.8 yr, with an abdominal US and no malignant transformation were observed. Possible risk factors and indications for the management of FNH in transplanted children are reported and discussed in a comprehensive review of the literature.

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“…FNH is an uncommon occurrence in the pediatric population, accounting for 2% of all hepatic tumors and 5% of all FNHs 18. Several associations have been made with FNH in this population, including stem cell transplantion19 and chemotherapeutic and radiation treatment of hemato‐oncological disease 13, 20, 21. The aforementioned treatments and/or associated diseases are likely contributing to altered hepatic vascular perfusion, predisposing patients to the formation of FNH.…”

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confidence: 99%

Abdominal compression: A new intraoperative maneuver to detect chyle fistulas during left neck dissections that include level IV

et al. 2012

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To our knowledge, this is the first description of a specific maneuver to actively detect a lymphatic fistula at the end of a left neck dissection involving level IV. In this study, intraoperative abdominal compression was able to detect an open lymphatic vessel in 6.3% of the cases, as well as to assure its effective sealing in the remaining 93.7% of the patients. Moreover, no life-threatening high-volume fistula was noted in this study.

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Focal Nodular Hyperplasia in Children Following Treatment of Hemato-Oncologic Diseases

Abstract: Diagnosis of FNH has to be included in the differential diagnosis of uncertain liver lesions. Biopsy might be avoided by using special imaging techniques like MRI, CT and ultrasound. A wait and see strategy is recommended, specific treatment is not necessary.

Cited by 16 publications

References 7 publications

Benign Hepatic Nodular Lesions After Treatment for Childhood Cancer

Benign Hepatic Nodular Lesions After Treatment for Childhood Cancer

Focal nodular hyperplasia of the liver in children after hematopoietic stem cell transplantation

Abdominal compression: A new intraoperative maneuver to detect chyle fistulas during left neck dissections that include level IV

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