Focus on Pitavastatin

Carella, Angelo Michele; Marinelli, Teresa; Melfitano, Armando; Pumpo, Michele; Conte, M; Modola, Giovanni; Puntonio, Maria; Benvenuto, Angelo

doi:10.15379/2410-2822.2016.03.01.03

Cited by 2 publications

(1 citation statement)

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“…Further research is warranted on the mechanisms of action underlying antidiabetic herb-drug interactions. CYP monoxygenase and P-glycoprotein drug transport pathways are of particular interest given that many antidiabetic medications are subject to metabolism by these enzyme systems [95][96][97].…”

Section: Discussionmentioning

confidence: 99%

A review of the mechanisms of action and clinical consequences of interactions between antidiabetic medications and botanicals

Divyank R. Patil,

Saket R. Patil,

Parikshit S. Sarode

et al. 2024

World J. Bio. Pharm. Health Sci.

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Diabetes is a complex condition with a variety of causes and patho-physiologies. The current single target approach has not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their main stream treatments, which may present both a benefit as well as potential risk to effective management of their disease. In this review, we evaluate the clinical and experimental literature on herb–drug interactions in the treatment of diabetes. Pharmacokinetic and pharmaco-dynamic interactions between drugs and herbs are discussed, and some commonly used herbs, which can interact with antidiabetic drugs summarized. Herb–drug interactions can be a double-edgeds word presenting both risks (adverse drug events) and benefits (through enhancement). There is a general lack of data on herb–drug interactions. As such, more rigorous scientific research is urgently needed to guide clinical practice as well as to safeguard the wellbeing of diabetes patients.

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Section: Discussionmentioning

confidence: 99%

A review of the mechanisms of action and clinical consequences of interactions between antidiabetic medications and botanicals

Divyank R. Patil,

Saket R. Patil,

Parikshit S. Sarode

et al. 2024

World J. Bio. Pharm. Health Sci.

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Interaction of Statins with Grapefruit Juice

ATEŞ,

ŞAHİN

2023

Fabad J Pharm Sci

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Grapefruit juice, which discovered to interact with felodipine for the first time, is now known to interact with more that 80 drugs. Statins are among the drugs that interact with grapefruit juice. Grapefruit juice-statin interactions were first investigated in 1998 in human pharmacokinetic studies with lovastatin and simvastatin. The pharmacokinetic and pharmacodynamic basis of the interaction has been extensively investigated in studies. Flavonoids and furanocoumarins, the main components of grapefruit juice, have been reported to cause drug interactions. Furthermore, statin-grapefruit juice interactions occur mostly through inhibition of cytochrome-3A4 (CYP3A4), to a lesser extent through inhibition of P-glycoprotein (P-gp) and organic anion transporting polypeptides (OATPs). Changes in plasma drug levels as a result of interaction may increase the side-effect of statins or reduce their therapeutic efficacy. Therefore, patients using statins are generally advised to avoid grapefruit juice consumption.

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Focus on Pitavastatin

Cited by 2 publications

References 0 publications

A review of the mechanisms of action and clinical consequences of interactions between antidiabetic medications and botanicals

A review of the mechanisms of action and clinical consequences of interactions between antidiabetic medications and botanicals

Interaction of Statins with Grapefruit Juice

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