Focal positivity of immunohistochemical markers for pulmonary squamous cell carcinoma in primary pulmonary choriocarcinoma: A histopathological study

Matsukuma, Susumu; Obara, Kiyohaya; Utsumi, Yoshitaka; Miyai, Kosuke; Takeo, Hiroaki; Oshika, Y; Sensaki, Koji

doi:10.3892/ol.2018.9525

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…Abbreviations: PFS progression-free survival; PNET pulmonary neuroendocrine tumor; CEA carcinoembryonic antigen; PLR plateletlymphocyte ratio; NLR neutrophil-lymphocyte ratio; LMR lymphocyte-monocyte ratio Thunnissen et al (2017) suggested that cytokeratin CK8, CK18, CK7, and CK19 may be associated with SCLC. CK5/6, p63, and p40 are commonly used as immunohistochemical markers for squamous cell carcinoma of the lung (Matsukuma et al 2018). However, there remains conflicting views on the immunohistochemical profile.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary neuroendocrine tumors: study of 266 cases focusing on clinicopathological characteristics, immunophenotype, and prognosis

Zhang

Chen

Zhang

et al. 2022

J Cancer Res Clin Oncol

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Objective Pulmonary neuroendocrine tumors (PNETs) consist of small-cell lung cancer (SCLC), large-cell neuroendocrine carcinoma (LCNEC), typical carcinoid (TC), and atypical carcinoid (AC). We aimed to analyze the immunophenotypic, metastatic, and prognostic risk factors for PNETs. Materials and methods A total of 266 patients with PNETs were enrolled, including 219 patients with SCLC, 18 patients with LCNEC, 11 patients with TC, and 18 patients with AC. Clinicopathological characteristics and immunophenotypes were compared among the subtypes of PNETs. Risk factors for metastasis, progression-free survival (PFS), and overall survival (OS) were analyzed. Results Thyroid transcription factor-1 (TTF-1) and the Ki-67 index were significantly different among subtypes of PNETs (all P < 0.05). Smoking (OR, 2.633; P = 0.031), high pretreatment carcinoembryonic antigen (CEA > 5 ng/ml: OR, 3.084; P = 0.014), and poorly differentiated pathotypes (P = 0.001) were independent risk factors for lymph-node metastasis. Smoking (OR, 2.071; P = 0.027) and high pretreatment CEA (OR, 2.260; P = 0.007) were independent risk factors for distant metastasis. Results of the multivariate Cox regression model showed pretreatment CEA (HR, 1.674; P = 0.008) and lymphocyte–monocyte ratio (LMR) (HR = 0.478, P = 0.007) were significantly associated with PFS; BMI (P = 0.031), lymph-node metastasis (HR = 4.534, P = 0.001), poorly differentiated pathotypes (P = 0.015), platelet–lymphocyte ratio (PLR) (HR = 2.305, P = 0.004), and LMR (HR = 0.524, P = 0.045) were significantly associated with OS. Conclusions PNETs are a group of highly heterogeneous tumors with different clinical manifestations, pathological features, and prognoses. Knowing clinicopathological characteristics and immunophenotypes of PNETs is significant for diagnosis. Pretreatment PLR, LMR, and CEA have certain value in the prognosis of PNETs.

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Section: Discussionmentioning

confidence: 99%

“…In addition, Thunnissen et al ( 2017 ) suggested that cytokeratin CK8, CK18, CK7, and CK19 may be associated with SCLC. CK5/6, p63, and p40 are commonly used as immunohistochemical markers for squamous cell carcinoma of the lung (Matsukuma et al 2018 ). However, there remains conflicting views on the immunohistochemical profile.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary neuroendocrine tumors: study of 266 cases focusing on clinicopathological characteristics, immunophenotype, and prognosis

Zhang

Chen

Zhang

et al. 2022

J Cancer Res Clin Oncol

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“…Extragonadal choriocarcinomas are thought to occur by a different mechanism compared with gonadal choriocarcinomas. There are several hypotheses related to the occurrence of extragonadal choriocarcinomas: that normal tumor cells retro-differentiate into chorionic cells [16,17]: that embryonic cells arising in the embryonic phase aberrate [18], that it arises from a common progenitor cell through another differentiation pathway [19] and that the choriocarcinoma occurring in the genitals has metastasized to multiple organs and the primary tumor disappears. In cases of gastric choriocarcinomas, there are many cases combined with adenocarcinomas, so the hypothesis that it arises from retro-differentiation of an adenocarcinoma is most prevalent.…”

