Focal Segmental Glomerulosclerosis in Kidney Resected for Renal Cell Carcinoma

Ejaz, A. Ahsan; Geiger, Xochi; Wasiluk, Andrew

doi:10.1007/s11255-004-1466-0

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Magyarlaki et al [21] reported 5 cases (8%) of focal segmental glomerulosclerosis in 60 autopsy cases of renal cell carcinoma, however, there are only a few reports of focal segmental glomerulosclerosis with renal cell carcinoma [52] and Wilms' tumor [53]. Glomerulosclerotic lesions are often observed in the renal parenchyma adjacent to a tumor, so parenchymal compression and urinary outflow obstruction by renal tumor may be involved in the development of focal segmental glomerulosclerosis.…”

Section: Minimal Change Disease and Focal Segmental Glomerulosclerosimentioning

confidence: 99%

Paraneoplastic Glomerulopathy Associated with Renal Cell Carcinoma

Tojo¹

2013

Renal Tumor

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Figure . However, when VHL protein is lost in clear cell renal cell carcinoma, various cytokines and growth factors induced by HIFare enhanced vascular endothelial growth factor VEGF which stimulates angiogenesis of carcinoma, platelet-derived growth factor PDGF and transforming growth factor alpha TGF-, which lead to tumor growth, glucose transporter GLUT-and carbonic anhydrase IX CA IX , which leads to tumor cell survival in an acidic environment [ -]. NF-kB activity is also regulated by VHL protein, and cytokine-inducible transcription factors including NF-kB and STAT are activated in renal cell carcinoma [ -]. Renal cell carcinoma tissue and cell lines of the tumor express mRNA of IL-and IL-receptor [ , ], which may play a role in cancer cell growth in an autocrine or paracrine manner. Renal Tumor

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Section: Minimal Change Disease and Focal Segmental Glomerulosclerosimentioning

confidence: 99%

Paraneoplastic Glomerulopathy Associated with Renal Cell Carcinoma

Tojo¹

2013

Renal Tumor

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Nonneoplastic Kidney Diseases in Adult Tumor Nephrectomy and Nephroureterectomy Specimens: Common, Harmful, Yet Underappreciated

Henriksen

Meehan

Chang

2009

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Nonneoplastic kidney diseases, such as arterionephrosclerosis and/or diabetic nephropathy, are commonly encountered in tumor nephrectomy and nephroureterectomy specimens. Although any nonneoplastic kidney disease may be encountered in these resection specimens by chance, additional diseases that may be related to the underlying neoplasm or its treatment regimen include thrombotic microangiopathy, Amyloid A amyloidosis, membranous nephropathy, immunoglobulin A nephropathy, membranoproliferative glomerulonephritis, pauci-immune crescentic glomerulonephritis, focal segmental glomerulosclerosis, minimal-change disease, acute interstitial nephritis, and xanthogranulomatous pyelonephritis. Given the morbidity of chronic kidney disease and the relatively favorable 5-year survival rates for urothelial and renal cell carcinomas, accurate evaluation of the nonneoplastic kidney parenchyma is important. Objectives.—We will discuss our approach for evaluating the nonneoplastic kidney parenchyma in tumor nephrectomy and nephroureterectomy specimens. The pathologic features of the aforementioned kidney diseases as well as pertinent references will be reviewed. The identification of glomerular abnormalities, including mesangial sclerosis or hypercellularity, segmental sclerosis, crescent formation, glomerulitis, or glomerular basement membrane alterations, should lead to additional immunofluorescence and electron microscopic studies. Safeguards to ensure that the nonneoplastic parenchyma is not overlooked include adding this important parameter to synoptic reports and obtaining periodic acid–Schiff and/or Jones methenamine silver stains prior to microscopic evaluation of the neoplasm. Data Sources.—Relevant literature and University of Chicago Medical Center pathology archives. Conclusions.—The practicing surgical pathologist should be aware of the importance of both correctly classifying the resected renal or urothelial neoplasm and the concomitant nonneoplastic kidney disease that may be present in these specimens.

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Focal Segmental Glomerulosclerosis in Kidney Resected for Renal Cell Carcinoma

Cited by 2 publications

References 5 publications

Paraneoplastic Glomerulopathy Associated with Renal Cell Carcinoma

Paraneoplastic Glomerulopathy Associated with Renal Cell Carcinoma

Nonneoplastic Kidney Diseases in Adult Tumor Nephrectomy and Nephroureterectomy Specimens: Common, Harmful, Yet Underappreciated

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