“…179 Single center observational studies from different parts of the world, as well as multinational national registry studies have reported that the rates of PD-related infections have steadily decreased over the last 10-20 years. 180,[186][187][188][189][190][191][192][193] Within Australia, country-wide PD-related peritonitis rates fell significantly by 37% over a 5-year period from 0.62 episodes per patient-year in 2008 to 0.39 episodes per patient-year in 2013 after a concerted, multidisciplinary and multipronged national peritonitis reduction campaign involving quarterly audit and feedback of individual unit peritonitis rates, prioritization of peritonitis prevention trials by the Australasian Kidney Trials Network, updating national clinical practice guidelines on peritonitis, launching peritonitis guideline implementation projects, publishing of a call to action paper, establishment of a PD Academy to provide PD training to junior nephrologists and nursing staff, and development of a Home Dialysis Network to support home dialysis patients (http:// homedialysis.org.au/). 161,[180][181][182][183][184][185] These reductions have been variously attributed to the use of twin bag disconnection systems, implementation of mupirocin chemoprophylaxis protocols, topical exit site application of gentamicin, coprescription of nystatin or fluconazole with antibiotic therapy, improved training of PD patients and/or staff, and better identification and targeting of peritonitis risk factors.…”