Focal Segmental Glomerulosclerosis in a Patient with Polycythemia Rubra Vera

Sharma, RK; Kohli, Harbir Singh; Arora, Puneet; Gupta, Arun; Murari, Manjula; Pandey, R M; Kher, Vijay; Das, B.K.

doi:10.1159/000188499

Cited by 16 publications

(12 citation statements)

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“…The histological results for these cases of PV associated with renal disease included 8 cases (38.1%) of IgAN (5-11), 10 cases (47.6%) of focal segmental glomerulosclerosis (FSGS) (3,(12)(13)(14)(15)(16)(17)(18)(19), 2 cases (9.5%) of membranoproliferative glomerulonephritis (MPGN) (20,21) and 1 case (4.8%) of rapidly progressive glomerulonephritis (RPGN) .…”

Section: Discussionmentioning

confidence: 99%

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Polycythemia vera associated with IgA nephropathy: A case report and literature review

Chen¹,

Zhang²,

Li³

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. A case of polycythemia vera (PV) associated with immunoglobulin A nephropathy (IgAN) in a 57-year-old man is described. The patient had a mild enlargement of the kidneys and elevated serum creatinine level, whereas the glomerular filtration rate was normal. Pathological observation under a light microscope showed mild mesangial hyperplasia. The urinary protein level was found to be positively correlated with changes in blood cell counts. After controlling blood pressure, anti-platelet, hydroxyurea treatment, the patient's proteinuria decreased and renal function remained in the normal range. PV associated with renal disease is rare and generally considered to be associated with hypervolemia or high-viscosity-induced renal hyperperfusion and hyperfiltration. This is a rare case of PV associated with IgAN without a high filtration rate. A review of the clinical features of PV associated with renal disease from previous literature was also conducted. The histological results of the cases varied and included IgAN, focal segmental glomerulosclerosis and membranoproliferative glomerulonephritis.

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Section: Discussionmentioning

confidence: 99%

“…Ten cases of PV associated with FSGS have been reported (3,(12)(13)(14)(15)(16)(17)(18)(19). The average age was 55.8 years with a male-to-female ratio of 0.67.…”

Section: Discussionmentioning

confidence: 99%

Polycythemia vera associated with IgA nephropathy: A case report and literature review

Chen¹,

Zhang²,

Li³

et al. 2015

Experimental and Therapeutic Medicine

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“…Although several cases of glomerulonephritis associated with MPN have been reported, the etiologies of the renal disorders were not established (Plomley et al, Aust NZ J Med, 13:125–129, 1983; Sharma et al, Nephron, 69:361, 1995; Kanauchi et al, Intern Med, 33:36–40, 1994; Kasuno et al, Nephrol Dial Transplant, 12:212–215, 1997; Au et al, Am J Kid Dis, 34:889–893, 1999; Kosch et al, Nephrol Dial Transplant, 15:1710–1711, 2000; Oymak et al, Nephron, 86:346–347, 2000; Chun et al, Am J Nephrol, 20:344–346, 2000; Chung et al, Am J Nephrol, 22:397–401, 2002; Asaba et al, Clin Exp Nephrol, 7:296–300, 2003; Haraguchi et al, Clin Exp Nephrol, 10:74–77, 2006; Saigusa et al, J Nephrol, 19:656–658, 2006; Okuyama et al, Clin Nephrol, 6:412–415, 2007; Nishi et al, Clin Nephrol, 5:393–398, 2010; Ulusoy et al, Intern Med, 49:2477, 2010). A review of previous reports of renal biopsy cases with MPN in the English literature suggested that circulation control is important for the treatment of renal disorders that mimic glomerulonephritis in MPN.…”

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confidence: 99%

Renal biopsy cases in myeloproliferative neoplasms (MPN)

Fujita

Hatta

2013

CEN Case Rep

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We performed renal biopsy in three cases complicated by myeloproliferative neoplasms (MPN). Although several cases of glomerulonephritis associated with MPN have been reported, the etiologies of the renal disorders were not established (Plomley et al., Aust NZ J Med, 13:125–129, 1983; Sharma et al., Nephron, 69:361, 1995; Kanauchi et al., Intern Med, 33:36–40, 1994; Kasuno et al., Nephrol Dial Transplant, 12:212–215, 1997; Au et al., Am J Kid Dis, 34:889–893, 1999; Kosch et al., Nephrol Dial Transplant, 15:1710–1711, 2000; Oymak et al., Nephron, 86:346–347, 2000; Chun et al., Am J Nephrol, 20:344–346, 2000; Chung et al., Am J Nephrol, 22:397–401, 2002; Asaba et al., Clin Exp Nephrol, 7:296–300, 2003; Haraguchi et al., Clin Exp Nephrol, 10:74–77, 2006; Saigusa et al., J Nephrol, 19:656–658, 2006; Okuyama et al., Clin Nephrol, 6:412–415, 2007; Nishi et al., Clin Nephrol, 5:393–398, 2010; Ulusoy et al., Intern Med, 49:2477, 2010). A review of previous reports of renal biopsy cases with MPN in the English literature suggested that circulation control is important for the treatment of renal disorders that mimic glomerulonephritis in MPN.

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“…Although several reports have presented secondary erythrocytosis associated with renal glomerular diseases [2][3][4][5][6], simultaneous occurrence of PV and glomerular diseases in the same patient has rarely been published in the English literature. Only a few reports described PV associated with diffuse mesangial proliferative glomerulonephritis (GN) [7], Henoch-Schönlein purpura (HSP) nephritis [8], focal segmental glomerulosclerosis (FSGS) [9,10], and IgA nephropathy (IgAN) [11]. In spite of IgAN being the most common GN worldwide, there have been only 2 cases of IgAN in patients with PV [11].…”

Section: Introductionmentioning

confidence: 99%

IgA Nephropathy in a Patient with Polycythemia vera

Chung

Park²,

Song³

2002

Am J Nephrol

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IgA nephropathy (IgAN) is one of the most frequent forms of glomerulonephritis (GN). However, its association with polycythemia vera (PV) has rarely been described. We report a case of IgAN combined with PV. The patient was a 46-year-old male with chronic renal failure, heavy proteinuria and erythrocytosis. He also presented hypertension and hematuria as well as splenomegaly, high arterial oxygen saturation and elevated leukocyte alkaline phosphatase activity. Possible causes of secondary erythrocytosis were ruled out. The renal biopsy revealed mesangial proliferative GN with predominant IgA deposition in mesangium. He was diagnosed as having IgAN and PV concomitantly. After administration of hydroxyurea, enalapril and felodipine, blood cell count and blood pressure normalized, while azotemia persisted. There was also a partial remission of the heavy proteinuria. We describe a case of IgAN associated with PV, and possible pathophysiologic relationships between two diseases are discussed with review of the literature.

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Focal Segmental Glomerulosclerosis in a Patient with Polycythemia Rubra Vera

Cited by 16 publications

References 0 publications

Polycythemia vera associated with IgA nephropathy: A case report and literature review

Polycythemia vera associated with IgA nephropathy: A case report and literature review

Renal biopsy cases in myeloproliferative neoplasms (MPN)

IgA Nephropathy in a Patient with Polycythemia vera

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