Focused Ultrasound and External Beam Radiation Therapy for Painful                     Bone Metastases: A Phase II Clinical Trial

Napoli, Alessandro; Maio, Alessandro De; Alfieri, Giulia; Gasperini, Chiara; Scipione, Roberto; Campanacci, Laura; Siepe, G.; Felice, Francesca De; Siniscalchi, Benedetta; Chiurchioni, Lorenzo; Tombolini, Vincenzo; Donati, Davide Maria; Morganti, Alessio Giuseppe; Ghanouni, Pejman; Catalano, Carlo; Bazzocchi, Alberto

doi:10.1148/radiol.211857

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…Although palliative treatments have not been shown to make a significant positive impact on the survival of patients with BM, they can be highly effective for improving patient quality of life by providing rapid symptom relief[ 41 , 42 ]. Therefore, considering the unsatisfactory results of emerging therapies and the current absence of viable cures, palliative care is considered the best option for patients with BM to maintain a relatively high quality of life at the end of life[ 43 ].…”

Section: Discussionmentioning

confidence: 99%

What enlightenment has the development of lung cancer bone metastasis brought in the last 22 years

Chen,

et al. 2024

World J Clin Oncol

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BACKGROUND Lung cancer bone metastasis (LCBM) is a disease with a poor prognosis, high risk and large patient population. Although considerable scientific output has accumulated on LCBM, problems have emerged, such as confusing research structures. AIM To organize the research frontiers and body of knowledge of the studies on LCBM from the last 22 years according to their basic research and translation, clinical treatment, and clinical diagnosis to provide a reference for the development of new LCBM clinical and basic research. METHODS We used tools, including R, VOSviewer and CiteSpace software, to measure and visualize the keywords and other metrics of 1903 articles from the Web of Science Core Collection. We also performed enrichment and protein-protein interaction analyses of gene expression datasets from LCBM cases worldwide. RESULTS Research on LCBM has received extensive attention from scholars worldwide over the last 20 years. Targeted therapies and immunotherapies have evolved into the mainstream basic and clinical research directions. The basic aspects of drug resistance mechanisms and parathyroid hormone-related protein may provide new ideas for mechanistic study and improvements in LCBM prognosis. The produced molecular map showed that ribosomes and focal adhesion are possible pathways that promote LCBM occurrence. CONCLUSION Novel therapies for LCBM face animal testing and drug resistance issues. Future focus should centre on advancing clinical therapies and researching drug resistance mechanisms and ribosome-related pathways.

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Section: Discussionmentioning

confidence: 99%

What enlightenment has the development of lung cancer bone metastasis brought in the last 22 years

Chen,

et al. 2024

World J Clin Oncol

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“…The findings indicate that MRgFUS is a feasible and efficient substitute for alleviating pain in individuals with bone metastases. It presents fewer adverse effects and enhances the overall quality of life when compared to traditional radiation therapy [259].…”

Section: Radiation Therapy Application and Radiopharmaceutical Usagementioning

confidence: 99%

Intersecting Paths: Unraveling the Complex Journey of Cancer to Bone Metastasis

Arakil,

Akhund,

Elaasser

et al. 2024

Biomedicines

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The phenomenon of bone metastases presents a significant challenge within the context of advanced cancer treatments, particularly pertaining to breast, prostate, and lung cancers. These metastatic occurrences stem from the dissemination of cancerous cells into the bone, thereby interrupting the equilibrium between osteoblasts and osteoclasts. Such disruption results in skeletal complications, adversely affecting patient morbidity and quality of life. This review discusses the intricate interplay between cancer cells and the bone microenvironment, positing the bone not merely as a passive recipient of metastatic cells but as an active contributor to cancer progression through its distinctive biochemical and cellular makeup. A thorough examination of bone structure and the dynamics of bone remodeling is undertaken, elucidating how metastatic cancer cells exploit these processes. This review explores the genetic and molecular pathways that underpin the onset and development of bone metastases. Particular emphasis is placed on the roles of cytokines and growth factors in facilitating osteoclastogenesis and influencing osteoblast activity. Additionally, this paper offers a meticulous critique of current diagnostic methodologies, ranging from conventional radiography to advanced molecular imaging techniques, and discusses the implications of a nuanced understanding of bone metastasis biology for therapeutic intervention. This includes the development of targeted therapies and strategies for managing bone pain and other skeletal-related events. Moreover, this review underscores the imperative of ongoing research efforts aimed at identifying novel therapeutic targets and refining management approaches for bone metastases. It advocates for a multidisciplinary strategy that integrates advancements in medical oncology and radiology with insights derived from molecular biology and genetics, to enhance prognostic outcomes and the quality of life for patients afflicted by this debilitating condition. In summary, bone metastases constitute a complex issue that demands a comprehensive and informed approach to treatment. This article contributes to the ongoing discourse by consolidating existing knowledge and identifying avenues for future investigation, with the overarching objective of ameliorating patient care in the domain of oncology.

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“…As a mechanical wave that differs from light waves, ultrasound has been widely used in both diagnosis and treatment in the medical field [10][11][12]. Sonodynamic therapy (SDT) was first discovered in 1989, when Umemura et al observed that hematoporphyrin showed little cytotoxicity without external intervention but exhibited remarkable killing ability under ultrasound irradiation [13,14].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy

Chen

Zhang

Shah

et al. 2023

IJMS

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Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has the advantages of deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role in the process of SDT, as their structure and properties directly determine the treatment outcome. Inorganic sonosensitizers, with their high stability and longer circulation time in the human body, have great potential in SDT. In this review, the possible mechanisms of SDT including the ultrasonic cavitation, reactive oxygen species generation, and activation of immunity are briefly discussed. Then, the latest research progress on inorganic sonosensitizers is systematically summarized. Subsequently, strategies for optimizing treatment efficacy are introduced, including combination therapy and image-guided therapy. The challenges and future prospects of sonodynamic therapy are discussed. It is hoped that this review will provide some guidance for the screening of inorganic sonosensitizers.

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Focused Ultrasound and External Beam Radiation Therapy for Painful Bone Metastases: A Phase II Clinical Trial

Cited by 8 publications

References 32 publications

What enlightenment has the development of lung cancer bone metastasis brought in the last 22 years

What enlightenment has the development of lung cancer bone metastasis brought in the last 22 years

Intersecting Paths: Unraveling the Complex Journey of Cancer to Bone Metastasis

A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy

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