Focalized Pulmonary Histoplasmosis (Coin Lesion): A Report of 58 Cases

Sutaria, Maganlal; Polk, John W.; Reddy, Prathapchandra

doi:10.1378/chest.61.4.361

Cited by 8 publications

(8 citation statements)

References 19 publications

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“…Half of the patients were asymptomatic in a case series of 58 patients, and cough (38%), chest pain (26%), and fever (17%) were the common symptoms in symptomatic patients, while weight loss, hemoptysis, and dyspnea were rarely reported [6]. Histoplasmoma forms due to excessive healing of the primary focus resulting in fibrosis, forming lesions 2-4 mm in size and rarely can progress up to 4 cm [6]. Since they are asymptomatic, remain small and stable in length, and enlarge slowly over time [7,8].…”

Section: Discussionmentioning

confidence: 99%

An unanticipated pulmonary mass: Histoplasmoma mimicking malignancy

Ahmed¹,

Mustafeez²,

Hamid³

et al. 2021

Int J Case Rep Images

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Histoplasmoma is a rare form of chronic infection with Histoplasma capsulatum (HC) infection that is frequently misconstrued as malignancy. The diagnosis is invariably through histopathological studies and appropriate staining after surgical resection and carries an excellent prognosis even for lesions more than 3 cm.We present a case of a young female whose clinical presentation and imaging studies were highly concerning for lung malignancy, such as non-Hodgkin's lymphoma (NHL) in controlled human immunodeficiency (HIV) infection and was resected accordingly. However, on histopathological examination, it was revealed to be a histoplasmoma. There were no signs of disseminated disease; hence antifungal therapy was not administered. The patient remained asymptomatic at outpatient followup after a year.Infectious etiology should make the differential list when working up a pulmonary nodule or even a mass inappropriate setting, including well managed immunocompromised conditions. These are potentially treatable causes with an excellent prognosis. It is important to recall that such infections might have

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Section: Discussionmentioning

confidence: 99%

An unanticipated pulmonary mass: Histoplasmoma mimicking malignancy

Ahmed¹,

Mustafeez²,

Hamid³

et al. 2021

Int J Case Rep Images

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“…Symptom-wise, an enlightening report of 58 cases by Sutaria et al25 reveals that half of the patients were asymptomatic and presented to the hospital for evaluation after a routine chest radiogram. The symptomatic half complained most frequently of cough (38%), chest pain (26%), fever (17%), and fatigue (12%), which occurs several weeks after exposure.…”

Section: Discussionmentioning

confidence: 99%

“…The best approach for obtaining tissue varies with the location and size of the lesion, as well as the level of suspicion for malignancy. Transthoracic fine-needle aspiration or wedge resection are good options for most patients with peripherally located lesions 25 , 28…”

Section: Discussionmentioning

confidence: 99%

Pulmonary histoplasmoma: a disguised malady

Matos¹,

Felipe-Silva²,

Otoch³

2018

Autops. Case Rep.

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Histoplasmosis is a mycosis caused by the dimorphic fungus, Histoplasma capsulatum, which is transmitted via dust and aerosols. Lung involvement is the most common, with a varied clinical presentation. Although it is not the only source of infection, H. capsulatum is frequently found in bat guano, which is the reason why it is highly prevalent among caving practitioners. The solitary histoplasmoma of the lung is an unusual and chronic manifestation of this entity, which mimics, or at least is frequently misconstrued, as a malignancy. Almost invariably, the diagnosis of this type of histoplasmosis presentation is achieved after lung biopsy. The authors present the case of a young woman who sought medical care because of chest pain. The diagnostic work-up revealed the presence of a pulmonary nodule. She was submitted to a thoracotomy and wedge pulmonary resection. The histologic analysis rendered the diagnosis of histoplasmoma. This report aims to call attention to this diagnosis as the differential diagnosis of a pulmonary nodule.

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“…The most commonly reported etiology for pediatric lung nodules is calcified granulomatous disease, usually fungal in nature. Approximately 50% of fungal pulmonary nodules are asymptomatic at discovery as reported in a large case series . We report the case of an 8‐year‐old male referred for persisting pneumonia and concern for pulmonary nodules that was found to have a cardiac fibroma and an anomalous course of his pulmonary veins and was diagnosed with Gorlin syndrome.…”

Section: Introductionmentioning

confidence: 89%

“…Approximately 50% of fungal pulmonary nodules are asymptomatic at discovery as reported in a large case series. 1 We report the case of an 8-year-old male referred for persisting pneumonia and concern for pulmonary nodules that was found to have a cardiac fibroma and an anomalous course of his pulmonary veins and was diagnosed with Gorlin syndrome. In this case report we will highlight the existing literature on pulmonary findings in Gorlin syndrome as well as a novel description of pulmonary venous abnormalities in this syndrome.…”

Section: Introductionmentioning

confidence: 99%