Focal nodular hyperplasia-like lesions in patients with cavernous transformation of the portal vein: prevalence, MR findings and natural history

Marin, Daniele; Galluzzo, Anna; Plessier, Aurélie; Brancatelli, Giuseppe; Valla, Dominique; Vilgrain, Valérie

doi:10.1007/s00330-011-2161-z

Cited by 49 publications

(43 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In their series, only one fatcontaining HCA was detected on pathology. (2) In the present case, an association of FNH, multiacinar regenerative nodules, and HNF1A mutated HCC was demonstrated. During follow-up, the progression and malignant transformation into HCC HNF1A inactivated was demonstrated.…”

Section: Discussionsupporting

confidence: 56%

“…CTPV markedly alters hepatic vascular hemodynamics and may result in growth of hypervascular regenerative nodules. Marin et al observed so‐called FNH‐like lesions in 12 of 58 patients (21%) with CTPV . They postulated that these so‐called FNH‐like lesions represent a regenerative hyperplasia of the hepatic parenchyma in response to increased arterial perfusion in areas with decreased portal blood flow.…”

Section: Discussionmentioning

confidence: 61%

See 1 more Smart Citation

Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis

Arrivé¹,

Zucman‐Rossi

Balladur³

et al. 2016

Hepatology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 61%

Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis

Arrivé¹,

Zucman‐Rossi

Balladur³

et al. 2016

Hepatology

View full text Add to dashboard Cite

“…[6][7][8] They have been described in Budd-Chiari syndrome and other vascular liver disorders. 2,9,10 An increased incidence in long time cancer survivors previously treated by chemo or radiotherapy, especially paediatric patients, has also been described, and the mechanism seems to be related to the non-selective effect of chemotherapy regimens in the non-tumorous liver. [11][12][13] Particularly, the use of oxaliplatin-based compounds has been associated with such FNH-like lesions.…”

Section: Introductionmentioning

confidence: 99%

“…18 Other differences have been reported, such as T1 hyperintensity and T2 hypointensity of MRN lesions, absence of the central scar or a hypodense/intense rim. 2,9,17,19 Furthermore, MRN should be differentiated from malignant liver lesions, especially metastases in the case of follow up of oncologic patients. 14,15…”

Section: Introductionmentioning

confidence: 99%

Liver Multiacinar Regenerative Nodules: Imaging Findings and Clinical Implications