Section: Discussionmentioning

confidence: 99%

“…Matsukawa et al and Vallonthaiel et al have reported that pulmonary choriocarcinoma p40-positive features of cytotrophoblast-like polygonal tumor cells were focally observed in 50% of cells and CK5/6-positive trophoblastic tumor cells could be focally identified in choriocarcinomas. They have exhibited the diagnostic pitfall of primary or metastatic pulmonary choriocarcinomas, which could mimic SCCs morphologically and immunohistochemically [ 19 , 20 ]. In Table 1 , we show the typical pattern of immunohistochemical staining of a choriocarcinoma and an SCC and compare them with the immunohistochemical pattern observed in our case.…”

Section: Discussionmentioning

confidence: 99%

Surgically resected primary esophageal choriocarcinoma accompanied with Barrett’s adenocarcinoma: a case report

et al. 2020

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Background Choriocarcinomas are usually classified as either gestational or non-gestational. Primary choriocarcinomas in the gastrointestinal tract, especially primary choriocarcinomas in the esophagus, are extremely rare. We report a case of a rare primary esophageal choriocarcinoma mixed with squamous cell carcinoma-like components in association with Barrett’s adenocarcinoma. Case presentation A 58-year-old man visited the hospital, complaining of hematemesis and tarry stools. In emergency upper gastrointestinal endoscopy, a bleeding esophageal tumor was observed. Additionally, a contrast computed tomography (CT) scan showed a large hypervascular tumor 4.8 cm in diameter in the left kidney. He came to our institution for further examination and treatment of the esophageal tumor and kidney lesion. The patient had an easy bleeding elevated tumor 2 cm in diameter at the left wall of the middle thoracic esophagus and a left renal carcinoma. Histopathological diagnosis of the biopsy specimen of the esophageal tumor was a poorly differentiated carcinoma. However, a precise histological type diagnosis could not be obtained. In June 2016, mediastinoscopic transhiatal esophagectomy and posterior mediastinal gastric tube reconstruction were performed to treat his esophageal tumor. Histopathologically, most of the tumor comprised hCG-positive syncytiotrophoblasts. Therefore, we confirmed it as a primary esophageal choriocarcinoma. Furthermore, the tumor contained a poorly differentiated squamous cell carcinoma-like component that was also diagnosed as a choriocarcinoma using immunohistochemical staining and there was a small Barrett’s esophageal adenocarcinoma lesion in the Barrett's epithelium near the tumor. Three months after surgery, a CT scan demonstrated multiple lung metastatic nodules and multiple intrahepatic masses. Needle biopsy from the lung nodule showed a choriocarcinoma. Despite chemotherapy, the metastatic choriocarcinoma regrew rapidly and multiple bone metastases appeared. He died because of his esophageal choriocarcinoma 13 months after primary resection. Conclusions We encountered an extremely rare case of esophageal choriocarcinoma combined with squamous cell carcinoma-like components in association with a simultaneous Barrett’s adenocarcinoma that we followed for the entire course of his disease, from resection to end of life. Esophageal choriocarcinomas are rare with peculiar characteristics and very poor prognoses. Additional cases are needed to establish an appropriate future treatment.

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Disseminated Primary Pulmonary Choriocarcinoma Successfully Treated by Chemotherapy: A Case Report and Literature Review

Kim

Jae

Kim

et al. 2020

Cancer Investigation

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Focal positivity of immunohistochemical markers for pulmonary squamous cell carcinoma in primary pulmonary choriocarcinoma: A histopathological study

Cited by 4 publications

References 34 publications

Pulmonary neuroendocrine tumors: study of 266 cases focusing on clinicopathological characteristics, immunophenotype, and prognosis

Pulmonary neuroendocrine tumors: study of 266 cases focusing on clinicopathological characteristics, immunophenotype, and prognosis

Surgically resected primary esophageal choriocarcinoma accompanied with Barrett’s adenocarcinoma: a case report

Disseminated Primary Pulmonary Choriocarcinoma Successfully Treated by Chemotherapy: A Case Report and Literature Review

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