“…4,5 The condition is incompletely understood and difficult to treat, with a lack of objective diagnostic tests and effective therapies. 6 In this phase I study, 7 the authors bring welcome attention to central lateral thalamotomy (CLT), also known as medial thalamotomy, which is gaining recognition by neurosurgeons and pain specialists as a potential treatment for refractory neuropathic pain. Although the lateral group of thalamic nuclei, such as the ventral posterior nucleus, receive significant direct inputs from the ascending spinothalamic and trigeminothalamic pathways, the medial group of thalamic nuclei are involved in regulating the cognitive and affective components of the experience of pain.…”