Donato¹,

Andrade²,

Bastati

et al. 2018

Acta Med Port

View full text Add to dashboard Cite

RESUMOIntrodução: Nódulos regenerativos multiacinares são nódulos hepatocelulares benignos relacionados com alterações vasculares hepáticas. São muito semelhantes à hiperplasia nodular focal mas ocorrem num contexto diferente de doença hepática crónica. O objectivo deste trabalho foi descrever os achados imagiológicos principais destes nódulos e compará-los com um grupo controlo de hiperplasia nodular focal. Material e Métodos: Foi efectuada uma revisão cega de estudos por ressonância magnética de 26 casos de nódulos regenerativos multiacinares e 25 de hiperplasia nodular focal, sendo os dois grupos comparados quanto à dimensão das lesões, morfologia, margens, estrutura, aspecto em T1, T2, difusão e após contraste (incluindo na fase hepatobiliar), presença de cicatriz central e halo hipointenso. Resultados: Foram encontradas diferenças significativas entre nódulos regenerativos multiacinares e hiperplasia nodular focal quanto às dimensões das lesões (mediana 2,35 cm AIQ: 2,13 vs 6,00 cm AIQ: 5,20 respectivamente, p < 0,001), presença de halo hipointenso após contraste (n = 9 vs n = 2, p = 0,038) e de cicatriz central (n = 9 vs n = 20, p = 0,002). Não se observaram outras diferenças significativas. Discussão: Nódulos regenerativos multiacinares e hiperplasia nodular focal são globalmente muito semelhantes mas a ausência de cicatriz central e a presença de halo hipointenso deve sugerir o diagnóstico de nódulos regenerativos multiacinares. Conclusão: O reconhecimento dos achados imagiológicos de nódulos regenerativos multiacinares pode explicar alguns dos casos atípicos de hiperplasia nodular focal e prevenir biopsias desnecessárias. Pode também desencadear uma investigação mais aprofundada de anomalias vasculares hepáticas subjacentes eventualmente desconhecidas.ABSTRACT Introduction: Multiacinar regenerative nodules are benign hepatocellular nodules related to vascular disturbances of the liver. They strongly resemble conventional focal nodular hyperplasia but are connected to different clinical settings, typically chronic liver disease.The purpose of the present study was to describe the key imaging features of these lesions and compare them with a control arm of focal nodular hyperplasia. Material and Methods: A blinded consensus review of liver magnetic resonance consisting of 26 cases of multiacinar regenerative nodules and 25 cases of focal nodular hyperplasia was performed. Lesion size, shape, margins, structure, T1 and T2 signal intensity, diffusion and contrast-enhanced features (including hepatobiliary phase), presence of a central scar and of a peripheral hypointense rim were compared between the two groups. Results: Significant differences between multiacinar regenerative nodules and focal nodular hyperplasia included size (median 2.35 cm, IQR: 2.13, vs 6.00 cm, IQR: 5.20, respectively, p < 0.001), presence of a peripheral hypointense rim after contrast (n = 9 vs n = 2 cases, p = 0.038) and of a central scar (n = 9 vs n = 20, p = 0.002). There were no other significant differences. Discussion: Overall m...

show abstract

“…According to published clinical and pathological studies, the prevalence of hepatic cyst and hemangioma in the general population ranges from 0.06 to 17.8% and from 0.1 to 20%, respectively [4,5,6,7]. Focal nodular hyperplasia (FNH) and hepatic adenoma are less frequent (0.2-3.2% and 0.04-1.5%, respectively) [8,9,10]. Autopsy series have reported a high prevalence of benign focal liver lesions of 52% in patients with no known history of a malignant tumor [11].…”

Section: Introductionmentioning

confidence: 99%

Liver Imaging Techniques: Recognition of Uveal Melanoma Metastases

et al. 2018

View full text Add to dashboard Cite

Background: The liver is the most common site for metastases of several primary malignancies including uveal melanoma. Methods: Review of imaging characteristics of incidental common benign liver lesions including hepatic cyst, hemangioma, focal nodular hyperplasia, and hepatic adenoma and contrasting them with uveal melanoma metastases. Results: Benign hepatic lesions may be cystic or, if solid, relatively stable in size over time. For hepatic lesions larger than 10 mm in size, characteristic imaging features typically allow for confident diagnosis. When lesions are small (less than 10 mm), definitive characterization can be difficult. Moreover, lesions smaller than 10 mm can be difficult to biopsy under ultrasound or computed tomography (CT) guidance, and short-term follow-up will often be useful to assess for stability or progression. Overall, magnetic resonance imaging is more specific than CT scan and at least as sensitive as CT for detecting uveal melanoma liver metastases. Conclusions: New multiple enhancing solid liver lesions should raise suspicion of uveal melanoma liver metastases. Discussion of challenging cases with the radiologist may be beneficial, as pertinent information such as size, location, and molecular prognostication status of the primary tumor can guide radiological interpretation of hepatic lesions.

show abstract

Focal nodular hyperplasia-like lesions in patients with cavernous transformation of the portal vein: prevalence, MR findings and natural history

Abstract: FNH-like lesions are commonly detected in patients with CTPV. Most lesions demonstrate benign imaging findings and stable clinical course.

Cited by 49 publications

References 33 publications

Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis

Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis

Liver Multiacinar Regenerative Nodules: Imaging Findings and Clinical Implications

Liver Imaging Techniques: Recognition of Uveal Melanoma Metastases

Contact Info

Product

Resources

About