Focused ultrasound neuromodulation of cortical and subcortical brain structures using 1.9 MHz

Kamimura, Hermes A. S.; Wang, Shutao; Chen, Hong; Wang, Qi; Aurup, Christian; Acosta, Camilo J.; Carneiro, Adriana Munhoz; Konofagou, Elisa E.

doi:10.1118/1.4963208

Cited by 128 publications

(95 citation statements)

References 22 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, adding further weight to the idea that US stimulation acts directly on central motor neural circuits, several other studies have shown some level of stimulus localization with larger transducers and higher ultrasound frequencies, suggesting that smaller focal spots may result in direct neuromodulation effects with superior targeting specificity (Li et al, 2016, Kamimura et al, 2016. Further work is needed to determine more precisely which central motor neural circuits are being directly activated by ultrasound, perhaps using implanted EEG or cranial window whole brain measuring techniques.…”

Section: Discussionmentioning

confidence: 99%

“…Transcranial ultrasound stimulation in rodents has resulted in motor responses such as whole body twitches (Tufail et al, 2010, King et al, 2013, Ye et al, 2016. There also is evidence that ultrasound can be applied to modulate region-specific brain activity in rabbits and to induce lateralized motor responses in mice (Kamimura et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound neuromodulation

Mohammadjavadi

Xia

et al. 2018

Preprint

View full text Add to dashboard Cite

Recent studies in a variety of animal models including rodents, monkeys, and humans suggest that transcranial focused ultrasound (tFUS) has considerable promise for noninvasively modulating neural activity with the ability to target deep brain structures. However, concerns have been raised that motor responses evoked by tFUS may be due to indirect activation of the auditory pathway rather than direct activation of motor circuits. In this study, tFUS-induced electromyography (EMG) signals were recorded and analyzed in wild-type (WT) normal hearing mice and two strains of genetically deaf mice to examine the involvement of the peripheral auditory system in tFUS-stimulated motor responses. In addition, auditory brainstem responses (ABRs) were measured to elucidate the effect of the tFUS stimulus envelope on auditory and motor responses. We also varied the tFUS stimulation duration to measure its effect on motor response duration. We show, first, that the sharp edges in a tFUS rectangular envelope stimulus activate the peripheral afferent auditory pathway and, second, that smoothing these edges eliminates the auditory responses without affecting the motor responses in normal hearing WT mice. We further show that by eliminating peripheral auditory activity using two different strains of deaf knockout mice, motor responses are the same as in normal hearing WT mice. Finally, we demonstrate a high correlation between tFUS pulse duration and EMG response duration. These results support the concept that tFUS-evoked motor responses are not a result of stimulation of the peripheral auditory system.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound neuromodulation

Mohammadjavadi

Xia

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…13,17, 22,34 The current surge of interest in it as a noninvasive neurostimulation modality has been triggered by the following relatively recent findings: 1) FUS can elicit neuromodulatory effects in the CNS by using relatively short stimuli; 59 2) short stimuli of low intensity can trigger visible movements upon motor cortex stimulation in rodents; 25–27,35,38, 56,62 and 3) the method has been safely used in primates, including humans. 9,21,32–34,60 Given the enormous potential of this neurostimulation modality in causal brain mapping and treatments of deep brain circuits, work is currently under way to provide the information necessary for effective use.…”

Section: Transcranial Focused Ultrasoundmentioning

confidence: 99%

Neuromodulation with transcranial focused ultrasound

Kubanek

2018

Neurosurgical Focus

145

124

View full text Add to dashboard Cite

The understanding of brain function and the capacity to treat neurological and psychiatric disorders rest on the ability to intervene in neuronal activity in specific brain circuits. Current methods of neuromodulation incur a tradeoff between spatial focus and the level of invasiveness. Transcranial focused ultrasound (FUS) is emerging as a neuromodulation approach that combines noninvasiveness with focus that can be relatively sharp even in regions deep in the brain. This may enable studies of the causal role of specific brain regions in specific behaviors and behavioral disorders. In addition to causal brain mapping, the spatial focus of FUS opens new avenues for treatments of neurological and psychiatric conditions. This review introduces existing and emerging FUS applications in neuromodulation, discusses the mechanisms of FUS effects on cellular excitability, considers the effects of specific stimulation parameters, and lays out the directions for future work.

show abstract

“…superior colliculus, pretectal nucleus, and hippocampus etc. with 1.9 MHz focused ultrasound (PRF: 1 kHz, Duty cycle: 50%, lateral focus 1.0 mm, axial focus 8.5 mm), reproducibly inducing eyeball movement and pupillary dilation [38]. The improved spatial specificity produced by the increased FF was demonstrated to lead to consistent behavioral responses compared to lower FF scenarios [38].…”

Section: Tfus Directly Activates Local Brain Tissuementioning

confidence: 99%

On the neuromodulatory pathways of the in vivo brain by means of transcranial focused ultrasound

Niu

2018

Current Opinion in Biomedical Engineering

View full text Add to dashboard Cite

For last decade, low-intensity transcranial focused ultrasound (tFUS) has been rapidly developed for a myriad of successful applications in neuromodulation. tFUS possesses high spatial resolution, focality and depth penetration as a noninvasive neuromodulation tool. Despite the promise, confounding activation can be observed in rodents when stimulation parameters are not selected carefully. Here we summarize the existing classes of observations for ultrasound neuromodulation: ultrasound directly activates a localized area, or ultrasound indirectly activates auditory pathways, which further propagates to other cortical networks. We also present control in vivo animal studies, which suggest that underlying tFUS brain modulation is characterized by localized activation independent of auditory networks activations.

show abstract

Focused ultrasound neuromodulation of cortical and subcortical brain structures using 1.9 MHz

Cited by 128 publications

References 22 publications

Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound neuromodulation

Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound neuromodulation

Neuromodulation with transcranial focused ultrasound

On the neuromodulatory pathways of the in vivo brain by means of transcranial focused ultrasound

Contact Info

Product

Resources

About