Focused ultrasound as an evolving therapy for Parkinson's disease

Fishman, Paul S.; Lipsman, Nir

doi:10.1002/mds.27809

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…Ultrasonic neuromodulation was first described in 1957 by Fry, showing that focused ultrasound (FUS) could be employed non-invasively for non-reversible ablation and reversible modulation of biological tissue in both the central and peripheral nervous system [ 1 ]. The former (ablative) approach, based on high-intensity transcranial FUS (tFUS) and its mainly thermal effects, has so far seen the most significant development, garnering FDA approval as a non-invasive alternative to surgical interventions for the treatment of essential tremor [ 2 ], Parkinson’s Disease [ 3 ], benign prostatic hyperplasia [ 4 ], prostate cancer [ 5 ], uterine fibroids [ 6 ], bone metastases [ 7 ], and osteoid osteoma [ 8 ]. The latter (modulatory) approach, based on low-intensity tFUS and, putatively, mechanical agitation [ 9 ], is now (re)emerging as a non-invasive neuromodulatory technique for studying the human brain in both the basic and clinical neuroscientific contexts [ 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Focusing in on the Future of Focused Ultrasound as a Translational Tool

2022

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Section: Introductionmentioning

confidence: 99%

Focusing in on the Future of Focused Ultrasound as a Translational Tool

2022

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“…Magnetic resonance guided focused ultrasound (MRgFUS) has emerged as a non-invasive treatment modality in a number of applications, such as essential tremor [1][2][3], Parkinson's disease [4][5][6], neuropathy [7,8], epilepsy [9], blood-brain barrier opening [10][11][12][13], and Alzheimer's disease [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Characterization of a Low-Profile, Flexible, and Acoustically Transparent Receive-Only MRI Coil Array for High Sensitivity MR-Guided Focused Ultrasound

Saniour

Robb²,

Taracila³

et al. 2022

IEEE Access

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Magnetic resonance guided focused ultrasound (MRgFUS) is a non-invasive therapeutic modality for neurodegenerative diseases that employs real-time imaging and thermometry monitoring of targeted regions. MRI is used in guidance of ultrasound treatment; however, the MR image quality in current clinical applications is poor when using the vendor built-in body coil. We present an 8-channel, ultra-thin, flexible, and acoustically transparent receive-only head coil design (FUS-Flex) to improve the signal-to-noise ratio (SNR) and thus the quality of MR images during MRgFUS procedures. Acoustic simulations/experiments exhibit transparency of the FUS-Flex coil as high as 97% at 650 kHz. Electromagnetic simulations show an SNR increase of 13× over the body coil. In vivo results show an increase of the SNR over the body coil by a factor of 7.3 with 2× acceleration (equivalent to 11× without acceleration) in the brain of a healthy volunteer, which agrees well with simulation. These preliminary results show that the use of a FUS-Flex coil in MRgFUS surgery can increase MR image quality, which could yield improved focal precision, real-time intraprocedural anatomical imaging, and real-time 3D thermometry mapping.

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“…[ 7 ] Low‐intensity ultrasound has been used to stimulate various brain regions of the human, including the thalamus, [ 8 ] the prefrontal, visual, [ 9 ] motor, [ 10 ] and somatosensory cortices. [ 11 , 12 , 13 , 14 ] It is also under study as a possible treatment for a range of neurological disorders, such as Alzheimer's disease, [ 15 , 16 ] Parkinson's disease, [ 17 , 18 , 19 ] epilepsy, [ 20 ] depression, [ 21 ] and amyotrophic lateral sclerosis. [ 22 ] Ultrasound has thus shown the ability to affect the functioning of the central nervous system without significant accompanying damage.…”

Section: Introductionmentioning

confidence: 99%

Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators

et al. 2021

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Ultrasound is a promising new modality for non-invasive neuromodulation. Applied transcranially, it can be focused down to the millimeter or centimeter range. The ability to improve the treatment's spatial resolution to a targeted brain region could help to improve its effectiveness, depending upon the application. The present paper details a neurostimulation scheme using gas-filled nanostructures, gas vesicles (GVs), as actuators for improving the efficacy and precision of ultrasound stimuli. Sonicated primary neurons display dose-dependent, repeatable Ca 2+ responses, closely synced to stimuli, and increased nuclear expression of the activation marker c-Fos in the presence of GVs. GV-mediated ultrasound triggered rapid and reversible Ca 2+ responses in vivo and could selectively evoke neuronal activation in a deep-seated brain region. Further investigation indicate that mechanosensitive ion channels are important mediators of this effect. GVs themselves and the treatment scheme are also found not to induce significant cytotoxicity, apoptosis, or membrane poration in treated cells. Altogether, this study demonstrates a simple and effective method to achieve enhanced and better-targeted neurostimulation with non-invasive low-intensity ultrasound.

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Focused ultrasound as an evolving therapy for Parkinson's disease

Cited by 8 publications

References 17 publications

Focusing in on the Future of Focused Ultrasound as a Translational Tool

Focusing in on the Future of Focused Ultrasound as a Translational Tool

Characterization of a Low-Profile, Flexible, and Acoustically Transparent Receive-Only MRI Coil Array for High Sensitivity MR-Guided Focused Ultrasound

Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators

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