Focus and Insights into the Synthetic Biology-Mediated Chassis of Economically Important Fungi for the Production of High-Value Metabolites

Tiwari, Pragya; Dufossé, Laurent

doi:10.3390/microorganisms11051141

Cited by 8 publications

(2 citation statements)

References 182 publications

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“…Microbial metabolism is a valuable source of high-value compounds. Nevertheless, their industrial application could be limited since they are obtained in low concentrations [70]. Therefore, improving precursor supply and other strategies have been adopted to increase the production of these molecules [71], in addition to classical and molecular techniques for strain enhancement.…”

Section: Using Precursors To Enhance Secondary Metabolite Productionmentioning

confidence: 99%

Strategies for Supplying Precursors to Enhance the Production of Secondary Metabolites in Solid-State Fermentation

Méndez-Hernández,

Rodríguez-Durán,

Páez-Lerma

et al. 2023

Fermentation

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The production of secondary metabolites can be improved with the supply of precursors both in submerged and solid-state fermentation (SSF). Microorganisms assimilate the precursors and biotransform them to excrete compounds of commercial interest. The raw materials used in SSF, frequently agro-industrial residues, may contain molecules that serve as precursors for secondary metabolites. However, supplying a precursor can dramatically improve crop production. Commonly, precursors are added as part of the liquid with which the solid material to be fermented is moistened. However, recently it has been proposed to take advantage of the oxygen supply for the gradual supply of volatile precursors. It can help to avoid toxicity problems with the precursors. The present work reviews the strategies to supply precursors to improve the production of secondary metabolites in solid-state fermentation.

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Section: Using Precursors To Enhance Secondary Metabolite Productionmentioning

confidence: 99%

Strategies for Supplying Precursors to Enhance the Production of Secondary Metabolites in Solid-State Fermentation

Méndez-Hernández,

Rodríguez-Durán,

Páez-Lerma

et al. 2023

Fermentation

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show abstract

“…The recent era has witnessed the increased recognition of plant-associated microbes in key biotechnological applications including agriculture, ecosystem restoration, and areas of socio-economic concerns [ 20 , 21 ]. Rhizospheric microbes enhance plant tolerance to abiotic stress through various mechanisms, comprising phytohormone production, mineral solubilization, nitrogen fixation, and plant defense against several fungal and bacterial pathogens [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Plant-Microbe Interactions under the Extreme Habitats and Their Potential Applications

Tiwari,

Bose,

Park

et al. 2024

Microorganisms

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Plant-microbe associations define a key interaction and have significant ecological and biotechnological perspectives. In recent times, plant-associated microbes from extreme environments have been extensively explored for their multifaceted benefits to plants and the environment, thereby gaining momentum in global research. Plant-associated extremophiles highlight ubiquitous occurrences, inhabiting extreme habitats and exhibiting enormous diversity. The remarkable capacity of extremophiles to exist in extreme environmental conditions is attributed to the evolution of adaptive mechanisms in these microbes at genetic and physiological levels. In addition, the plant-associated extremophiles have a major impact in promoting plant growth and development and conferring stress tolerance to the host plant, thereby contributing immensely to plant adaptation and survival in extreme conditions. Considering the major impact of plant-associated extremophiles from a socio-economic perspective, the article discusses their significance in emerging biotechnologies with a key focus on their ecological role and dynamic interaction with plants. Through this article, the authors aim to discuss and understand the favorable impact and dynamics of plant-associated extremophiles and their biotechnological utilities.

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Current trends, limitations and future research in the fungi?

Hyde,

Baldrian,

Chen

et al. 2024

Fungal Diversity

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The field of mycology has grown from an underappreciated subset of botany, to a valuable, modern scientific discipline. As this field of study has grown, there have been significant contributions to science, technology, and industry, highlighting the value of fungi in the modern era. This paper looks at the current research, along with the existing limitations, and suggests future areas where scientists can focus their efforts, in the field mycology. We show how fungi have become important emerging diseases in medical mycology. We discuss current trends and the potential of fungi in drug and novel compound discovery. We explore the current trends in phylogenomics, its potential, and outcomes and address the question of how phylogenomics can be applied in fungal ecology. In addition, the trends in functional genomics studies of fungi are discussed with their importance in unravelling the intricate mechanisms underlying fungal behaviour, interactions, and adaptations, paving the way for a comprehensive understanding of fungal biology. We look at the current research in building materials, how they can be used as carbon sinks, and how fungi can be used in biocircular economies. The numbers of fungi have always been of great interest and have often been written about and estimates have varied greatly. Thus, we discuss current trends and future research needs in order to obtain more reliable estimates. We address the aspects of machine learning (AI) and how it can be used in mycological research. Plant pathogens are affecting food production systems on a global scale, and as such, we look at the current trends and future research needed in this area, particularly in disease detection. We look at the latest data from High Throughput Sequencing studies and question if we are still gaining new knowledge at the same rate as before. A review of current trends in nanotechnology is provided and its future potential is addressed. The importance of Arbuscular Mycorrhizal Fungi is addressed and future trends are acknowledged. Fungal databases are becoming more and more important, and we therefore provide a review of the current major databases. Edible and medicinal fungi have a huge potential as food and medicines, especially in Asia and their prospects are discussed. Lifestyle changes in fungi (e.g., from endophytes, to pathogens, and/or saprobes) are also extremely important and a current research trend and are therefore addressed in this special issue of Fungal Diversity.

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Focus and Insights into the Synthetic Biology-Mediated Chassis of Economically Important Fungi for the Production of High-Value Metabolites

Cited by 8 publications

References 182 publications

Strategies for Supplying Precursors to Enhance the Production of Secondary Metabolites in Solid-State Fermentation

Strategies for Supplying Precursors to Enhance the Production of Secondary Metabolites in Solid-State Fermentation

Plant-Microbe Interactions under the Extreme Habitats and Their Potential Applications

Current trends, limitations and future research in the fungi?

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